Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-06

AUTHORS

Ivan D Mascanfroni, Maisa C Takenaka, Ada Yeste, Bonny Patel, Yan Wu, Jessica E Kenison, Shafiuddin Siddiqui, Alexandre S Basso, Leo E Otterbein, Drew M Pardoll, Fan Pan, Avner Priel, Clary B Clish, Simon C Robson, Francisco J Quintana

ABSTRACT

Our understanding of the pathways that regulate lymphocyte metabolism, as well as the effects of metabolism and its products on the immune response, is still limited. We report that a metabolic program controlled by the transcription factors hypoxia inducible factor-1α (HIF1-α) and aryl hydrocarbon receptor (AHR) supports the differentiation of type 1 regulatory T cell (Tr1) cells. HIF1-α controls the early metabolic reprograming of Tr1 cells. At later time points, AHR promotes HIF1-α degradation and takes control of Tr1 cell metabolism. Extracellular ATP (eATP) and hypoxia, linked to inflammation, trigger AHR inactivation by HIF1-α and inhibit Tr1 cell differentiation. Conversely, CD39 promotes Tr1 cell differentiation by depleting eATP. CD39 also contributes to Tr1 suppressive activity by generating adenosine in cooperation with CD73 expressed by responder T cells and antigen-presenting cells. These results suggest that HIF1-α and AHR integrate immunological, metabolic and environmental signals to regulate the immune response. More... »

PAGES

638-646

References to SciGraph publications

  • 2013-06. Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells in NATURE MEDICINE
  • 2013-10. IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39 in NATURE IMMUNOLOGY
  • 2011-03. Immune cell regulation by autocrine purinergic signalling in NATURE REVIEWS IMMUNOLOGY
  • 2013-03-06. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1 in NATURE
  • 2013-03-06. Dynamic regulatory network controlling TH17 cell differentiation in NATURE
  • 1999-09. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation in NATURE MEDICINE
  • 2008-10-09. ATP drives lamina propria TH17 cell differentiation in NATURE
  • 2014-12. IL-21 induces IL-22 production in CD4+ T cells in NATURE COMMUNICATIONS
  • 2014-05. Nucleotide signalling during inflammation in NATURE
  • 2013-11. Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen in NATURE IMMUNOLOGY
  • 2010-09. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells in NATURE IMMUNOLOGY
  • 2013-06. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways in NATURE IMMUNOLOGY
  • 2010-09. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27 in NATURE IMMUNOLOGY
  • 2007-12. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 in NATURE IMMUNOLOGY
  • 2012-08. Aiolos promotes TH17 differentiation by directly silencing Il2 expression in NATURE IMMUNOLOGY
  • 2014-07. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses in NATURE REVIEWS IMMUNOLOGY
  • 2007-12. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells in NATURE IMMUNOLOGY
  • 2012-08. The P2X7 receptor is a key modulator of aerobic glycolysis in CELL DEATH & DISEASE
  • 2008-05. Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor in NATURE
  • 2007-12. A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells in NATURE IMMUNOLOGY
  • 2014. Tr1 Cells and the Counter-Regulation of Immunity: Natural Mechanisms and Therapeutic Applications in INTERLEUKIN-10 IN HEALTH AND DISEASE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.3868

    DOI

    http://dx.doi.org/10.1038/nm.3868

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019639985

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26005855


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antigens, CD", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Apyrase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Differentiation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hematopoiesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hypoxia-Inducible Factor 1, alpha Subunit", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Cellular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphocyte Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Aryl Hydrocarbon", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Regulatory", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mascanfroni", 
            "givenName": "Ivan D", 
            "id": "sg:person.01247101653.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247101653.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takenaka", 
            "givenName": "Maisa C", 
            "id": "sg:person.0711740126.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711740126.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yeste", 
            "givenName": "Ada", 
            "id": "sg:person.01307672423.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307672423.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Bonny", 
            "id": "sg:person.01150444436.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150444436.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wu", 
            "givenName": "Yan", 
            "id": "sg:person.0644370342.78", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644370342.78"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kenison", 
            "givenName": "Jessica E", 
            "id": "sg:person.0603751065.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603751065.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Siddiqui", 
            "givenName": "Shafiuddin", 
            "id": "sg:person.01100716613.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100716613.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Federal University of Sao Paulo", 
              "id": "https://www.grid.ac/institutes/grid.411249.b", 
              "name": [
                "Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Basso", 
            "givenName": "Alexandre S", 
            "id": "sg:person.01004621747.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004621747.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Otterbein", 
            "givenName": "Leo E", 
            "id": "sg:person.01175445403.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175445403.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pardoll", 
            "givenName": "Drew M", 
            "id": "sg:person.012740423777.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pan", 
            "givenName": "Fan", 
            "id": "sg:person.01355276034.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355276034.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alberta", 
              "id": "https://www.grid.ac/institutes/grid.17089.37", 
              "name": [
                "Department of Physics, University of Alberta, Edmonton, Alberta, Canada."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Priel", 
            "givenName": "Avner", 
            "id": "sg:person.01251736123.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251736123.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Massachusetts Institute of Technology", 
              "id": "https://www.grid.ac/institutes/grid.116068.8", 
              "name": [
                "Center for Proteomics, The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Clish", 
            "givenName": "Clary B", 
            "id": "sg:person.0764632420.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Division of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Robson", 
            "givenName": "Simon C", 
            "id": "sg:person.01011404226.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011404226.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Quintana", 
            "givenName": "Francisco J", 
            "id": "sg:person.0605704661.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605704661.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1126/science.1242454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003550892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra1205750", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004670183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.25989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004874855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2695", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005433890", 
              "https://doi.org/10.1038/ni.2695"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2607", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006314041", 
              "https://doi.org/10.1038/ni.2607"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.09.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008471213"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0105-2896.2006.00420.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008898909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1593/neo.101332", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009353050"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009732439", 
              "https://doi.org/10.1038/ni.2363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2012.105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010352533", 
              "https://doi.org/10.1038/cddis.2012.105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20062512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011849396"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pathol-012513-104720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013524544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pathol-012513-104720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013524544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-020711-075024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013745238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/12447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013810589", 
              "https://doi.org/10.1038/12447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms4753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014483618", 
              "https://doi.org/10.1038/ncomms4753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016530300", 
              "https://doi.org/10.1038/nri2938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/pr.113.007823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016794656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2007-06-096297", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018199948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra0910283", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018560894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1537", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019516627", 
              "https://doi.org/10.1038/ni1537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2010.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022793482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06880", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025127308", 
              "https://doi.org/10.1038/nature06880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri3701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025161314", 
              "https://doi.org/10.1038/nri3701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/embj.201386666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025426781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0900568", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028393909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029795137", 
              "https://doi.org/10.1038/ni.1915"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.01.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030045854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031832608", 
              "https://doi.org/10.1038/ni1541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0711175105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032267870"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2714", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034328134", 
              "https://doi.org/10.1038/ni.2714"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2011.09.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035134125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1912", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035443919", 
              "https://doi.org/10.1038/ni.1912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032713-120236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037205228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039390173", 
              "https://doi.org/10.1038/nature07240"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040134526", 
              "https://doi.org/10.1038/ni1540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.07.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040433624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2011.07.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040433624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1108856108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040892259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-immunol-032712-095956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042812136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.05.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043332744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.05.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044714130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11981", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044744930", 
              "https://doi.org/10.1038/nature11981"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0802978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044828684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-662-43492-5_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045380288", 
              "https://doi.org/10.1007/978-3-662-43492-5_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045636899", 
              "https://doi.org/10.1038/nature13085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0901233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047471901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20110278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047850300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050969377", 
              "https://doi.org/10.1038/nature11984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.09.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051015260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3179", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053642413", 
              "https://doi.org/10.1038/nm.3179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.smim.2011.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053678319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1003613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053705985"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-06", 
        "datePublishedReg": "2015-06-01", 
        "description": "Our understanding of the pathways that regulate lymphocyte metabolism, as well as the effects of metabolism and its products on the immune response, is still limited. We report that a metabolic program controlled by the transcription factors hypoxia inducible factor-1\u03b1 (HIF1-\u03b1) and aryl hydrocarbon receptor (AHR) supports the differentiation of type 1 regulatory T cell (Tr1) cells. HIF1-\u03b1 controls the early metabolic reprograming of Tr1 cells. At later time points, AHR promotes HIF1-\u03b1 degradation and takes control of Tr1 cell metabolism. Extracellular ATP (eATP) and hypoxia, linked to inflammation, trigger AHR inactivation by HIF1-\u03b1 and inhibit Tr1 cell differentiation. Conversely, CD39 promotes Tr1 cell differentiation by depleting eATP. CD39 also contributes to Tr1 suppressive activity by generating adenosine in cooperation with CD73 expressed by responder T cells and antigen-presenting cells. These results suggest that HIF1-\u03b1 and AHR integrate immunological, metabolic and environmental signals to regulate the immune response. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm.3868", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2441425", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2421945", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2459584", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3535257", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2459264", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2605964", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5244876", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5503667", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "name": "Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-\u03b1", 
        "pagination": "638-646", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5d93119417b03c40c3506b6b717983b1d6d1c7e522d92240bf54811123f0d567"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26005855"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm.3868"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1019639985"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm.3868", 
          "https://app.dimensions.ai/details/publication/pub.1019639985"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nm.3868"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.3868'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.3868'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.3868'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.3868'


     

    This table displays all metadata directly associated to this object as RDF triples.

    446 TRIPLES      21 PREDICATES      95 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm.3868 schema:about N194c40b5560343eea2dcf77ba2f3c9e7
    2 N1e62bafa6aca43018c3cc73a71b7c23e
    3 N25ef5b9e4c2f4a859b7680b7a0b7f694
    4 N26d58e22bcae4e0d8851b7d335fe4290
    5 N36e01c5439a24afe8b4434ef885c0a24
    6 N372730ac92ff40e9bbae6cb79620790a
    7 N3deb77cfc3e04a1185214509da47e90c
    8 N6fc7647005fe41c994973867d54e4d9d
    9 N7fa3ba69fbf74b038f7951ed90306d75
    10 N8e8a7d557c1b4e97a8461697a8b43960
    11 Nb765c920b51a41c9bcb8395177ac3905
    12 Nd958ae31554a4de2b7481e053e1f87b4
    13 Nddbf6d2b663e49249a0421bce1d3cbb3
    14 Ne951c5d0cd124494886ab1238dfb1008
    15 Ne9987de2a9db485f870dd29ab8883686
    16 anzsrc-for:11
    17 anzsrc-for:1107
    18 schema:author N7f0f241035e8463b9c6a863a49807bd1
    19 schema:citation sg:pub.10.1007/978-3-662-43492-5_3
    20 sg:pub.10.1038/12447
    21 sg:pub.10.1038/cddis.2012.105
    22 sg:pub.10.1038/nature06880
    23 sg:pub.10.1038/nature07240
    24 sg:pub.10.1038/nature11981
    25 sg:pub.10.1038/nature11984
    26 sg:pub.10.1038/nature13085
    27 sg:pub.10.1038/ncomms4753
    28 sg:pub.10.1038/ni.1912
    29 sg:pub.10.1038/ni.1915
    30 sg:pub.10.1038/ni.2363
    31 sg:pub.10.1038/ni.2607
    32 sg:pub.10.1038/ni.2695
    33 sg:pub.10.1038/ni.2714
    34 sg:pub.10.1038/ni1537
    35 sg:pub.10.1038/ni1540
    36 sg:pub.10.1038/ni1541
    37 sg:pub.10.1038/nm.3179
    38 sg:pub.10.1038/nri2938
    39 sg:pub.10.1038/nri3701
    40 https://doi.org/10.1002/hep.25989
    41 https://doi.org/10.1016/j.cell.2011.07.033
    42 https://doi.org/10.1016/j.cell.2012.01.021
    43 https://doi.org/10.1016/j.cell.2012.09.016
    44 https://doi.org/10.1016/j.cell.2013.05.016
    45 https://doi.org/10.1016/j.immuni.2006.09.013
    46 https://doi.org/10.1016/j.immuni.2009.05.012
    47 https://doi.org/10.1016/j.immuni.2011.09.021
    48 https://doi.org/10.1016/j.smim.2011.08.003
    49 https://doi.org/10.1053/j.gastro.2010.05.007
    50 https://doi.org/10.1056/nejmra0910283
    51 https://doi.org/10.1056/nejmra1205750
    52 https://doi.org/10.1073/pnas.0711175105
    53 https://doi.org/10.1073/pnas.1108856108
    54 https://doi.org/10.1084/jem.20062512
    55 https://doi.org/10.1084/jem.20110278
    56 https://doi.org/10.1111/j.0105-2896.2006.00420.x
    57 https://doi.org/10.1124/pr.113.007823
    58 https://doi.org/10.1126/science.1242454
    59 https://doi.org/10.1146/annurev-immunol-020711-075024
    60 https://doi.org/10.1146/annurev-immunol-032712-095956
    61 https://doi.org/10.1146/annurev-immunol-032713-120236
    62 https://doi.org/10.1146/annurev-pathol-012513-104720
    63 https://doi.org/10.1182/blood-2007-06-096297
    64 https://doi.org/10.15252/embj.201386666
    65 https://doi.org/10.1593/neo.101332
    66 https://doi.org/10.4049/jimmunol.0802978
    67 https://doi.org/10.4049/jimmunol.0900568
    68 https://doi.org/10.4049/jimmunol.0901233
    69 https://doi.org/10.4049/jimmunol.1003613
    70 schema:datePublished 2015-06
    71 schema:datePublishedReg 2015-06-01
    72 schema:description Our understanding of the pathways that regulate lymphocyte metabolism, as well as the effects of metabolism and its products on the immune response, is still limited. We report that a metabolic program controlled by the transcription factors hypoxia inducible factor-1α (HIF1-α) and aryl hydrocarbon receptor (AHR) supports the differentiation of type 1 regulatory T cell (Tr1) cells. HIF1-α controls the early metabolic reprograming of Tr1 cells. At later time points, AHR promotes HIF1-α degradation and takes control of Tr1 cell metabolism. Extracellular ATP (eATP) and hypoxia, linked to inflammation, trigger AHR inactivation by HIF1-α and inhibit Tr1 cell differentiation. Conversely, CD39 promotes Tr1 cell differentiation by depleting eATP. CD39 also contributes to Tr1 suppressive activity by generating adenosine in cooperation with CD73 expressed by responder T cells and antigen-presenting cells. These results suggest that HIF1-α and AHR integrate immunological, metabolic and environmental signals to regulate the immune response.
    73 schema:genre research_article
    74 schema:inLanguage en
    75 schema:isAccessibleForFree true
    76 schema:isPartOf N30cacb89f53e46a09654916bf37100f2
    77 N3e44995816384386b9e17bc84f99b24b
    78 sg:journal.1113716
    79 schema:name Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α
    80 schema:pagination 638-646
    81 schema:productId N0dde3d278d2b4cdab87f83ccacc6e11c
    82 N31678f7711f146d7a2daf3ea7327ca85
    83 N6016906f0cef4501bd2815b6b906968c
    84 N6e6944ac4eb34228a1fe7fae88b5aae6
    85 Nf68753bc7c794bfda5a752fbe8ab311c
    86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019639985
    87 https://doi.org/10.1038/nm.3868
    88 schema:sdDatePublished 2019-04-10T22:19
    89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    90 schema:sdPublisher N2dd332cc47d34647bfd38e2b665108c7
    91 schema:url http://www.nature.com/articles/nm.3868
    92 sgo:license sg:explorer/license/
    93 sgo:sdDataset articles
    94 rdf:type schema:ScholarlyArticle
    95 N078cd5f16f5d464f9bd8e4225aa32b21 schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    96 rdf:type schema:Organization
    97 N0bbca12b5d554f76819acb8bef724e3b rdf:first sg:person.0605704661.30
    98 rdf:rest rdf:nil
    99 N0dde3d278d2b4cdab87f83ccacc6e11c schema:name nlm_unique_id
    100 schema:value 9502015
    101 rdf:type schema:PropertyValue
    102 N0e49447025404ef6b735253ced2ac93b rdf:first sg:person.0711740126.15
    103 rdf:rest Nf5baf50b12fa481ab10f23c2e55d77db
    104 N1409290802f14f8eb967ade1627e8684 rdf:first sg:person.012740423777.12
    105 rdf:rest Nf80786f8b19f4a1b9c8b04b7e1f53f1d
    106 N1451e8b280a1489cbc7a5f62425138d1 rdf:first sg:person.01150444436.18
    107 rdf:rest N25729148bd7d4593b2acc04985298077
    108 N194c40b5560343eea2dcf77ba2f3c9e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Mice
    110 rdf:type schema:DefinedTerm
    111 N1e62bafa6aca43018c3cc73a71b7c23e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Humans
    113 rdf:type schema:DefinedTerm
    114 N25729148bd7d4593b2acc04985298077 rdf:first sg:person.0644370342.78
    115 rdf:rest Nbde70b7ab4494cd79575110b672f35ae
    116 N25ef5b9e4c2f4a859b7680b7a0b7f694 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Female
    118 rdf:type schema:DefinedTerm
    119 N26575813665f445384287dc8df35fa38 rdf:first sg:person.01004621747.24
    120 rdf:rest Nf41a18c4a2bd42d5809d8315877bee0f
    121 N26d58e22bcae4e0d8851b7d335fe4290 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Adult
    123 rdf:type schema:DefinedTerm
    124 N2dd332cc47d34647bfd38e2b665108c7 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 N30cacb89f53e46a09654916bf37100f2 schema:volumeNumber 21
    127 rdf:type schema:PublicationVolume
    128 N31678f7711f146d7a2daf3ea7327ca85 schema:name pubmed_id
    129 schema:value 26005855
    130 rdf:type schema:PropertyValue
    131 N36e01c5439a24afe8b4434ef885c0a24 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Hypoxia-Inducible Factor 1, alpha Subunit
    133 rdf:type schema:DefinedTerm
    134 N372730ac92ff40e9bbae6cb79620790a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Receptors, Aryl Hydrocarbon
    136 rdf:type schema:DefinedTerm
    137 N3deb77cfc3e04a1185214509da47e90c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Immunity, Cellular
    139 rdf:type schema:DefinedTerm
    140 N3e44995816384386b9e17bc84f99b24b schema:issueNumber 6
    141 rdf:type schema:PublicationIssue
    142 N6016906f0cef4501bd2815b6b906968c schema:name dimensions_id
    143 schema:value pub.1019639985
    144 rdf:type schema:PropertyValue
    145 N6e6944ac4eb34228a1fe7fae88b5aae6 schema:name doi
    146 schema:value 10.1038/nm.3868
    147 rdf:type schema:PropertyValue
    148 N6fc7647005fe41c994973867d54e4d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Inflammation
    150 rdf:type schema:DefinedTerm
    151 N6ff9352376ed4ab2a0e4a0f47d39fc0c schema:name Division of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
    152 rdf:type schema:Organization
    153 N72b9c958d535476697ea4ca2f92640bb schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    154 rdf:type schema:Organization
    155 N7a63a166146644029ae335a3468dc866 schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    156 rdf:type schema:Organization
    157 N7bae4d1f4c8f45adbf81ac6d436144d7 schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    158 rdf:type schema:Organization
    159 N7f0f241035e8463b9c6a863a49807bd1 rdf:first sg:person.01247101653.47
    160 rdf:rest N0e49447025404ef6b735253ced2ac93b
    161 N7fa3ba69fbf74b038f7951ed90306d75 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Apyrase
    163 rdf:type schema:DefinedTerm
    164 N89446960ba344bc89135a6d063308a89 schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    165 rdf:type schema:Organization
    166 N8e8a7d557c1b4e97a8461697a8b43960 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Animals
    168 rdf:type schema:DefinedTerm
    169 N96135fed6b0941db8248bd1577a198a4 schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    170 rdf:type schema:Organization
    171 Naa0d470490fe4571b9d2d79d370d21e6 rdf:first sg:person.01011404226.36
    172 rdf:rest N0bbca12b5d554f76819acb8bef724e3b
    173 Nad88df7c05aa4fa7b059f1740e56988a schema:name Division of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
    174 rdf:type schema:Organization
    175 Nb765c920b51a41c9bcb8395177ac3905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Cell Differentiation
    177 rdf:type schema:DefinedTerm
    178 Nbde70b7ab4494cd79575110b672f35ae rdf:first sg:person.0603751065.64
    179 rdf:rest Nec8dded551a44ecf97626a52d452164b
    180 Ncd40376a4d3542be97feb04b53d03fdf rdf:first sg:person.0764632420.16
    181 rdf:rest Naa0d470490fe4571b9d2d79d370d21e6
    182 Nd749d171fffe407a92ad7c5a1f449b9b rdf:first sg:person.01251736123.31
    183 rdf:rest Ncd40376a4d3542be97feb04b53d03fdf
    184 Nd958ae31554a4de2b7481e053e1f87b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name T-Lymphocytes, Regulatory
    186 rdf:type schema:DefinedTerm
    187 Nddbf6d2b663e49249a0421bce1d3cbb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Antigens, CD
    189 rdf:type schema:DefinedTerm
    190 Ne476ae06294946af92c4a2750752bd95 schema:name Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    191 rdf:type schema:Organization
    192 Ne951c5d0cd124494886ab1238dfb1008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Lymphocyte Activation
    194 rdf:type schema:DefinedTerm
    195 Ne9987de2a9db485f870dd29ab8883686 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Hematopoiesis
    197 rdf:type schema:DefinedTerm
    198 Nec8dded551a44ecf97626a52d452164b rdf:first sg:person.01100716613.16
    199 rdf:rest N26575813665f445384287dc8df35fa38
    200 Ned251dae07b04d9db8bd56aa6d7824f3 schema:name Division of Gastroenterology, Hepatology and Transplantation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
    201 rdf:type schema:Organization
    202 Nf41a18c4a2bd42d5809d8315877bee0f rdf:first sg:person.01175445403.45
    203 rdf:rest N1409290802f14f8eb967ade1627e8684
    204 Nf5baf50b12fa481ab10f23c2e55d77db rdf:first sg:person.01307672423.51
    205 rdf:rest N1451e8b280a1489cbc7a5f62425138d1
    206 Nf68753bc7c794bfda5a752fbe8ab311c schema:name readcube_id
    207 schema:value 5d93119417b03c40c3506b6b717983b1d6d1c7e522d92240bf54811123f0d567
    208 rdf:type schema:PropertyValue
    209 Nf80786f8b19f4a1b9c8b04b7e1f53f1d rdf:first sg:person.01355276034.35
    210 rdf:rest Nd749d171fffe407a92ad7c5a1f449b9b
    211 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    212 schema:name Medical and Health Sciences
    213 rdf:type schema:DefinedTerm
    214 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Immunology
    216 rdf:type schema:DefinedTerm
    217 sg:grant.2421945 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2441425 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2459264 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.2459584 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    224 rdf:type schema:MonetaryGrant
    225 sg:grant.2605964 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    226 rdf:type schema:MonetaryGrant
    227 sg:grant.3535257 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    228 rdf:type schema:MonetaryGrant
    229 sg:grant.5244876 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    230 rdf:type schema:MonetaryGrant
    231 sg:grant.5503667 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3868
    232 rdf:type schema:MonetaryGrant
    233 sg:journal.1113716 schema:issn 1078-8956
    234 1546-170X
    235 schema:name Nature Medicine
    236 rdf:type schema:Periodical
    237 sg:person.01004621747.24 schema:affiliation https://www.grid.ac/institutes/grid.411249.b
    238 schema:familyName Basso
    239 schema:givenName Alexandre S
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004621747.24
    241 rdf:type schema:Person
    242 sg:person.01011404226.36 schema:affiliation N6ff9352376ed4ab2a0e4a0f47d39fc0c
    243 schema:familyName Robson
    244 schema:givenName Simon C
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011404226.36
    246 rdf:type schema:Person
    247 sg:person.01100716613.16 schema:affiliation N7a63a166146644029ae335a3468dc866
    248 schema:familyName Siddiqui
    249 schema:givenName Shafiuddin
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100716613.16
    251 rdf:type schema:Person
    252 sg:person.01150444436.18 schema:affiliation N89446960ba344bc89135a6d063308a89
    253 schema:familyName Patel
    254 schema:givenName Bonny
    255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150444436.18
    256 rdf:type schema:Person
    257 sg:person.01175445403.45 schema:affiliation Ned251dae07b04d9db8bd56aa6d7824f3
    258 schema:familyName Otterbein
    259 schema:givenName Leo E
    260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01175445403.45
    261 rdf:type schema:Person
    262 sg:person.01247101653.47 schema:affiliation N96135fed6b0941db8248bd1577a198a4
    263 schema:familyName Mascanfroni
    264 schema:givenName Ivan D
    265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247101653.47
    266 rdf:type schema:Person
    267 sg:person.01251736123.31 schema:affiliation https://www.grid.ac/institutes/grid.17089.37
    268 schema:familyName Priel
    269 schema:givenName Avner
    270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251736123.31
    271 rdf:type schema:Person
    272 sg:person.012740423777.12 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    273 schema:familyName Pardoll
    274 schema:givenName Drew M
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12
    276 rdf:type schema:Person
    277 sg:person.01307672423.51 schema:affiliation N72b9c958d535476697ea4ca2f92640bb
    278 schema:familyName Yeste
    279 schema:givenName Ada
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307672423.51
    281 rdf:type schema:Person
    282 sg:person.01355276034.35 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    283 schema:familyName Pan
    284 schema:givenName Fan
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355276034.35
    286 rdf:type schema:Person
    287 sg:person.0603751065.64 schema:affiliation Ne476ae06294946af92c4a2750752bd95
    288 schema:familyName Kenison
    289 schema:givenName Jessica E
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603751065.64
    291 rdf:type schema:Person
    292 sg:person.0605704661.30 schema:affiliation N7bae4d1f4c8f45adbf81ac6d436144d7
    293 schema:familyName Quintana
    294 schema:givenName Francisco J
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0605704661.30
    296 rdf:type schema:Person
    297 sg:person.0644370342.78 schema:affiliation Nad88df7c05aa4fa7b059f1740e56988a
    298 schema:familyName Wu
    299 schema:givenName Yan
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0644370342.78
    301 rdf:type schema:Person
    302 sg:person.0711740126.15 schema:affiliation N078cd5f16f5d464f9bd8e4225aa32b21
    303 schema:familyName Takenaka
    304 schema:givenName Maisa C
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711740126.15
    306 rdf:type schema:Person
    307 sg:person.0764632420.16 schema:affiliation https://www.grid.ac/institutes/grid.116068.8
    308 schema:familyName Clish
    309 schema:givenName Clary B
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764632420.16
    311 rdf:type schema:Person
    312 sg:pub.10.1007/978-3-662-43492-5_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045380288
    313 https://doi.org/10.1007/978-3-662-43492-5_3
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/12447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013810589
    316 https://doi.org/10.1038/12447
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/cddis.2012.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010352533
    319 https://doi.org/10.1038/cddis.2012.105
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/nature06880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025127308
    322 https://doi.org/10.1038/nature06880
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/nature07240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039390173
    325 https://doi.org/10.1038/nature07240
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature11981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044744930
    328 https://doi.org/10.1038/nature11981
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nature11984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050969377
    331 https://doi.org/10.1038/nature11984
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature13085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045636899
    334 https://doi.org/10.1038/nature13085
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/ncomms4753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014483618
    337 https://doi.org/10.1038/ncomms4753
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/ni.1912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035443919
    340 https://doi.org/10.1038/ni.1912
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/ni.1915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029795137
    343 https://doi.org/10.1038/ni.1915
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/ni.2363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009732439
    346 https://doi.org/10.1038/ni.2363
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/ni.2607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006314041
    349 https://doi.org/10.1038/ni.2607
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/ni.2695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005433890
    352 https://doi.org/10.1038/ni.2695
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/ni.2714 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034328134
    355 https://doi.org/10.1038/ni.2714
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/ni1537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019516627
    358 https://doi.org/10.1038/ni1537
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/ni1540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040134526
    361 https://doi.org/10.1038/ni1540
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/ni1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031832608
    364 https://doi.org/10.1038/ni1541
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nm.3179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053642413
    367 https://doi.org/10.1038/nm.3179
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nri2938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016530300
    370 https://doi.org/10.1038/nri2938
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nri3701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025161314
    373 https://doi.org/10.1038/nri3701
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1002/hep.25989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004874855
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1016/j.cell.2011.07.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040433624
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1016/j.cell.2012.01.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030045854
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1016/j.cell.2012.09.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051015260
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1016/j.cell.2013.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043332744
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1016/j.immuni.2006.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008471213
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1016/j.immuni.2009.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044714130
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1016/j.immuni.2011.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035134125
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1016/j.smim.2011.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053678319
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1053/j.gastro.2010.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022793482
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1056/nejmra0910283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018560894
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1056/nejmra1205750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004670183
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1073/pnas.0711175105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032267870
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1073/pnas.1108856108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040892259
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1084/jem.20062512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011849396
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1084/jem.20110278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047850300
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1111/j.0105-2896.2006.00420.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008898909
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1124/pr.113.007823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016794656
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1126/science.1242454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003550892
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1146/annurev-immunol-020711-075024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013745238
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1146/annurev-immunol-032712-095956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042812136
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1146/annurev-immunol-032713-120236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037205228
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1146/annurev-pathol-012513-104720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013524544
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1182/blood-2007-06-096297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018199948
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.15252/embj.201386666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025426781
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1593/neo.101332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009353050
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.4049/jimmunol.0802978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044828684
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.4049/jimmunol.0900568 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028393909
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.4049/jimmunol.0901233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047471901
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.4049/jimmunol.1003613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705985
    434 rdf:type schema:CreativeWork
    435 https://www.grid.ac/institutes/grid.116068.8 schema:alternateName Massachusetts Institute of Technology
    436 schema:name Center for Proteomics, The Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, Massachusetts, USA.
    437 rdf:type schema:Organization
    438 https://www.grid.ac/institutes/grid.17089.37 schema:alternateName University of Alberta
    439 schema:name Department of Physics, University of Alberta, Edmonton, Alberta, Canada.
    440 rdf:type schema:Organization
    441 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    442 schema:name Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    443 rdf:type schema:Organization
    444 https://www.grid.ac/institutes/grid.411249.b schema:alternateName Federal University of Sao Paulo
    445 schema:name Department of Microbiology, Immunology and Parasitology, Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
    446 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...