PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11

AUTHORS

Shiri Gur-Cohen, Tomer Itkin, Sagarika Chakrabarty, Claudine Graf, Orit Kollet, Aya Ludin, Karin Golan, Alexander Kalinkovich, Guy Ledergor, Eitan Wong, Elisabeth Niemeyer, Ziv Porat, Ayelet Erez, Irit Sagi, Charles T Esmon, Wolfram Ruf, Tsvee Lapidot

ABSTRACT

Retention of long-term repopulating hematopoietic stem cells (LT-HSCs) in the bone marrow is essential for hematopoiesis and for protection from myelotoxic injury. We report that signaling cascades that are traditionally viewed as coagulation related also control retention of endothelial protein C receptor-positive (EPCR(+)) LT-HSCs in the bone marrow and their recruitment to the blood via two pathways mediated by protease activated receptor 1 (PAR1). Thrombin-PAR1 signaling induces nitric oxide (NO) production, leading to EPCR shedding mediated by tumor necrosis factor-α-converting enzyme (TACE), enhanced CXCL12-CXCR4-induced motility and rapid stem and progenitor cell mobilization. Conversely, bone marrow blood vessels provide a microenvironment enriched with activated protein C (aPC) that retains EPCR(+) LT-HSCs by limiting NO generation, reducing Cdc42 activity and enhancing integrin VLA4 affinity and adhesion. Inhibition of NO production by aPC-EPCR-PAR1 signaling reduces progenitor cell egress from the bone marrow, increases retention of bone marrow NO(low) EPCR(+) LT-HSCs and protects mice from chemotherapy-induced hematological failure and death. Our study reveals new roles for PAR1 and EPCR in controlling NO production to balance maintenance and recruitment of bone marrow EPCR(+) LT-HSCs, with potential clinical relevance for stem cell transplantation. More... »

PAGES

1307-1317

References to SciGraph publications

  • 2014-11. Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells in NATURE MEDICINE
  • 2010-08. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche in NATURE
  • 2012-11. Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow in NATURE IMMUNOLOGY
  • 2014-11. Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion in NATURE MEDICINE
  • 2012-07. Pharmacological targeting of the thrombomodulin–activated protein C pathway mitigates radiation toxicity in NATURE MEDICINE
  • 2015-01. Identification of multipotent mammary stem cells by protein C receptor expression in NATURE
  • 2007-12. Regulation of nestin expression by thrombin and cell density in cultures of bone mesenchymal stem cells and radial glial cells in BMC NEUROSCIENCE
  • 2011-05. CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions in NATURE IMMUNOLOGY
  • 2002-07. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4 in NATURE IMMUNOLOGY
  • 2013-10. Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy in NATURE
  • 2013-12. Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking in NATURE COMMUNICATIONS
  • 2008-03. Haematopoietic stem cell release is regulated by circadian oscillations in NATURE
  • 2009-06. Biomechanical forces promote embryonic haematopoiesis in NATURE
  • 2011-08. Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells in LEUKEMIA
  • 2003-11. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.3960

    DOI

    http://dx.doi.org/10.1038/nm.3960

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026450884

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26457757


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