Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Nicola Gagliani, Chiara F Magnani, Samuel Huber, Monica E Gianolini, Mauro Pala, Paula Licona-Limon, Binggege Guo, De'Broski R Herbert, Alessandro Bulfone, Filippo Trentini, Clelia Di Serio, Rosa Bacchetta, Marco Andreani, Leonie Brockmann, Silvia Gregori, Richard A Flavell, Maria-Grazia Roncarolo

ABSTRACT

CD4(+) type 1 T regulatory (Tr1) cells are induced in the periphery and have a pivotal role in promoting and maintaining tolerance. The absence of surface markers that uniquely identify Tr1 cells has limited their study and clinical applications. By gene expression profiling of human Tr1 cell clones, we identified the surface markers CD49b and lymphocyte activation gene 3 (LAG-3) as being stably and selectively coexpressed on mouse and human Tr1 cells. We showed the specificity of these markers in mouse models of intestinal inflammation and helminth infection and in the peripheral blood of healthy volunteers. The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation. The use of these markers makes it feasible to track Tr1 cells in vivo and purify Tr1 cells for cell therapy to induce or restore tolerance in subjects with immune-mediated diseases. More... »

PAGES

739

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.3179

DOI

http://dx.doi.org/10.1038/nm.3179

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053642413

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23624599


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