Cellular senescence in aging and age-related disease: from mechanisms to therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-12

AUTHORS

Bennett G Childs, Matej Durik, Darren J Baker, Jan M van Deursen

ABSTRACT

Cellular senescence, a process that imposes permanent proliferative arrest on cells in response to various stressors, has emerged as a potentially important contributor to aging and age-related disease, and it is an attractive target for therapeutic exploitation. A wealth of information about senescence in cultured cells has been acquired over the past half century; however, senescence in living organisms is poorly understood, largely because of technical limitations relating to the identification and characterization of senescent cells in tissues and organs. Furthermore, newly recognized beneficial signaling functions of senescence suggest that indiscriminately targeting senescent cells or modulating their secretome for anti-aging therapy may have negative consequences. Here we discuss current progress and challenges in understanding the stressors that induce senescence in vivo, the cell types that are prone to senesce, and the autocrine and paracrine properties of senescent cells in the contexts of aging and age-related diseases as well as disease therapy. More... »

PAGES

1424-1435

References to SciGraph publications

  • 2014-02. Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure in NATURE MEDICINE
  • 2012-12. Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability in VASCULAR CELL
  • 2009-09. A crucial role for adipose tissue p53 in the regulation of insulin resistance in NATURE MEDICINE
  • 2005-08. BRAFE600-associated senescence-like cell cycle arrest of human naevi in NATURE
  • 2014-05. The role of senescent cells in ageing in NATURE
  • 2014-03. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice in NATURE MEDICINE
  • 2011-04. Are senescence and exhaustion intertwined or unrelated processes that compromise immunity? in NATURE REVIEWS IMMUNOLOGY
  • 2014-12. Smoking accelerates aging of the small airway epithelium in RESPIRATORY RESEARCH
  • 2011-11. Senescence surveillance of pre-malignant hepatocytes limits liver cancer development in NATURE
  • 2010-07. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing in NATURE CELL BIOLOGY
  • 2000-11. Insulin Resistance with Aging in SPORTS MEDICINE
  • 2006-11. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication in NATURE
  • 2004-07. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice in NATURE GENETICS
  • 2014-09. HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction in CELLULAR & MOLECULAR IMMUNOLOGY
  • 2005-01. Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice in DIABETOLOGIA
  • 2011-03. Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins in NATURE REVIEWS CANCER
  • 2011-11. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders in NATURE
  • 2008-07. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency in NATURE CELL BIOLOGY
  • 2013-12. Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study in RADIATION ONCOLOGY
  • 2007-02. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas in NATURE
  • 2008-01. A quantitative analysis of kinase inhibitor selectivity in NATURE BIOTECHNOLOGY
  • 2011-12. Cellular Senescence - its role in cancer and the response to ionizing radiation in GENOME INTEGRITY
  • 2001-09. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis in NATURE
  • 2014-02. Geriatric muscle stem cells switch reversible quiescence into senescence in NATURE
  • 2009-08. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion in NATURE CELL BIOLOGY
  • 2013-05. The ageing haematopoietic stem cell compartment in NATURE REVIEWS IMMUNOLOGY
  • 2014-12. Spartan deficiency causes genomic instability and progeroid phenotypes in NATURE COMMUNICATIONS
  • 2007-05. Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts in CELL DEATH & DIFFERENTIATION
  • 2013-09. Synthetic lethal metabolic targeting of cellular senescence in cancer therapy in NATURE
  • 2006-09. p16INK4a induces an age-dependent decline in islet regenerative potential in NATURE
  • 2006-11. Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence in NATURE CELL BIOLOGY
  • 1998-04. Essential role of mouse telomerase in highly proliferative organs in NATURE
  • 2009-12. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis in JOURNAL OF BIOMEDICAL SCIENCE
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    URI

    http://scigraph.springernature.com/pub.10.1038/nm.4000

    DOI

    http://dx.doi.org/10.1038/nm.4000

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017731876

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26646499


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