BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-07

AUTHORS

Martje Tönjes, Sebastian Barbus, Yoon Jung Park, Wei Wang, Magdalena Schlotter, Anders M Lindroth, Sabrina V Pleier, Alfa H C Bai, Daniela Karra, Rosario M Piro, Jörg Felsberg, Adele Addington, Dieter Lemke, Irene Weibrecht, Volker Hovestadt, Claudio G Rolli, Benito Campos, Sevin Turcan, Dominik Sturm, Hendrik Witt, Timothy A Chan, Christel Herold-Mende, Ralf Kemkemer, Rainer König, Kathrin Schmidt, William-Edmund Hull, Stefan M Pfister, Manfred Jugold, Susan M Hutson, Christoph Plass, Jürgen G Okun, Guido Reifenberger, Peter Lichter, Bernhard Radlwimmer

ABSTRACT

Here we show that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs). Expression of BCAT1 was exclusive to tumors carrying wild-type isocitrate dehydrogenase 1 (IDH1) and IDH2 genes and was highly correlated with methylation patterns in the BCAT1 promoter region. BCAT1 expression was dependent on the concentration of α-ketoglutarate substrate in glioma cell lines and could be suppressed by ectopic overexpression of mutant IDH1 in immortalized human astrocytes, providing a link between IDH1 function and BCAT1 expression. Suppression of BCAT1 in glioma cell lines blocked the excretion of glutamate and led to reduced proliferation and invasiveness in vitro, as well as significant decreases in tumor growth in a glioblastoma xenograft model. These findings suggest a central role for BCAT1 in glioma pathogenesis, making BCAT1 and BCAA metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma. More... »

PAGES

901-908

References to SciGraph publications

  • 2008-12. Analysis of the IDH1 codon 132 mutation in brain tumors in ACTA NEUROPATHOLOGICA
  • 2010-12. Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas in ACTA NEUROPATHOLOGICA
  • 2012-03. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype in NATURE
  • 2011-10. Glutamate release by primary brain tumors induces epileptic activity in NATURE MEDICINE
  • 2009-10. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas in ACTA NEUROPATHOLOGICA
  • 2010-01. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer in ONCOGENE
  • 2009-11. Monoclonal antibody specific for IDH1 R132H mutation in ACTA NEUROPATHOLOGICA
  • 2012-03. IDH mutation impairs histone demethylation and results in a block to cell differentiation in NATURE
  • 2012-04. MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma in ACTA NEUROPATHOLOGICA
  • 2011-09. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis in NATURE GENETICS
  • 2012-01. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia in NATURE
  • 2012-08. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics in NATURE
  • 2012-01. Reductive carboxylation supports growth in tumour cells with defective mitochondria in NATURE
  • 2009-12. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate in NATURE
  • 2011-05. Otto Warburg's contributions to current concepts of cancer metabolism in NATURE REVIEWS CANCER
  • 2001-04. Identification of amplified genes from SV40 large T antigen-induced rat PNET cell lines by subtractive cDNA analysis and radiation hybrid mapping in ONCOGENE
  • 2011-08. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.3217

    DOI

    http://dx.doi.org/10.1038/nm.3217

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018926427

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23793099


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acids, Branched-Chain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Proliferation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glioma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "HEK293 Cells", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Isocitrate Dehydrogenase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Metabolism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice, Nude", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Models, Biological", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transaminases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "T\u00f6njes", 
            "givenName": "Martje", 
            "id": "sg:person.0630674421.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630674421.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barbus", 
            "givenName": "Sebastian", 
            "id": "sg:person.01203016421.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203016421.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ewha Womans University", 
              "id": "https://www.grid.ac/institutes/grid.255649.9", 
              "name": [
                "Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.", 
                "Department of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul, South Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Yoon Jung", 
            "id": "sg:person.01112207251.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112207251.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "Wei", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schlotter", 
            "givenName": "Magdalena", 
            "id": "sg:person.01255310100.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255310100.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lindroth", 
            "givenName": "Anders M", 
            "id": "sg:person.011651452220.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651452220.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.", 
                "Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pleier", 
            "givenName": "Sabrina V", 
            "id": "sg:person.0776666115.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776666115.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bai", 
            "givenName": "Alfa H C", 
            "id": "sg:person.0750540507.77", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750540507.77"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Neuropathology, Heinrich Heine University, D\u00fcsseldorf, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Karra", 
            "givenName": "Daniela", 
            "id": "sg:person.0645540247.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645540247.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.", 
                "Division of Theoretical Bioinformatics, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Piro", 
            "givenName": "Rosario M", 
            "id": "sg:person.0714253406.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714253406.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heinrich Heine University D\u00fcsseldorf", 
              "id": "https://www.grid.ac/institutes/grid.411327.2", 
              "name": [
                "Department of Neuropathology, Heinrich Heine University, D\u00fcsseldorf, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Felsberg", 
            "givenName": "J\u00f6rg", 
            "id": "sg:person.01314516075.28", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314516075.28"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virginia Tech", 
              "id": "https://www.grid.ac/institutes/grid.438526.e", 
              "name": [
                "Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute, Blacksburg, Virginia, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Addington", 
            "givenName": "Adele", 
            "id": "sg:person.01205626760.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205626760.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lemke", 
            "givenName": "Dieter", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weibrecht", 
            "givenName": "Irene", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hovestadt", 
            "givenName": "Volker", 
            "id": "sg:person.0610463215.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610463215.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Intelligent Systems", 
              "id": "https://www.grid.ac/institutes/grid.419534.e", 
              "name": [
                "Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rolli", 
            "givenName": "Claudio G", 
            "id": "sg:person.01133102307.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133102307.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.", 
                "Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Campos", 
            "givenName": "Benito", 
            "id": "sg:person.01360315353.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360315353.00"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Turcan", 
            "givenName": "Sevin", 
            "id": "sg:person.01207137341.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207137341.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.", 
                "Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.", 
                "Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sturm", 
            "givenName": "Dominik", 
            "id": "sg:person.01124352515.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124352515.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.", 
                "Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.", 
                "Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Witt", 
            "givenName": "Hendrik", 
            "id": "sg:person.0757363774.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757363774.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan Kettering Cancer Center", 
              "id": "https://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chan", 
            "givenName": "Timothy A", 
            "id": "sg:person.01265335422.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265335422.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Heidelberg University", 
              "id": "https://www.grid.ac/institutes/grid.7700.0", 
              "name": [
                "Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.", 
                "Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herold-Mende", 
            "givenName": "Christel", 
            "id": "sg:person.0767624634.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767624634.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Reutlingen University", 
              "id": "https://www.grid.ac/institutes/grid.434088.3", 
              "name": [
                "Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.", 
                "Reutlingen University of Applied Science, Reutlingen, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kemkemer", 
            "givenName": "Ralf", 
            "id": "sg:person.01204541513.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204541513.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.", 
                "Division of Theoretical Bioinformatics, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "K\u00f6nig", 
            "givenName": "Rainer", 
            "id": "sg:person.01225130125.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225130125.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schmidt", 
            "givenName": "Kathrin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Core Facility, Molecular Structural Analysis, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hull", 
            "givenName": "William-Edmund", 
            "id": "sg:person.0656770604.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656770604.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.", 
                "Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.", 
                "Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pfister", 
            "givenName": "Stefan M", 
            "id": "sg:person.01105171247.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105171247.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Core Facility, Small Animal Imaging Center, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jugold", 
            "givenName": "Manfred", 
            "id": "sg:person.0576716227.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576716227.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Virginia Tech", 
              "id": "https://www.grid.ac/institutes/grid.438526.e", 
              "name": [
                "Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute, Blacksburg, Virginia, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hutson", 
            "givenName": "Susan M", 
            "id": "sg:person.016013273277.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016013273277.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Plass", 
            "givenName": "Christoph", 
            "id": "sg:person.01047735151.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047735151.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University Hospital Heidelberg", 
              "id": "https://www.grid.ac/institutes/grid.5253.1", 
              "name": [
                "Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okun", 
            "givenName": "J\u00fcrgen G", 
            "id": "sg:person.01022514741.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022514741.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Department of Neuropathology, Heinrich Heine University, D\u00fcsseldorf, Germany.", 
                "German Cancer Consortium (DKTK), DKFZ, Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Reifenberger", 
            "givenName": "Guido", 
            "id": "sg:person.07524506162.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07524506162.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lichter", 
            "givenName": "Peter", 
            "id": "sg:person.01243467607.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243467607.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "German Cancer Research Center", 
              "id": "https://www.grid.ac/institutes/grid.7497.d", 
              "name": [
                "Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Radlwimmer", 
            "givenName": "Bernhard", 
            "id": "sg:person.0642756445.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642756445.92"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature10860", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000103968", 
              "https://doi.org/10.1038/nature10860"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.c.30086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001481352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajmg.c.30086", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001481352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0561-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005128955", 
              "https://doi.org/10.1007/s00401-009-0561-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0561-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005128955", 
              "https://doi.org/10.1007/s00401-009-0561-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.890", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006974173", 
              "https://doi.org/10.1038/ng.890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m506486200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007342499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m506486200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007342499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0810199105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007462431"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.2001.00156.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007949438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0595-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008042846", 
              "https://doi.org/10.1007/s00401-009-0595-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-009-0595-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008042846", 
              "https://doi.org/10.1007/s00401-009-0595-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008995827", 
              "https://doi.org/10.1038/nrc3038"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.12.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009110560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0507816102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009416951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0507816102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009416951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature11323", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009726441", 
              "https://doi.org/10.1038/nature11323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.11.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010196923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djq187", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010611295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010733927", 
              "https://doi.org/10.1038/nature10866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20061506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011999534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj20061506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011999534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.9.4982", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014217323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016008729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pmic.200800902", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016008729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016136939", 
              "https://doi.org/10.1038/nature08617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08617", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016136939", 
              "https://doi.org/10.1038/nature08617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0709747104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016350654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molmed.2010.07.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016375042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1019393108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017876854"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0007752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018946723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0008726", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019426788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.04332.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021664720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023081409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024016716"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1170944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025009423"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1218595", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025191587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1471-4159.1998.71020863.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026252307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.00276.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029800022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1800", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031254541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.198200.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033943545"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2007.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035229222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0808710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035319148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039224613", 
              "https://doi.org/10.1038/sj.onc.1204287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1204287", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039224613", 
              "https://doi.org/10.1038/sj.onc.1204287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nop007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039320053"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040629839"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040778422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2009.358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041066726", 
              "https://doi.org/10.1038/onc.2009.358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25448", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043120298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1215/15228517-2009-025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043122141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-010-0781-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043129373", 
              "https://doi.org/10.1007/s00401-010-0781-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-010-0781-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043129373", 
              "https://doi.org/10.1007/s00401-010-0781-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1117773108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043292855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1215/15228517-2008-032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044393210"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2010.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044538954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.03813.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044780690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.03813.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044780690"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4889(90)90240-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045028731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-4889(90)90240-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045028731"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.2453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045398326", 
              "https://doi.org/10.1038/nm.2453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045502595", 
              "https://doi.org/10.1038/nature10350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2008.05301.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045581833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-008-0455-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047349518", 
              "https://doi.org/10.1007/s00401-008-0455-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0924-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047732842", 
              "https://doi.org/10.1007/s00401-011-0924-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164382", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048029720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10642", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050053957", 
              "https://doi.org/10.1038/nature10642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-1666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051110747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2012.08.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052838309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10602", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053544093", 
              "https://doi.org/10.1038/nature10602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.122.3168.501", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062466253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v12.i36.5884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071365023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.3.7701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300547"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jn/135.6.1557s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077060426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3727/000000007783980873", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077532388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078048625", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080137536", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081444389", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/oxfordjournals.jbchem.a128277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081458377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082783475", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcn/68.1.72", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083291431"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-07", 
        "datePublishedReg": "2013-07-01", 
        "description": "Here we show that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs). Expression of BCAT1 was exclusive to tumors carrying wild-type isocitrate dehydrogenase 1 (IDH1) and IDH2 genes and was highly correlated with methylation patterns in the BCAT1 promoter region. BCAT1 expression was dependent on the concentration of \u03b1-ketoglutarate substrate in glioma cell lines and could be suppressed by ectopic overexpression of mutant IDH1 in immortalized human astrocytes, providing a link between IDH1 function and BCAT1 expression. Suppression of BCAT1 in glioma cell lines blocked the excretion of glutamate and led to reduced proliferation and invasiveness in vitro, as well as significant decreases in tumor growth in a glioblastoma xenograft model. These findings suggest a central role for BCAT1 in glioma pathogenesis, making BCAT1 and BCAA metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm.3217", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2682833", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "name": "BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1", 
        "pagination": "901-908", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "5a2d8b926e4cd692237569fd65a5631002601afdfc970deabede811a26217e64"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23793099"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm.3217"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1018926427"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm.3217", 
          "https://app.dimensions.ai/details/publication/pub.1018926427"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nm.3217"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.3217'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.3217'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.3217'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.3217'


     

    This table displays all metadata directly associated to this object as RDF triples.

    619 TRIPLES      21 PREDICATES      114 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm.3217 schema:about N052e27f5bbda4bb1b099e01455e7c678
    2 N343d19f41912451faf1587d6890d6b68
    3 N34a564017c7b4b5d957fe73f00806dd8
    4 N4c7714c30b1b4a7ca65140b66023adbd
    5 N69c1200999de4b509ca3d3bf417b2f26
    6 N7084a7d134074d518bc0eaf04f059f44
    7 N775621bcd701460cb9fee5b61e27e54f
    8 Nb7db9b227dd843dfae38c54f8014322f
    9 Nbff3a582703444528a994ac0752d4dbd
    10 Nc2a3220ee63d4d4abe6e21b030aee58c
    11 Nc968433ba49d4d9a9eadfac334690e5e
    12 Nca9efb38df0c4864ac453cd7bcc21e76
    13 Nd715f28a9bcf4178a8a6705d8cc43356
    14 Nd82c746cc62c42788d7f6c0319e49020
    15 Nfc9569d7fb2e4fb789f679f141b580d0
    16 anzsrc-for:06
    17 anzsrc-for:0601
    18 schema:author N1eb80cb00a0a4da0bff6022b53bfcab6
    19 schema:citation sg:pub.10.1007/s00401-008-0455-2
    20 sg:pub.10.1007/s00401-009-0561-9
    21 sg:pub.10.1007/s00401-009-0595-z
    22 sg:pub.10.1007/s00401-010-0781-z
    23 sg:pub.10.1007/s00401-011-0924-x
    24 sg:pub.10.1038/nature08617
    25 sg:pub.10.1038/nature10350
    26 sg:pub.10.1038/nature10602
    27 sg:pub.10.1038/nature10642
    28 sg:pub.10.1038/nature10860
    29 sg:pub.10.1038/nature10866
    30 sg:pub.10.1038/nature11323
    31 sg:pub.10.1038/ng.890
    32 sg:pub.10.1038/nm.2453
    33 sg:pub.10.1038/nrc3038
    34 sg:pub.10.1038/onc.2009.358
    35 sg:pub.10.1038/sj.onc.1204287
    36 https://app.dimensions.ai/details/publication/pub.1076750128
    37 https://app.dimensions.ai/details/publication/pub.1078048625
    38 https://app.dimensions.ai/details/publication/pub.1080137536
    39 https://app.dimensions.ai/details/publication/pub.1081444389
    40 https://app.dimensions.ai/details/publication/pub.1082783475
    41 https://doi.org/10.1002/ajmg.c.30086
    42 https://doi.org/10.1002/ijc.25448
    43 https://doi.org/10.1002/pmic.200800902
    44 https://doi.org/10.1016/0167-4889(90)90240-e
    45 https://doi.org/10.1016/j.ccr.2009.12.020
    46 https://doi.org/10.1016/j.ccr.2010.03.017
    47 https://doi.org/10.1016/j.ccr.2010.11.015
    48 https://doi.org/10.1016/j.ccr.2010.12.014
    49 https://doi.org/10.1016/j.ccr.2012.08.024
    50 https://doi.org/10.1016/j.cmet.2007.08.003
    51 https://doi.org/10.1016/j.molmed.2010.07.002
    52 https://doi.org/10.1042/bj20061506
    53 https://doi.org/10.1046/j.1471-4159.1998.71020863.x
    54 https://doi.org/10.1046/j.1471-4159.2001.00156.x
    55 https://doi.org/10.1056/nejmoa0808710
    56 https://doi.org/10.1073/pnas.0507816102
    57 https://doi.org/10.1073/pnas.0709747104
    58 https://doi.org/10.1073/pnas.0810199105
    59 https://doi.org/10.1073/pnas.1019393108
    60 https://doi.org/10.1073/pnas.1117773108
    61 https://doi.org/10.1074/jbc.273.9.4982
    62 https://doi.org/10.1074/jbc.m506486200
    63 https://doi.org/10.1093/ajcn/68.1.72
    64 https://doi.org/10.1093/bioinformatics/btq113
    65 https://doi.org/10.1093/jn/135.6.1557s
    66 https://doi.org/10.1093/jnci/djq187
    67 https://doi.org/10.1093/neuonc/nop007
    68 https://doi.org/10.1093/oxfordjournals.jbchem.a128277
    69 https://doi.org/10.1101/gad.198200.112
    70 https://doi.org/10.1111/j.1471-4159.2006.03813.x
    71 https://doi.org/10.1111/j.1471-4159.2006.04332.x
    72 https://doi.org/10.1111/j.1471-4159.2008.05301.x
    73 https://doi.org/10.1126/science.1164382
    74 https://doi.org/10.1126/science.1170944
    75 https://doi.org/10.1126/science.1218595
    76 https://doi.org/10.1126/science.122.3168.501
    77 https://doi.org/10.1152/ajpendo.00276.2003
    78 https://doi.org/10.1158/0008-5472.can-09-2266
    79 https://doi.org/10.1158/0008-5472.can-09-2307
    80 https://doi.org/10.1158/0008-5472.can-10-1666
    81 https://doi.org/10.1158/1078-0432.ccr-09-1800
    82 https://doi.org/10.1215/15228517-2008-032
    83 https://doi.org/10.1215/15228517-2009-025
    84 https://doi.org/10.1371/journal.pone.0007752
    85 https://doi.org/10.1371/journal.pone.0008726
    86 https://doi.org/10.3727/000000007783980873
    87 https://doi.org/10.3748/wjg.v12.i36.5884
    88 https://doi.org/10.4161/cc.8.3.7701
    89 schema:datePublished 2013-07
    90 schema:datePublishedReg 2013-07-01
    91 schema:description Here we show that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs). Expression of BCAT1 was exclusive to tumors carrying wild-type isocitrate dehydrogenase 1 (IDH1) and IDH2 genes and was highly correlated with methylation patterns in the BCAT1 promoter region. BCAT1 expression was dependent on the concentration of α-ketoglutarate substrate in glioma cell lines and could be suppressed by ectopic overexpression of mutant IDH1 in immortalized human astrocytes, providing a link between IDH1 function and BCAT1 expression. Suppression of BCAT1 in glioma cell lines blocked the excretion of glutamate and led to reduced proliferation and invasiveness in vitro, as well as significant decreases in tumor growth in a glioblastoma xenograft model. These findings suggest a central role for BCAT1 in glioma pathogenesis, making BCAT1 and BCAA metabolism attractive targets for the development of targeted therapeutic approaches to treat patients with glioblastoma.
    92 schema:genre research_article
    93 schema:inLanguage en
    94 schema:isAccessibleForFree true
    95 schema:isPartOf Na72c988a316d4cb5be2c3510341df002
    96 Nbd38becb978f4147874b2e27ed578711
    97 sg:journal.1113716
    98 schema:name BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
    99 schema:pagination 901-908
    100 schema:productId N2f55e5e3672f41dfabb2062780facfe8
    101 N6cce3eb93e3f463f9ba9721bbc25f24e
    102 Na50aa835b8e6403599e7cd8e74ead82f
    103 Nbccd1c9add094ed6b48538fcdfb68ee4
    104 Nf1e6409a7e0e40a49456d7c8113fabbc
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018926427
    106 https://doi.org/10.1038/nm.3217
    107 schema:sdDatePublished 2019-04-11T01:46
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher Neb69a502dd1c4c4887f4d4b2139d03c7
    110 schema:url http://www.nature.com/articles/nm.3217
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N052e27f5bbda4bb1b099e01455e7c678 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Brain Neoplasms
    116 rdf:type schema:DefinedTerm
    117 N0d07290df521412da13e3e9e0682fc0b rdf:first N1811e0766fd945438ffdd37b8b2bfcd0
    118 rdf:rest N6743f41b04ca45e4963c06210007dfd4
    119 N1811e0766fd945438ffdd37b8b2bfcd0 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    120 schema:familyName Lemke
    121 schema:givenName Dieter
    122 rdf:type schema:Person
    123 N1eb80cb00a0a4da0bff6022b53bfcab6 rdf:first sg:person.0630674421.55
    124 rdf:rest N54d76e62fa534ed4bcbe2d30bac56ca4
    125 N220ecab37d2945f498d4fb87af0556b7 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    126 schema:familyName Schmidt
    127 schema:givenName Kathrin
    128 rdf:type schema:Person
    129 N2307759877ee404bbf15a138a56e3917 rdf:first sg:person.0776666115.51
    130 rdf:rest N90d3270a21334579b7663717550054e5
    131 N256f47b1d9184691b17551448c288eb6 rdf:first sg:person.0757363774.37
    132 rdf:rest N59d5bc9e5dd641d387445da925634efe
    133 N2be4c0445ee346ea93aaa3e377cfdeb4 rdf:first sg:person.01124352515.36
    134 rdf:rest N256f47b1d9184691b17551448c288eb6
    135 N2f55e5e3672f41dfabb2062780facfe8 schema:name dimensions_id
    136 schema:value pub.1018926427
    137 rdf:type schema:PropertyValue
    138 N34138b306a904940a57b5325bc0986e4 rdf:first sg:person.01047735151.14
    139 rdf:rest N88fb36ca93fb4c4ba43d9cf1155c8e70
    140 N343d19f41912451faf1587d6890d6b68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Isocitrate Dehydrogenase
    142 rdf:type schema:DefinedTerm
    143 N34a564017c7b4b5d957fe73f00806dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Amino Acids, Branched-Chain
    145 rdf:type schema:DefinedTerm
    146 N369554e3709d40f7a71ac293f9162a59 rdf:first sg:person.01314516075.28
    147 rdf:rest N571242db578d47d5a8da691590d1cf33
    148 N4b4787a83c4b45b1b8da491fc3be892c rdf:first sg:person.0714253406.39
    149 rdf:rest N369554e3709d40f7a71ac293f9162a59
    150 N4c7714c30b1b4a7ca65140b66023adbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Models, Biological
    152 rdf:type schema:DefinedTerm
    153 N54d76e62fa534ed4bcbe2d30bac56ca4 rdf:first sg:person.01203016421.50
    154 rdf:rest N5a8a849abe874de38f0ae158d2d34905
    155 N571242db578d47d5a8da691590d1cf33 rdf:first sg:person.01205626760.86
    156 rdf:rest N0d07290df521412da13e3e9e0682fc0b
    157 N58dcba130fd24b0382ede2fa6ab0bc05 rdf:first sg:person.01225130125.13
    158 rdf:rest Ncfc1b720aafd4f8fabd017b9251657c7
    159 N59d5bc9e5dd641d387445da925634efe rdf:first sg:person.01265335422.08
    160 rdf:rest Naf4d7295fce34428beebf7a85254ff5d
    161 N5a1c150f885f46199a31098e484451b6 rdf:first sg:person.01133102307.60
    162 rdf:rest Ne6d3474f14cd4a23a1e4f7e3618780ed
    163 N5a8a849abe874de38f0ae158d2d34905 rdf:first sg:person.01112207251.05
    164 rdf:rest Nf6e64ad87f43480a93dea5cf248b4d07
    165 N672e4b843637489d8585ae195f3d2207 rdf:first sg:person.0642756445.92
    166 rdf:rest rdf:nil
    167 N6743f41b04ca45e4963c06210007dfd4 rdf:first N86316251dbe142d9a94026c6cf624c3f
    168 rdf:rest Ncc047ac1be3145d5a1ce069e72bc9662
    169 N69c1200999de4b509ca3d3bf417b2f26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Female
    171 rdf:type schema:DefinedTerm
    172 N6cce3eb93e3f463f9ba9721bbc25f24e schema:name readcube_id
    173 schema:value 5a2d8b926e4cd692237569fd65a5631002601afdfc970deabede811a26217e64
    174 rdf:type schema:PropertyValue
    175 N7084a7d134074d518bc0eaf04f059f44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Animals
    177 rdf:type schema:DefinedTerm
    178 N75f3ee8df7034d36a59b41469ba0c2ee rdf:first sg:person.01105171247.76
    179 rdf:rest Nf957e43031af4f0c9c78392aef7a212e
    180 N775621bcd701460cb9fee5b61e27e54f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Transaminases
    182 rdf:type schema:DefinedTerm
    183 N7d7848ebd30546e18791ab1b833642b7 rdf:first sg:person.01207137341.14
    184 rdf:rest N2be4c0445ee346ea93aaa3e377cfdeb4
    185 N84bcaedb497147b89a85894c2290b57f rdf:first sg:person.0645540247.65
    186 rdf:rest N4b4787a83c4b45b1b8da491fc3be892c
    187 N86316251dbe142d9a94026c6cf624c3f schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    188 schema:familyName Weibrecht
    189 schema:givenName Irene
    190 rdf:type schema:Person
    191 N875daf0faccb4563bd3ec904790314c2 rdf:first sg:person.01243467607.83
    192 rdf:rest N672e4b843637489d8585ae195f3d2207
    193 N88fb36ca93fb4c4ba43d9cf1155c8e70 rdf:first sg:person.01022514741.41
    194 rdf:rest N9be8393c94ce49889d9700545e907237
    195 N90d3270a21334579b7663717550054e5 rdf:first sg:person.0750540507.77
    196 rdf:rest N84bcaedb497147b89a85894c2290b57f
    197 N9be8393c94ce49889d9700545e907237 rdf:first sg:person.07524506162.54
    198 rdf:rest N875daf0faccb4563bd3ec904790314c2
    199 Na0c473908fb34f5480b3e2a0463dc990 rdf:first sg:person.01255310100.81
    200 rdf:rest Nba48878c802649a7976b790ed43fa81d
    201 Na50aa835b8e6403599e7cd8e74ead82f schema:name pubmed_id
    202 schema:value 23793099
    203 rdf:type schema:PropertyValue
    204 Na681aea237094d02a5dfbaa9269c6603 rdf:first sg:person.0656770604.03
    205 rdf:rest N75f3ee8df7034d36a59b41469ba0c2ee
    206 Na72c988a316d4cb5be2c3510341df002 schema:issueNumber 7
    207 rdf:type schema:PublicationIssue
    208 Naf4d7295fce34428beebf7a85254ff5d rdf:first sg:person.0767624634.57
    209 rdf:rest Nd96d8b325c514d8a867c0c27b85fe61a
    210 Nb7db9b227dd843dfae38c54f8014322f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Cell Line, Tumor
    212 rdf:type schema:DefinedTerm
    213 Nba48878c802649a7976b790ed43fa81d rdf:first sg:person.011651452220.13
    214 rdf:rest N2307759877ee404bbf15a138a56e3917
    215 Nbccd1c9add094ed6b48538fcdfb68ee4 schema:name doi
    216 schema:value 10.1038/nm.3217
    217 rdf:type schema:PropertyValue
    218 Nbd38becb978f4147874b2e27ed578711 schema:volumeNumber 19
    219 rdf:type schema:PublicationVolume
    220 Nbff3a582703444528a994ac0752d4dbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Glioma
    222 rdf:type schema:DefinedTerm
    223 Nc2a3220ee63d4d4abe6e21b030aee58c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name HEK293 Cells
    225 rdf:type schema:DefinedTerm
    226 Nc7d09832173544d4840265535e409f32 rdf:first sg:person.016013273277.10
    227 rdf:rest N34138b306a904940a57b5325bc0986e4
    228 Nc968433ba49d4d9a9eadfac334690e5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Humans
    230 rdf:type schema:DefinedTerm
    231 Nca9efb38df0c4864ac453cd7bcc21e76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Mice
    233 rdf:type schema:DefinedTerm
    234 Ncc047ac1be3145d5a1ce069e72bc9662 rdf:first sg:person.0610463215.17
    235 rdf:rest N5a1c150f885f46199a31098e484451b6
    236 Ncfc1b720aafd4f8fabd017b9251657c7 rdf:first N220ecab37d2945f498d4fb87af0556b7
    237 rdf:rest Na681aea237094d02a5dfbaa9269c6603
    238 Nd715f28a9bcf4178a8a6705d8cc43356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Mice, Nude
    240 rdf:type schema:DefinedTerm
    241 Nd82c746cc62c42788d7f6c0319e49020 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Metabolism
    243 rdf:type schema:DefinedTerm
    244 Nd96d8b325c514d8a867c0c27b85fe61a rdf:first sg:person.01204541513.25
    245 rdf:rest N58dcba130fd24b0382ede2fa6ab0bc05
    246 Ne6d3474f14cd4a23a1e4f7e3618780ed rdf:first sg:person.01360315353.00
    247 rdf:rest N7d7848ebd30546e18791ab1b833642b7
    248 Neb69a502dd1c4c4887f4d4b2139d03c7 schema:name Springer Nature - SN SciGraph project
    249 rdf:type schema:Organization
    250 Nf1e6409a7e0e40a49456d7c8113fabbc schema:name nlm_unique_id
    251 schema:value 9502015
    252 rdf:type schema:PropertyValue
    253 Nf6e64ad87f43480a93dea5cf248b4d07 rdf:first Nf7b67f92864f495994a408519f2dca2a
    254 rdf:rest Na0c473908fb34f5480b3e2a0463dc990
    255 Nf7b67f92864f495994a408519f2dca2a schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    256 schema:familyName Wang
    257 schema:givenName Wei
    258 rdf:type schema:Person
    259 Nf957e43031af4f0c9c78392aef7a212e rdf:first sg:person.0576716227.60
    260 rdf:rest Nc7d09832173544d4840265535e409f32
    261 Nfc9569d7fb2e4fb789f679f141b580d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Cell Proliferation
    263 rdf:type schema:DefinedTerm
    264 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    265 schema:name Biological Sciences
    266 rdf:type schema:DefinedTerm
    267 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    268 schema:name Biochemistry and Cell Biology
    269 rdf:type schema:DefinedTerm
    270 sg:grant.2682833 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3217
    271 rdf:type schema:MonetaryGrant
    272 sg:journal.1113716 schema:issn 1078-8956
    273 1546-170X
    274 schema:name Nature Medicine
    275 rdf:type schema:Periodical
    276 sg:person.01022514741.41 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    277 schema:familyName Okun
    278 schema:givenName Jürgen G
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022514741.41
    280 rdf:type schema:Person
    281 sg:person.01047735151.14 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    282 schema:familyName Plass
    283 schema:givenName Christoph
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047735151.14
    285 rdf:type schema:Person
    286 sg:person.01105171247.76 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    287 schema:familyName Pfister
    288 schema:givenName Stefan M
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105171247.76
    290 rdf:type schema:Person
    291 sg:person.01112207251.05 schema:affiliation https://www.grid.ac/institutes/grid.255649.9
    292 schema:familyName Park
    293 schema:givenName Yoon Jung
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112207251.05
    295 rdf:type schema:Person
    296 sg:person.01124352515.36 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    297 schema:familyName Sturm
    298 schema:givenName Dominik
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124352515.36
    300 rdf:type schema:Person
    301 sg:person.01133102307.60 schema:affiliation https://www.grid.ac/institutes/grid.419534.e
    302 schema:familyName Rolli
    303 schema:givenName Claudio G
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133102307.60
    305 rdf:type schema:Person
    306 sg:person.011651452220.13 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    307 schema:familyName Lindroth
    308 schema:givenName Anders M
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011651452220.13
    310 rdf:type schema:Person
    311 sg:person.01203016421.50 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    312 schema:familyName Barbus
    313 schema:givenName Sebastian
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203016421.50
    315 rdf:type schema:Person
    316 sg:person.01204541513.25 schema:affiliation https://www.grid.ac/institutes/grid.434088.3
    317 schema:familyName Kemkemer
    318 schema:givenName Ralf
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204541513.25
    320 rdf:type schema:Person
    321 sg:person.01205626760.86 schema:affiliation https://www.grid.ac/institutes/grid.438526.e
    322 schema:familyName Addington
    323 schema:givenName Adele
    324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205626760.86
    325 rdf:type schema:Person
    326 sg:person.01207137341.14 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    327 schema:familyName Turcan
    328 schema:givenName Sevin
    329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207137341.14
    330 rdf:type schema:Person
    331 sg:person.01225130125.13 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    332 schema:familyName König
    333 schema:givenName Rainer
    334 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225130125.13
    335 rdf:type schema:Person
    336 sg:person.01243467607.83 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    337 schema:familyName Lichter
    338 schema:givenName Peter
    339 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243467607.83
    340 rdf:type schema:Person
    341 sg:person.01255310100.81 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    342 schema:familyName Schlotter
    343 schema:givenName Magdalena
    344 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255310100.81
    345 rdf:type schema:Person
    346 sg:person.01265335422.08 schema:affiliation https://www.grid.ac/institutes/grid.51462.34
    347 schema:familyName Chan
    348 schema:givenName Timothy A
    349 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01265335422.08
    350 rdf:type schema:Person
    351 sg:person.01314516075.28 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    352 schema:familyName Felsberg
    353 schema:givenName Jörg
    354 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314516075.28
    355 rdf:type schema:Person
    356 sg:person.01360315353.00 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    357 schema:familyName Campos
    358 schema:givenName Benito
    359 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01360315353.00
    360 rdf:type schema:Person
    361 sg:person.016013273277.10 schema:affiliation https://www.grid.ac/institutes/grid.438526.e
    362 schema:familyName Hutson
    363 schema:givenName Susan M
    364 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016013273277.10
    365 rdf:type schema:Person
    366 sg:person.0576716227.60 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    367 schema:familyName Jugold
    368 schema:givenName Manfred
    369 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576716227.60
    370 rdf:type schema:Person
    371 sg:person.0610463215.17 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    372 schema:familyName Hovestadt
    373 schema:givenName Volker
    374 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610463215.17
    375 rdf:type schema:Person
    376 sg:person.0630674421.55 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    377 schema:familyName Tönjes
    378 schema:givenName Martje
    379 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0630674421.55
    380 rdf:type schema:Person
    381 sg:person.0642756445.92 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    382 schema:familyName Radlwimmer
    383 schema:givenName Bernhard
    384 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642756445.92
    385 rdf:type schema:Person
    386 sg:person.0645540247.65 schema:affiliation https://www.grid.ac/institutes/grid.411327.2
    387 schema:familyName Karra
    388 schema:givenName Daniela
    389 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645540247.65
    390 rdf:type schema:Person
    391 sg:person.0656770604.03 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    392 schema:familyName Hull
    393 schema:givenName William-Edmund
    394 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656770604.03
    395 rdf:type schema:Person
    396 sg:person.0714253406.39 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    397 schema:familyName Piro
    398 schema:givenName Rosario M
    399 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714253406.39
    400 rdf:type schema:Person
    401 sg:person.0750540507.77 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    402 schema:familyName Bai
    403 schema:givenName Alfa H C
    404 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750540507.77
    405 rdf:type schema:Person
    406 sg:person.07524506162.54 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    407 schema:familyName Reifenberger
    408 schema:givenName Guido
    409 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07524506162.54
    410 rdf:type schema:Person
    411 sg:person.0757363774.37 schema:affiliation https://www.grid.ac/institutes/grid.5253.1
    412 schema:familyName Witt
    413 schema:givenName Hendrik
    414 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757363774.37
    415 rdf:type schema:Person
    416 sg:person.0767624634.57 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
    417 schema:familyName Herold-Mende
    418 schema:givenName Christel
    419 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767624634.57
    420 rdf:type schema:Person
    421 sg:person.0776666115.51 schema:affiliation https://www.grid.ac/institutes/grid.7497.d
    422 schema:familyName Pleier
    423 schema:givenName Sabrina V
    424 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0776666115.51
    425 rdf:type schema:Person
    426 sg:pub.10.1007/s00401-008-0455-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047349518
    427 https://doi.org/10.1007/s00401-008-0455-2
    428 rdf:type schema:CreativeWork
    429 sg:pub.10.1007/s00401-009-0561-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005128955
    430 https://doi.org/10.1007/s00401-009-0561-9
    431 rdf:type schema:CreativeWork
    432 sg:pub.10.1007/s00401-009-0595-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1008042846
    433 https://doi.org/10.1007/s00401-009-0595-z
    434 rdf:type schema:CreativeWork
    435 sg:pub.10.1007/s00401-010-0781-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043129373
    436 https://doi.org/10.1007/s00401-010-0781-z
    437 rdf:type schema:CreativeWork
    438 sg:pub.10.1007/s00401-011-0924-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047732842
    439 https://doi.org/10.1007/s00401-011-0924-x
    440 rdf:type schema:CreativeWork
    441 sg:pub.10.1038/nature08617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016136939
    442 https://doi.org/10.1038/nature08617
    443 rdf:type schema:CreativeWork
    444 sg:pub.10.1038/nature10350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045502595
    445 https://doi.org/10.1038/nature10350
    446 rdf:type schema:CreativeWork
    447 sg:pub.10.1038/nature10602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053544093
    448 https://doi.org/10.1038/nature10602
    449 rdf:type schema:CreativeWork
    450 sg:pub.10.1038/nature10642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050053957
    451 https://doi.org/10.1038/nature10642
    452 rdf:type schema:CreativeWork
    453 sg:pub.10.1038/nature10860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000103968
    454 https://doi.org/10.1038/nature10860
    455 rdf:type schema:CreativeWork
    456 sg:pub.10.1038/nature10866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010733927
    457 https://doi.org/10.1038/nature10866
    458 rdf:type schema:CreativeWork
    459 sg:pub.10.1038/nature11323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009726441
    460 https://doi.org/10.1038/nature11323
    461 rdf:type schema:CreativeWork
    462 sg:pub.10.1038/ng.890 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006974173
    463 https://doi.org/10.1038/ng.890
    464 rdf:type schema:CreativeWork
    465 sg:pub.10.1038/nm.2453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045398326
    466 https://doi.org/10.1038/nm.2453
    467 rdf:type schema:CreativeWork
    468 sg:pub.10.1038/nrc3038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008995827
    469 https://doi.org/10.1038/nrc3038
    470 rdf:type schema:CreativeWork
    471 sg:pub.10.1038/onc.2009.358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041066726
    472 https://doi.org/10.1038/onc.2009.358
    473 rdf:type schema:CreativeWork
    474 sg:pub.10.1038/sj.onc.1204287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039224613
    475 https://doi.org/10.1038/sj.onc.1204287
    476 rdf:type schema:CreativeWork
    477 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
    478 https://app.dimensions.ai/details/publication/pub.1078048625 schema:CreativeWork
    479 https://app.dimensions.ai/details/publication/pub.1080137536 schema:CreativeWork
    480 https://app.dimensions.ai/details/publication/pub.1081444389 schema:CreativeWork
    481 https://app.dimensions.ai/details/publication/pub.1082783475 schema:CreativeWork
    482 https://doi.org/10.1002/ajmg.c.30086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001481352
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1002/ijc.25448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043120298
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1002/pmic.200800902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016008729
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1016/0167-4889(90)90240-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1045028731
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1016/j.ccr.2009.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009110560
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1016/j.ccr.2010.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040778422
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1016/j.ccr.2010.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010196923
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1016/j.ccr.2010.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044538954
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1016/j.ccr.2012.08.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052838309
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1016/j.cmet.2007.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035229222
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1016/j.molmed.2010.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016375042
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1042/bj20061506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011999534
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1046/j.1471-4159.1998.71020863.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026252307
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1046/j.1471-4159.2001.00156.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007949438
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1056/nejmoa0808710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035319148
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1073/pnas.0507816102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009416951
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1073/pnas.0709747104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016350654
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1073/pnas.0810199105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007462431
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1073/pnas.1019393108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017876854
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1073/pnas.1117773108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043292855
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1074/jbc.273.9.4982 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014217323
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1074/jbc.m506486200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007342499
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1093/ajcn/68.1.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083291431
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1093/bioinformatics/btq113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024016716
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1093/jn/135.6.1557s schema:sameAs https://app.dimensions.ai/details/publication/pub.1077060426
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1093/jnci/djq187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010611295
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1093/neuonc/nop007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039320053
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1093/oxfordjournals.jbchem.a128277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081458377
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1101/gad.198200.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033943545
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1111/j.1471-4159.2006.03813.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044780690
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1111/j.1471-4159.2006.04332.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021664720
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1111/j.1471-4159.2008.05301.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045581833
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1126/science.1164382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048029720
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1126/science.1170944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025009423
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1126/science.1218595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025191587
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1126/science.122.3168.501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062466253
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1152/ajpendo.00276.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029800022
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1158/0008-5472.can-09-2266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023081409
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1158/0008-5472.can-09-2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040629839
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1158/0008-5472.can-10-1666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051110747
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1158/1078-0432.ccr-09-1800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031254541
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1215/15228517-2008-032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044393210
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.1215/15228517-2009-025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043122141
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.1371/journal.pone.0007752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018946723
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.1371/journal.pone.0008726 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019426788
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.3727/000000007783980873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077532388
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.3748/wjg.v12.i36.5884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071365023
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.4161/cc.8.3.7701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300547
    577 rdf:type schema:CreativeWork
    578 https://www.grid.ac/institutes/grid.255649.9 schema:alternateName Ewha Womans University
    579 schema:name Department of Nutritional Science and Food Management, College of Health Science, Ewha Womans University, Seoul, South Korea.
    580 Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
    581 rdf:type schema:Organization
    582 https://www.grid.ac/institutes/grid.411327.2 schema:alternateName Heinrich Heine University Düsseldorf
    583 schema:name Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
    584 rdf:type schema:Organization
    585 https://www.grid.ac/institutes/grid.419534.e schema:alternateName Max Planck Institute for Intelligent Systems
    586 schema:name Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.
    587 rdf:type schema:Organization
    588 https://www.grid.ac/institutes/grid.434088.3 schema:alternateName Reutlingen University
    589 schema:name Department of New Materials and Biosystems, Max Planck Institute for Intelligent Systems, Stuttgart, Germany.
    590 Reutlingen University of Applied Science, Reutlingen, Germany.
    591 rdf:type schema:Organization
    592 https://www.grid.ac/institutes/grid.438526.e schema:alternateName Virginia Tech
    593 schema:name Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute, Blacksburg, Virginia, USA.
    594 rdf:type schema:Organization
    595 https://www.grid.ac/institutes/grid.51462.34 schema:alternateName Memorial Sloan Kettering Cancer Center
    596 schema:name Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
    597 rdf:type schema:Organization
    598 https://www.grid.ac/institutes/grid.5253.1 schema:alternateName University Hospital Heidelberg
    599 schema:name Department of General Pediatrics, Division of Inborn Metabolic Diseases, University Children's Hospital, Heidelberg, Germany.
    600 Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
    601 Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    602 Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.
    603 rdf:type schema:Organization
    604 https://www.grid.ac/institutes/grid.7497.d schema:alternateName German Cancer Research Center
    605 schema:name Clinical Cooperation Unit Neurooncology, DKFZ, Heidelberg, Germany.
    606 Core Facility, Molecular Structural Analysis, DKFZ, Heidelberg, Germany.
    607 Core Facility, Small Animal Imaging Center, DKFZ, Heidelberg, Germany.
    608 Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology and Bioquant, University of Heidelberg, Heidelberg, Germany.
    609 Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
    610 Division of Epigenomics and Cancer Risk Factors, DKFZ, Heidelberg, Germany.
    611 Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    612 Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany.
    613 Division of Theoretical Bioinformatics, DKFZ, Heidelberg, Germany.
    614 German Cancer Consortium (DKTK), DKFZ, Heidelberg, Germany.
    615 rdf:type schema:Organization
    616 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
    617 schema:name Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany.
    618 Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany.
    619 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...