The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-04-27

AUTHORS

Lucas Vicuña, David E Strochlic, Alban Latremoliere, Kiran Kumar Bali, Manuela Simonetti, Dewi Husainie, Sandra Prokosch, Priscilla Riva, Robert S Griffin, Christian Njoo, Stefanie Gehrig, Marcus A Mall, Bernd Arnold, Marshall Devor, Clifford J Woolf, Stephen D Liberles, Michael Costigan, Rohini Kuner

ABSTRACT

Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured groups, which can be difficult to validate, particularly with respect to the specificity of pain modulation. To circumvent this, we used two outbred lines of rats, which are genetically similar except for being genetically segregated as a result of selective breeding for differences in neuropathic pain hypersensitivity. SerpinA3N, a serine protease inhibitor, was upregulated in the dorsal root ganglia (DRG) after nerve injury, which was further validated for its mouse homolog. Mice lacking SerpinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exogenous delivery of SerpinA3N attenuated mechanical allodynia in WT mice. T lymphocytes infiltrate the DRG after nerve injury and release leukocyte elastase (LE), which was inhibited by SerpinA3N derived from DRG neurons. Genetic loss of LE or exogenous application of a LE inhibitor (Sivelastat) in WT mice attenuated neuropathic mechanical allodynia. Overall, we reveal a novel and clinically relevant role for a member of the serpin superfamily and a leukocyte elastase and crosstalk between neurons and T cells in the modulation of neuropathic pain. More... »

PAGES

518-523

References to SciGraph publications

  • 2010-01-22. Human Neutrophil Elastase-Mediated Cleavage Sites of MMP-9 and TIMP-1: Implications to Cystic Fibrosis Proteolytic Dysfunction in MOLECULAR MEDICINE
  • 2006-07. Neutrophil serine proteases: specific regulators of inflammation in NATURE REVIEWS IMMUNOLOGY
  • 2013-11-24. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses in NATURE IMMUNOLOGY
  • 2005-09-04. Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity in NATURE IMMUNOLOGY
  • 2006-10-22. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence in NATURE MEDICINE
  • 2012-10-06. Pain in experimental autoimmune encephalitis: a comparative study between different mouse models in JOURNAL OF NEUROINFLAMMATION
  • 2010-05-30. BASOPHILS AND THE T HELPER 2 ENVIRONMENT CAN PROMOTE THE DEVELOPMENT OF LUPUS NEPHRITIS in NATURE MEDICINE
  • 1998-05. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis in NATURE MEDICINE
  • 2002-10-25. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. in BMC NEUROSCIENCE
  • 2008-02-10. Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain in NATURE MEDICINE
  • 2013-07-23. hESC-derived Olig2+ progenitors generate a subtype of astroglia with protective effects against ischaemic brain injury in NATURE COMMUNICATIONS
  • 2001-05. A candidate taste receptor gene near a sweet taste locus in NATURE NEUROSCIENCE
  • 2007-10-26. The neuropathic pain triad: neurons, immune cells and glia in NATURE NEUROSCIENCE
  • 2012-03-25. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity in NATURE MEDICINE
  • 2004-09-15. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • Journal

    TITLE

    Nature Medicine

    ISSUE

    5

    VOLUME

    21

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.3852

    DOI

    http://dx.doi.org/10.1038/nm.3852

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1008739695

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25915831


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acute-Phase Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Separation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dependovirus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ganglia, Spinal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hyperalgesia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Situ Hybridization", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukocyte Elastase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Transgenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neuralgia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oligonucleotide Array Sequence Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymerase Chain Reaction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Serpins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Up-Regulation", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vicu\u00f1a", 
            "givenName": "Lucas", 
            "id": "sg:person.0577073371.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577073371.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Strochlic", 
            "givenName": "David E", 
            "id": "sg:person.0630721070.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630721070.97"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.", 
              "id": "http://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Latremoliere", 
            "givenName": "Alban", 
            "id": "sg:person.01071205714.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071205714.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bali", 
            "givenName": "Kiran Kumar", 
            "id": "sg:person.01201731244.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201731244.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Simonetti", 
            "givenName": "Manuela", 
            "id": "sg:person.0677425671.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677425671.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Husainie", 
            "givenName": "Dewi", 
            "id": "sg:person.01075663571.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075663571.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Prokosch", 
            "givenName": "Sandra", 
            "id": "sg:person.01365743302.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365743302.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.", 
              "id": "http://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riva", 
            "givenName": "Priscilla", 
            "id": "sg:person.01212112171.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212112171.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA.", 
              "id": "http://www.grid.ac/institutes/grid.239915.5", 
              "name": [
                "Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Griffin", 
            "givenName": "Robert S", 
            "id": "sg:person.0721522537.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721522537.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Njoo", 
            "givenName": "Christian", 
            "id": "sg:person.0751254244.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751254244.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gehrig", 
            "givenName": "Stefanie", 
            "id": "sg:person.01170077066.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170077066.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mall", 
            "givenName": "Marcus A", 
            "id": "sg:person.01250456513.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250456513.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arnold", 
            "givenName": "Bernd", 
            "id": "sg:person.01347043014.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347043014.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.", 
              "id": "http://www.grid.ac/institutes/grid.9619.7", 
              "name": [
                "Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Devor", 
            "givenName": "Marshall", 
            "id": "sg:person.01321023611.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321023611.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.", 
              "id": "http://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Woolf", 
            "givenName": "Clifford J", 
            "id": "sg:person.0740501552.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740501552.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.", 
              "id": "http://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liberles", 
            "givenName": "Stephen D", 
            "id": "sg:person.01164225504.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164225504.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA.", 
              "id": "http://www.grid.ac/institutes/grid.2515.3", 
              "name": [
                "1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Costigan", 
            "givenName": "Michael", 
            "id": "sg:person.01041441555.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041441555.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.", 
              "id": "http://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Pharmacology Institute, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuner", 
            "givenName": "Rohini", 
            "id": "sg:person.0607245213.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607245213.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm.2710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006175749", 
              "https://doi.org/10.1038/nm.2710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.2766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051835983", 
              "https://doi.org/10.1038/ni.2766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2119/molmed.2009.00109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068965221", 
              "https://doi.org/10.2119/molmed.2009.00109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015312883", 
              "https://doi.org/10.1038/nm1490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/gb-2004-5-10-r80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018457673", 
              "https://doi.org/10.1186/gb-2004-5-10-r80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000974597", 
              "https://doi.org/10.1038/nm1723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2202-3-16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007072033", 
              "https://doi.org/10.1186/1471-2202-3-16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012728298", 
              "https://doi.org/10.1038/nm.2159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006465182", 
              "https://doi.org/10.1038/nn1992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm0598-615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048689553", 
              "https://doi.org/10.1038/nm0598-615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1841", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008265635", 
              "https://doi.org/10.1038/nri1841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-9-233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003661949", 
              "https://doi.org/10.1186/1742-2094-9-233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032419209", 
              "https://doi.org/10.1038/ni1244"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms3196", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048227622", 
              "https://doi.org/10.1038/ncomms3196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/87440", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044718933", 
              "https://doi.org/10.1038/87440"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2015-04-27", 
        "datePublishedReg": "2015-04-27", 
        "description": "Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured groups, which can be difficult to validate, particularly with respect to the specificity of pain modulation. To circumvent this, we used two outbred lines of rats, which are genetically similar except for being genetically segregated as a result of selective breeding for differences in neuropathic pain hypersensitivity. SerpinA3N, a serine protease inhibitor, was upregulated in the dorsal root ganglia (DRG) after nerve injury, which was further validated for its mouse homolog. Mice lacking SerpinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exogenous delivery of SerpinA3N attenuated mechanical allodynia in WT mice. T lymphocytes infiltrate the DRG after nerve injury and release leukocyte elastase (LE), which was inhibited by SerpinA3N derived from DRG neurons. Genetic loss of LE or exogenous application of a LE inhibitor (Sivelastat) in WT mice attenuated neuropathic mechanical allodynia. Overall, we reveal a novel and clinically relevant role for a member of the serpin superfamily and a leukocyte elastase and crosstalk between neurons and T cells in the modulation of neuropathic pain. ", 
        "genre": "article", 
        "id": "sg:pub.10.1038/nm.3852", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.3791931", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2563045", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2558976", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2636181", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2578969", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2491499", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "21"
          }
        ], 
        "keywords": [
          "dorsal root ganglia", 
          "neuropathic mechanical allodynia", 
          "mechanical allodynia", 
          "neuropathic pain", 
          "nerve injury", 
          "WT mice", 
          "leukocyte elastase", 
          "nerve-injured group", 
          "neuropathic pain hypersensitivity", 
          "serine protease inhibitor", 
          "intractable clinical problem", 
          "wild-type mice", 
          "protease inhibitors", 
          "pain hypersensitivity", 
          "pain modulation", 
          "pain therapy", 
          "DRG neurons", 
          "root ganglia", 
          "clinical problem", 
          "allodynia", 
          "pain", 
          "study design", 
          "novel target", 
          "mice", 
          "recent gene expression", 
          "injury", 
          "elastase", 
          "neurons", 
          "inhibitors", 
          "unclear results", 
          "exogenous delivery", 
          "genetic loss", 
          "differential expression", 
          "gene expression", 
          "ganglia", 
          "pathophysiology", 
          "sham", 
          "relevant role", 
          "therapy", 
          "lymphocytes", 
          "expression", 
          "rats", 
          "hypersensitivity", 
          "Serpina3n", 
          "modulation", 
          "mouse homolog", 
          "classical study designs", 
          "delivery", 
          "cells", 
          "group", 
          "specificity", 
          "exogenous application", 
          "target", 
          "differences", 
          "serpins", 
          "study", 
          "role", 
          "genes", 
          "outbred lines", 
          "loss", 
          "crosstalk", 
          "results", 
          "identification", 
          "members", 
          "lines", 
          "selective breeding", 
          "homolog", 
          "respect", 
          "novel", 
          "hundreds", 
          "design", 
          "problem", 
          "applications", 
          "breeding", 
          "LE inhibitor", 
          "cell-derived leukocyte elastase"
        ], 
        "name": "The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase", 
        "pagination": "518-523", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1008739695"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm.3852"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25915831"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm.3852", 
          "https://app.dimensions.ai/details/publication/pub.1008739695"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_652.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/nm.3852"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.3852'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.3852'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.3852'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.3852'


     

    This table displays all metadata directly associated to this object as RDF triples.

    443 TRIPLES      22 PREDICATES      140 URIs      117 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm.3852 schema:about N0b88d4f2873c4a28a18d5f9391bd278f
    2 N0fef41aec9db43a48f4afd21ded16d9e
    3 N26d6e81cd7714754a37ab987bea1eb35
    4 N26ded685e51c4b5ab85293a63e89d7cf
    5 N2c11dfda8f454c00b2e2b8bc732969e0
    6 N2c53c8b7222f4553b473151dab9a6293
    7 N2d0946354f444b8bb9fb9ad97e946162
    8 N33e9178fcd8843de9017bc30bd0671fc
    9 N46d3f6532b10458388b4d3d369141d23
    10 N4d4b8e65b8844ea69704eb0d12a96154
    11 N60202830cfa7497cb35907db0b631f0e
    12 N7bb38e2338a34209aa68339afeecbc09
    13 N7d8ea405b58a4438aa31a7625818f10c
    14 N7e1d5cd2f3f04f2e8ef960a1c58000eb
    15 N90a5ff0d8deb440bb40206e6fa6011fc
    16 Na16c2e3711fd43978fc7cf5f1d9ea8ec
    17 Nb14c279850494184a0941d4c4c17987a
    18 Nc05aef4441524f4ca329464c4d4d3f04
    19 Nd8019d857c45421589c30102b32f6c6f
    20 Ndb4114a5e0d44ccf9126d89f6006d517
    21 Ne0148fb26b2f41b9b014714a52e5777d
    22 Ne964d04115fb48ea82ddf02a4f896c07
    23 Nf780d02097844089bfd612daf54ce4f5
    24 anzsrc-for:11
    25 anzsrc-for:1109
    26 schema:author N58a0430ccacb46019e7638797bdd9ed8
    27 schema:citation sg:pub.10.1038/87440
    28 sg:pub.10.1038/ncomms3196
    29 sg:pub.10.1038/ni.2766
    30 sg:pub.10.1038/ni1244
    31 sg:pub.10.1038/nm.2159
    32 sg:pub.10.1038/nm.2710
    33 sg:pub.10.1038/nm0598-615
    34 sg:pub.10.1038/nm1490
    35 sg:pub.10.1038/nm1723
    36 sg:pub.10.1038/nn1992
    37 sg:pub.10.1038/nri1841
    38 sg:pub.10.1186/1471-2202-3-16
    39 sg:pub.10.1186/1742-2094-9-233
    40 sg:pub.10.1186/gb-2004-5-10-r80
    41 sg:pub.10.2119/molmed.2009.00109
    42 schema:datePublished 2015-04-27
    43 schema:datePublishedReg 2015-04-27
    44 schema:description Neuropathic pain is a major, intractable clinical problem and its pathophysiology is not well understood. Although recent gene expression profiling studies have enabled the identification of novel targets for pain therapy, classical study designs provide unclear results owing to the differential expression of hundreds of genes across sham and nerve-injured groups, which can be difficult to validate, particularly with respect to the specificity of pain modulation. To circumvent this, we used two outbred lines of rats, which are genetically similar except for being genetically segregated as a result of selective breeding for differences in neuropathic pain hypersensitivity. SerpinA3N, a serine protease inhibitor, was upregulated in the dorsal root ganglia (DRG) after nerve injury, which was further validated for its mouse homolog. Mice lacking SerpinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exogenous delivery of SerpinA3N attenuated mechanical allodynia in WT mice. T lymphocytes infiltrate the DRG after nerve injury and release leukocyte elastase (LE), which was inhibited by SerpinA3N derived from DRG neurons. Genetic loss of LE or exogenous application of a LE inhibitor (Sivelastat) in WT mice attenuated neuropathic mechanical allodynia. Overall, we reveal a novel and clinically relevant role for a member of the serpin superfamily and a leukocyte elastase and crosstalk between neurons and T cells in the modulation of neuropathic pain.
    45 schema:genre article
    46 schema:inLanguage en
    47 schema:isAccessibleForFree true
    48 schema:isPartOf N094cd5ebf26a437093f6117ba4d64938
    49 N22fe8ce076874fb8aa4d5a24986b497f
    50 sg:journal.1113716
    51 schema:keywords DRG neurons
    52 LE inhibitor
    53 Serpina3n
    54 WT mice
    55 allodynia
    56 applications
    57 breeding
    58 cell-derived leukocyte elastase
    59 cells
    60 classical study designs
    61 clinical problem
    62 crosstalk
    63 delivery
    64 design
    65 differences
    66 differential expression
    67 dorsal root ganglia
    68 elastase
    69 exogenous application
    70 exogenous delivery
    71 expression
    72 ganglia
    73 gene expression
    74 genes
    75 genetic loss
    76 group
    77 homolog
    78 hundreds
    79 hypersensitivity
    80 identification
    81 inhibitors
    82 injury
    83 intractable clinical problem
    84 leukocyte elastase
    85 lines
    86 loss
    87 lymphocytes
    88 mechanical allodynia
    89 members
    90 mice
    91 modulation
    92 mouse homolog
    93 nerve injury
    94 nerve-injured group
    95 neurons
    96 neuropathic mechanical allodynia
    97 neuropathic pain
    98 neuropathic pain hypersensitivity
    99 novel
    100 novel target
    101 outbred lines
    102 pain
    103 pain hypersensitivity
    104 pain modulation
    105 pain therapy
    106 pathophysiology
    107 problem
    108 protease inhibitors
    109 rats
    110 recent gene expression
    111 relevant role
    112 respect
    113 results
    114 role
    115 root ganglia
    116 selective breeding
    117 serine protease inhibitor
    118 serpins
    119 sham
    120 specificity
    121 study
    122 study design
    123 target
    124 therapy
    125 unclear results
    126 wild-type mice
    127 schema:name The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
    128 schema:pagination 518-523
    129 schema:productId N0a9af2d33a474c03a44ed66ededd8664
    130 N563b154f5e2646cf85272fa7fc6f039e
    131 N5975a82d73b2469f87747f11af91fcf9
    132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008739695
    133 https://doi.org/10.1038/nm.3852
    134 schema:sdDatePublished 2022-01-01T18:35
    135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    136 schema:sdPublisher N9c59c253473a4f53a6b8400d5e4996bb
    137 schema:url https://doi.org/10.1038/nm.3852
    138 sgo:license sg:explorer/license/
    139 sgo:sdDataset articles
    140 rdf:type schema:ScholarlyArticle
    141 N094cd5ebf26a437093f6117ba4d64938 schema:issueNumber 5
    142 rdf:type schema:PublicationIssue
    143 N0a9af2d33a474c03a44ed66ededd8664 schema:name doi
    144 schema:value 10.1038/nm.3852
    145 rdf:type schema:PropertyValue
    146 N0b88d4f2873c4a28a18d5f9391bd278f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Ganglia, Spinal
    148 rdf:type schema:DefinedTerm
    149 N0fef41aec9db43a48f4afd21ded16d9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Oligonucleotide Array Sequence Analysis
    151 rdf:type schema:DefinedTerm
    152 N22fe8ce076874fb8aa4d5a24986b497f schema:volumeNumber 21
    153 rdf:type schema:PublicationVolume
    154 N26d6e81cd7714754a37ab987bea1eb35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Neuralgia
    156 rdf:type schema:DefinedTerm
    157 N26ded685e51c4b5ab85293a63e89d7cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Enzyme Inhibitors
    159 rdf:type schema:DefinedTerm
    160 N2c11dfda8f454c00b2e2b8bc732969e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    161 schema:name Rats
    162 rdf:type schema:DefinedTerm
    163 N2c53c8b7222f4553b473151dab9a6293 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Cell Separation
    165 rdf:type schema:DefinedTerm
    166 N2cb3d0cd789d4cd3b8a360292d487abb rdf:first sg:person.01041441555.34
    167 rdf:rest N39f8e02c185d4a9f953c9cedca30d2ca
    168 N2d0946354f444b8bb9fb9ad97e946162 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Up-Regulation
    170 rdf:type schema:DefinedTerm
    171 N33e9178fcd8843de9017bc30bd0671fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Serpins
    173 rdf:type schema:DefinedTerm
    174 N36d28624493a4e80bdf4e45c84112daa rdf:first sg:person.0751254244.47
    175 rdf:rest Nc5bc69cdf38c479f96f5b5409b9d9c10
    176 N36db1f8c804f4d33910d86e95798846c rdf:first sg:person.01347043014.88
    177 rdf:rest Nb2565c12eb384741a92a5e0e151d21d2
    178 N39f8e02c185d4a9f953c9cedca30d2ca rdf:first sg:person.0607245213.51
    179 rdf:rest rdf:nil
    180 N46d3f6532b10458388b4d3d369141d23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Neurons
    182 rdf:type schema:DefinedTerm
    183 N4d4b8e65b8844ea69704eb0d12a96154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Leukocyte Elastase
    185 rdf:type schema:DefinedTerm
    186 N563b154f5e2646cf85272fa7fc6f039e schema:name pubmed_id
    187 schema:value 25915831
    188 rdf:type schema:PropertyValue
    189 N58a0430ccacb46019e7638797bdd9ed8 rdf:first sg:person.0577073371.77
    190 rdf:rest N5f624737544f4236b325647f6fe586b8
    191 N5975a82d73b2469f87747f11af91fcf9 schema:name dimensions_id
    192 schema:value pub.1008739695
    193 rdf:type schema:PropertyValue
    194 N5a6d86d4144947a5a11162508bf8d2ad rdf:first sg:person.01212112171.28
    195 rdf:rest N6adc71d65b7e4f7b9c9730e6b49b337a
    196 N5f624737544f4236b325647f6fe586b8 rdf:first sg:person.0630721070.97
    197 rdf:rest Nb8ba90881a6b4b74883e7cf6bac7a890
    198 N60202830cfa7497cb35907db0b631f0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Pain
    200 rdf:type schema:DefinedTerm
    201 N6656764f62384887ad63ec536997322d rdf:first sg:person.01164225504.68
    202 rdf:rest N2cb3d0cd789d4cd3b8a360292d487abb
    203 N6adc71d65b7e4f7b9c9730e6b49b337a rdf:first sg:person.0721522537.86
    204 rdf:rest N36d28624493a4e80bdf4e45c84112daa
    205 N7bb38e2338a34209aa68339afeecbc09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name Female
    207 rdf:type schema:DefinedTerm
    208 N7d8ea405b58a4438aa31a7625818f10c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name T-Lymphocytes
    210 rdf:type schema:DefinedTerm
    211 N7e1d5cd2f3f04f2e8ef960a1c58000eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name Mice, Transgenic
    213 rdf:type schema:DefinedTerm
    214 N88d0a93fdcf2491a9b6844e8bbbf17b8 rdf:first sg:person.01365743302.13
    215 rdf:rest N5a6d86d4144947a5a11162508bf8d2ad
    216 N90a5ff0d8deb440bb40206e6fa6011fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name In Situ Hybridization
    218 rdf:type schema:DefinedTerm
    219 N9c59c253473a4f53a6b8400d5e4996bb schema:name Springer Nature - SN SciGraph project
    220 rdf:type schema:Organization
    221 Na16c2e3711fd43978fc7cf5f1d9ea8ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Mice
    223 rdf:type schema:DefinedTerm
    224 Nb14c279850494184a0941d4c4c17987a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Dependovirus
    226 rdf:type schema:DefinedTerm
    227 Nb2565c12eb384741a92a5e0e151d21d2 rdf:first sg:person.01321023611.77
    228 rdf:rest Nfbd171e791be4f5d92d1c285d3308815
    229 Nb8ba90881a6b4b74883e7cf6bac7a890 rdf:first sg:person.01071205714.45
    230 rdf:rest Nc0a265ca3105472eb9148b46a9ff6cb7
    231 Nc05aef4441524f4ca329464c4d4d3f04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Phenotype
    233 rdf:type schema:DefinedTerm
    234 Nc0a265ca3105472eb9148b46a9ff6cb7 rdf:first sg:person.01201731244.19
    235 rdf:rest Ncf03d729b9a4418fbf8e439b95c1fe13
    236 Nc464134446714d0b9d788099784e922d rdf:first sg:person.01075663571.52
    237 rdf:rest N88d0a93fdcf2491a9b6844e8bbbf17b8
    238 Nc5bc69cdf38c479f96f5b5409b9d9c10 rdf:first sg:person.01170077066.31
    239 rdf:rest Ne483589a498f4e569a28bbdc749f6e86
    240 Ncf03d729b9a4418fbf8e439b95c1fe13 rdf:first sg:person.0677425671.21
    241 rdf:rest Nc464134446714d0b9d788099784e922d
    242 Nd8019d857c45421589c30102b32f6c6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Male
    244 rdf:type schema:DefinedTerm
    245 Ndb4114a5e0d44ccf9126d89f6006d517 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    246 schema:name Hyperalgesia
    247 rdf:type schema:DefinedTerm
    248 Ne0148fb26b2f41b9b014714a52e5777d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Animals
    250 rdf:type schema:DefinedTerm
    251 Ne483589a498f4e569a28bbdc749f6e86 rdf:first sg:person.01250456513.49
    252 rdf:rest N36db1f8c804f4d33910d86e95798846c
    253 Ne964d04115fb48ea82ddf02a4f896c07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    254 schema:name Polymerase Chain Reaction
    255 rdf:type schema:DefinedTerm
    256 Nf780d02097844089bfd612daf54ce4f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    257 schema:name Acute-Phase Proteins
    258 rdf:type schema:DefinedTerm
    259 Nfbd171e791be4f5d92d1c285d3308815 rdf:first sg:person.0740501552.00
    260 rdf:rest N6656764f62384887ad63ec536997322d
    261 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    262 schema:name Medical and Health Sciences
    263 rdf:type schema:DefinedTerm
    264 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    265 schema:name Neurosciences
    266 rdf:type schema:DefinedTerm
    267 sg:grant.2491499 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3852
    268 rdf:type schema:MonetaryGrant
    269 sg:grant.2558976 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3852
    270 rdf:type schema:MonetaryGrant
    271 sg:grant.2563045 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3852
    272 rdf:type schema:MonetaryGrant
    273 sg:grant.2578969 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3852
    274 rdf:type schema:MonetaryGrant
    275 sg:grant.2636181 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3852
    276 rdf:type schema:MonetaryGrant
    277 sg:grant.3791931 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3852
    278 rdf:type schema:MonetaryGrant
    279 sg:journal.1113716 schema:issn 1078-8956
    280 1546-170X
    281 schema:name Nature Medicine
    282 schema:publisher Springer Nature
    283 rdf:type schema:Periodical
    284 sg:person.01041441555.34 schema:affiliation grid-institutes:grid.2515.3
    285 schema:familyName Costigan
    286 schema:givenName Michael
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041441555.34
    288 rdf:type schema:Person
    289 sg:person.01071205714.45 schema:affiliation grid-institutes:grid.2515.3
    290 schema:familyName Latremoliere
    291 schema:givenName Alban
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01071205714.45
    293 rdf:type schema:Person
    294 sg:person.01075663571.52 schema:affiliation grid-institutes:grid.7700.0
    295 schema:familyName Husainie
    296 schema:givenName Dewi
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075663571.52
    298 rdf:type schema:Person
    299 sg:person.01164225504.68 schema:affiliation grid-institutes:grid.38142.3c
    300 schema:familyName Liberles
    301 schema:givenName Stephen D
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164225504.68
    303 rdf:type schema:Person
    304 sg:person.01170077066.31 schema:affiliation grid-institutes:grid.5253.1
    305 schema:familyName Gehrig
    306 schema:givenName Stefanie
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170077066.31
    308 rdf:type schema:Person
    309 sg:person.01201731244.19 schema:affiliation grid-institutes:grid.7700.0
    310 schema:familyName Bali
    311 schema:givenName Kiran Kumar
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201731244.19
    313 rdf:type schema:Person
    314 sg:person.01212112171.28 schema:affiliation grid-institutes:grid.2515.3
    315 schema:familyName Riva
    316 schema:givenName Priscilla
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212112171.28
    318 rdf:type schema:Person
    319 sg:person.01250456513.49 schema:affiliation grid-institutes:grid.5253.1
    320 schema:familyName Mall
    321 schema:givenName Marcus A
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250456513.49
    323 rdf:type schema:Person
    324 sg:person.01321023611.77 schema:affiliation grid-institutes:grid.9619.7
    325 schema:familyName Devor
    326 schema:givenName Marshall
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01321023611.77
    328 rdf:type schema:Person
    329 sg:person.01347043014.88 schema:affiliation grid-institutes:grid.7497.d
    330 schema:familyName Arnold
    331 schema:givenName Bernd
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347043014.88
    333 rdf:type schema:Person
    334 sg:person.01365743302.13 schema:affiliation grid-institutes:grid.7497.d
    335 schema:familyName Prokosch
    336 schema:givenName Sandra
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365743302.13
    338 rdf:type schema:Person
    339 sg:person.0577073371.77 schema:affiliation grid-institutes:grid.7700.0
    340 schema:familyName Vicuña
    341 schema:givenName Lucas
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577073371.77
    343 rdf:type schema:Person
    344 sg:person.0607245213.51 schema:affiliation grid-institutes:grid.7700.0
    345 schema:familyName Kuner
    346 schema:givenName Rohini
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607245213.51
    348 rdf:type schema:Person
    349 sg:person.0630721070.97 schema:affiliation grid-institutes:grid.38142.3c
    350 schema:familyName Strochlic
    351 schema:givenName David E
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630721070.97
    353 rdf:type schema:Person
    354 sg:person.0677425671.21 schema:affiliation grid-institutes:grid.7700.0
    355 schema:familyName Simonetti
    356 schema:givenName Manuela
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677425671.21
    358 rdf:type schema:Person
    359 sg:person.0721522537.86 schema:affiliation grid-institutes:grid.239915.5
    360 schema:familyName Griffin
    361 schema:givenName Robert S
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721522537.86
    363 rdf:type schema:Person
    364 sg:person.0740501552.00 schema:affiliation grid-institutes:grid.2515.3
    365 schema:familyName Woolf
    366 schema:givenName Clifford J
    367 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740501552.00
    368 rdf:type schema:Person
    369 sg:person.0751254244.47 schema:affiliation grid-institutes:grid.7700.0
    370 schema:familyName Njoo
    371 schema:givenName Christian
    372 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751254244.47
    373 rdf:type schema:Person
    374 sg:pub.10.1038/87440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044718933
    375 https://doi.org/10.1038/87440
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/ncomms3196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048227622
    378 https://doi.org/10.1038/ncomms3196
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/ni.2766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051835983
    381 https://doi.org/10.1038/ni.2766
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/ni1244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032419209
    384 https://doi.org/10.1038/ni1244
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/nm.2159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012728298
    387 https://doi.org/10.1038/nm.2159
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/nm.2710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006175749
    390 https://doi.org/10.1038/nm.2710
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/nm0598-615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048689553
    393 https://doi.org/10.1038/nm0598-615
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nm1490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015312883
    396 https://doi.org/10.1038/nm1490
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nm1723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000974597
    399 https://doi.org/10.1038/nm1723
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/nn1992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006465182
    402 https://doi.org/10.1038/nn1992
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/nri1841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008265635
    405 https://doi.org/10.1038/nri1841
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1186/1471-2202-3-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007072033
    408 https://doi.org/10.1186/1471-2202-3-16
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1186/1742-2094-9-233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003661949
    411 https://doi.org/10.1186/1742-2094-9-233
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1186/gb-2004-5-10-r80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018457673
    414 https://doi.org/10.1186/gb-2004-5-10-r80
    415 rdf:type schema:CreativeWork
    416 sg:pub.10.2119/molmed.2009.00109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068965221
    417 https://doi.org/10.2119/molmed.2009.00109
    418 rdf:type schema:CreativeWork
    419 grid-institutes:grid.239915.5 schema:alternateName Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA.
    420 schema:name Department of Anesthesiology (Pain Management), Hospital for Special Surgery, New York, New York, USA.
    421 rdf:type schema:Organization
    422 grid-institutes:grid.2515.3 schema:alternateName 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
    423 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA.
    424 F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
    425 schema:name 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA.
    426 1] F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA. [3] Department of Anesthesia, Boston Children's Hospital, Boston, Massachusetts, USA.
    427 F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, Massachusetts, USA.
    428 rdf:type schema:Organization
    429 grid-institutes:grid.38142.3c schema:alternateName Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
    430 schema:name Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA.
    431 rdf:type schema:Organization
    432 grid-institutes:grid.5253.1 schema:alternateName Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.
    433 schema:name Department of Translational Pulmonology, Translational Lung Research Center Heidelberg, University of Heidelberg, Heidelberg, Germany.
    434 rdf:type schema:Organization
    435 grid-institutes:grid.7497.d schema:alternateName Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
    436 schema:name Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.
    437 rdf:type schema:Organization
    438 grid-institutes:grid.7700.0 schema:alternateName Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
    439 schema:name Pharmacology Institute, University of Heidelberg, Heidelberg, Germany.
    440 rdf:type schema:Organization
    441 grid-institutes:grid.9619.7 schema:alternateName Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.
    442 schema:name Institute of Life Sciences and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.
    443 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...