Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Rintaro Hashizume, Noemi Andor, Yuichiro Ihara, Robin Lerner, Haiyun Gan, Xiaoyue Chen, Dong Fang, Xi Huang, Maxwell W Tom, Vy Ngo, David Solomon, Sabine Mueller, Pamela L Paris, Zhiguo Zhang, Claudia Petritsch, Nalin Gupta, Todd A Waldman, C David James

ABSTRACT

Pediatric brainstem gliomas often harbor oncogenic K27M mutation of histone H3.3. Here we show that GSKJ4 pharmacologic inhibition of K27 demethylase JMJD3 increases cellular H3K27 methylation in K27M tumor cells and demonstrate potent antitumor activity both in vitro against K27M cells and in vivo against K27M xenografts. Our results demonstrate that increasing H3K27 methylation by inhibiting K27 demethylase is a valid therapeutic strategy for treating K27M-expressing brainstem glioma. More... »

PAGES

1394-1396

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.3716

DOI

http://dx.doi.org/10.1038/nm.3716

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046548609

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25401693


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.3716'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.3716'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.3716'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.3716'


 

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338 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
339 schema:name Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
340 Department of Physiology, University of California, San Francisco, San Francisco, California, USA.
341 Department of Urology, University of California, San Francisco, San Francisco, California, USA.
342 rdf:type schema:Organization
343 https://www.grid.ac/institutes/grid.30389.31 schema:alternateName University of California System
344 schema:name Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
345 Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
346 Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.
347 rdf:type schema:Organization
348 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
349 schema:name Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.
350 rdf:type schema:Organization
 




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