Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08-04

AUTHORS

Kevin Pethe, Pablo Bifani, Jichan Jang, Sunhee Kang, Seijin Park, Sujin Ahn, Jan Jiricek, Juyoung Jung, Hee Kyoung Jeon, Jonathan Cechetto, Thierry Christophe, Honggun Lee, Marie Kempf, Mary Jackson, Anne J Lenaerts, Ha Pham, Victoria Jones, Min Jung Seo, Young Mi Kim, Mooyoung Seo, Jeong Jea Seo, Dongsik Park, Yoonae Ko, Inhee Choi, Ryangyeo Kim, Se Yeon Kim, SeungBin Lim, Seung-Ae Yim, Jiyoun Nam, Hwankyu Kang, Haejin Kwon, Chun-Taek Oh, Yoojin Cho, Yunhee Jang, Junghwan Kim, Adeline Chua, Bee Huat Tan, Mahesh B Nanjundappa, Srinivasa P S Rao, Whitney S Barnes, René Wintjens, John R Walker, Sylvie Alonso, Saeyeon Lee, Jungjun Kim, Soohyun Oh, Taegwon Oh, Ulf Nehrbass, Sung-Jun Han, Zaesung No, Jinhwa Lee, Priscille Brodin, Sang-Nae Cho, Kiyean Nam, Jaeseung Kim

ABSTRACT

Tuberculosis kills more than a million people annually, and new treatments are necessary to counter the spread of drug-resistant forms of Mycobacterium tuberculosis. In this issue, Kevin Pethe and his colleagues report their identification of a new antibercular drug, called Q203, that targets the mycobacterial cytochrome bc1 complex and that showed efficacy in vitro and in vivo. More... »

PAGES

1157-1160

Journal

TITLE

Nature Medicine

ISSUE

9

VOLUME

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.3262

DOI

http://dx.doi.org/10.1038/nm.3262

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052261221

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23913123


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38 antibercular drug
39 candidates
40 clinical candidates
41 colleagues
42 cytochrome bc1
43 discovery
44 drug-resistant forms
45 drugs
46 efficacy
47 form
48 identification
49 issues
50 mycobacterial cytochrome bc1
51 new antibercular drug
52 new treatments
53 people
54 potent clinical candidates
55 spread
56 treatment
57 treatment of tuberculosis
58 tuberculosis
59 vitro
60 vivo
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