An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-04-13

AUTHORS

Alfica Sehgal, Scott Barros, Lacramioara Ivanciu, Brian Cooley, June Qin, Tim Racie, Julia Hettinger, Mary Carioto, Yongfeng Jiang, Josh Brodsky, Harsha Prabhala, Xuemei Zhang, Husain Attarwala, Renta Hutabarat, Don Foster, Stuart Milstein, Klaus Charisse, Satya Kuchimanchi, Martin A Maier, Lubo Nechev, Pachamuthu Kandasamy, Alexander V Kel'in, Jayaprakash K Nair, Kallanthottathil G Rajeev, Muthiah Manoharan, Rachel Meyers, Benny Sorensen, Amy R Simon, Yesim Dargaud, Claude Negrier, Rodney M Camire, Akin Akinc

ABSTRACT

An siRNA targeting antithrombin promotes hemostasis in mouse and nonhuman primate models of hemophilia and could represent a new therapeutic option for this disease.

PAGES

492-497

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.3847

DOI

http://dx.doi.org/10.1038/nm.3847

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014623450

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25849132


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