A colorectal cancer classification system that associates cellular phenotype and responses to therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04-14

AUTHORS

Anguraj Sadanandam, Costas A Lyssiotis, Krisztian Homicsko, Eric A Collisson, William J Gibb, Stephan Wullschleger, Liliane C Gonzalez Ostos, William A Lannon, Carsten Grotzinger, Maguy Del Rio, Benoit Lhermitte, Adam B Olshen, Bertram Wiedenmann, Lewis C Cantley, Joe W Gray, Douglas Hanahan

ABSTRACT

Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor-targeted drug cetuximab in 80 patients. The results of these studies define six clinically relevant CRC subtypes. Each subtype shares similarities to distinct cell types within the normal colon crypt and shows differing degrees of 'stemness' and Wnt signaling. Subtype-specific gene signatures are proposed to identify these subtypes. Three subtypes have markedly better disease-free survival (DFS) after surgical resection, suggesting these patients might be spared from the adverse effects of chemotherapy when they have localized disease. One of these three subtypes, identified by filamin A expression, does not respond to cetuximab but may respond to cMET receptor tyrosine kinase inhibitors in the metastatic setting. Two other subtypes, with poor and intermediate DFS, associate with improved response to the chemotherapy regimen FOLFIRI in adjuvant or metastatic settings. Development of clinically deployable assays for these subtypes and of subtype-specific therapies may contribute to more effective management of this challenging disease. More... »

PAGES

619-625

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.3175

DOI

http://dx.doi.org/10.1038/nm.3175

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031452671

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23584089


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal, Humanized", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cetuximab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.5333.6", 
          "name": [
            "Swiss Institute of Bioinformatics, Lausanne, Switzerland.", 
            "Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sadanandam", 
        "givenName": "Anguraj", 
        "id": "sg:person.01052433537.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052433537.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.", 
            "Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lyssiotis", 
        "givenName": "Costas A", 
        "id": "sg:person.01326033556.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326033556.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.8515.9", 
          "name": [
            "Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.", 
            "Service of Medical Oncology, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Homicsko", 
        "givenName": "Krisztian", 
        "id": "sg:person.01305063722.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305063722.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Division of Hematology and Oncology, University of California\u2013San Francisco, San Francisco, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Collisson", 
        "givenName": "Eric A", 
        "id": "sg:person.016364317617.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016364317617.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Genomic Health (United States)", 
          "id": "https://www.grid.ac/institutes/grid.467415.5", 
          "name": [
            "Genomic Health, Redwood City, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gibb", 
        "givenName": "William J", 
        "id": "sg:person.0627573022.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627573022.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.5333.6", 
          "name": [
            "Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wullschleger", 
        "givenName": "Stephan", 
        "id": "sg:person.0675706222.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675706222.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.5333.6", 
          "name": [
            "Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ostos", 
        "givenName": "Liliane C Gonzalez", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Beth Israel Deaconess Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.239395.7", 
          "name": [
            "Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lannon", 
        "givenName": "William A", 
        "id": "sg:person.01012134622.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012134622.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Department of Hepatology and Gastroenterology, Charit\u00e9, Campus Virchow-Klinikum, University Medicine Berlin, Berlin, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grotzinger", 
        "givenName": "Carsten", 
        "id": "sg:person.0726415225.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726415225.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institut de Recherche en Canc\u00e9rologie de Montpellier, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U896, Universit\u00e9 Montpellier, Centre R\u00e9gional de Lutte contre le Cancer Val d'Aurelle Paul Lamarque, Montpellier, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Del Rio", 
        "givenName": "Maguy", 
        "id": "sg:person.01077111010.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077111010.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.9851.5", 
          "name": [
            "University Institute of Pathology, CHUV, Lausanne, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lhermitte", 
        "givenName": "Benoit", 
        "id": "sg:person.0703447776.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703447776.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California, San Francisco", 
          "id": "https://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Epidemiology and Biostatistics, University of California\u2013San Francisco, San Francisco, California, USA.", 
            "Helen Diller Comprehensive Cancer Center, University of California\u2013San Francisco, San Francisco, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olshen", 
        "givenName": "Adam B", 
        "id": "sg:person.01154314560.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154314560.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Virchow Klinikum", 
          "id": "https://www.grid.ac/institutes/grid.418434.e", 
          "name": [
            "Department of Hepatology and Gastroenterology, Charit\u00e9, Campus Virchow-Klinikum, University Medicine Berlin, Berlin, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wiedenmann", 
        "givenName": "Bertram", 
        "id": "sg:person.010162355177.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010162355177.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.", 
            "Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cantley", 
        "givenName": "Lewis C", 
        "id": "sg:person.013560615677.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013560615677.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oregon Health & Science University", 
          "id": "https://www.grid.ac/institutes/grid.5288.7", 
          "name": [
            "Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gray", 
        "givenName": "Joe W", 
        "id": "sg:person.014525340267.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525340267.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne", 
          "id": "https://www.grid.ac/institutes/grid.5333.6", 
          "name": [
            "Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hanahan", 
        "givenName": "Douglas", 
        "id": "sg:person.01002110407.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002110407.64"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature10166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000736346", 
          "https://doi.org/10.1038/nature10166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000822037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0308531101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001366510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.091062498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001631710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002290143", 
          "https://doi.org/10.1186/1471-2407-12-260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1018854108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004692269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0959-8049(99)00150-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008635416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2009.12.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009110560"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.051629398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010092611"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010619765", 
          "https://doi.org/10.1038/nature11252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.21.6663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010862676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35000501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898206", 
          "https://doi.org/10.1038/35000501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35000501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010898206", 
          "https://doi.org/10.1038/35000501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.12.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012347371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2344", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017392354", 
          "https://doi.org/10.1038/nm.2344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0707210104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018480428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-3788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021328466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0015543", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023003991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.10.5437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024397161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2006-7-3-r19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026127042", 
          "https://doi.org/10.1186/gb-2006-7-3-r19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25417", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026310472"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029818016", 
          "https://doi.org/10.1038/nbt.2038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.2038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029818016", 
          "https://doi.org/10.1038/nbt.2038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030083091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030083091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35021093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846543", 
          "https://doi.org/10.1038/35021093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa033025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035161767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035200906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036060000", 
          "https://doi.org/10.1038/nature11003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-1431", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036636512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1117029108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037133216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.082099299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037994416"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.07.4187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038214181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041002524", 
          "https://doi.org/10.1038/ncb2048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb2048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041002524", 
          "https://doi.org/10.1038/ncb2048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0377-0427(87)90125-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041584630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btg385", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043809080"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(10)70087-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044058214"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm496", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045547866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1476-4598-3-21", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049362447", 
          "https://doi.org/10.1186/1476-4598-3-21"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049534215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053042364", 
          "https://doi.org/10.1038/nrc2392"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04-14", 
    "datePublishedReg": "2013-04-14", 
    "description": "Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor-targeted drug cetuximab in 80 patients. The results of these studies define six clinically relevant CRC subtypes. Each subtype shares similarities to distinct cell types within the normal colon crypt and shows differing degrees of 'stemness' and Wnt signaling. Subtype-specific gene signatures are proposed to identify these subtypes. Three subtypes have markedly better disease-free survival (DFS) after surgical resection, suggesting these patients might be spared from the adverse effects of chemotherapy when they have localized disease. One of these three subtypes, identified by filamin A expression, does not respond to cetuximab but may respond to cMET receptor tyrosine kinase inhibitors in the metastatic setting. Two other subtypes, with poor and intermediate DFS, associate with improved response to the chemotherapy regimen FOLFIRI in adjuvant or metastatic settings. Development of clinically deployable assays for these subtypes and of subtype-specific therapies may contribute to more effective management of this challenging disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm.3175", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7745425", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2411208", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2699025", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "A colorectal cancer classification system that associates cellular phenotype and responses to therapy", 
    "pagination": "619-625", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "95d578f65bc392650187307ba253f84bb1763fe7a26a90f42b9e5067a0aec808"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23584089"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.3175"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031452671"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.3175", 
      "https://app.dimensions.ai/details/publication/pub.1031452671"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nm.3175"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.3175'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.3175'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.3175'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.3175'


 

This table displays all metadata directly associated to this object as RDF triples.

392 TRIPLES      21 PREDICATES      80 URIs      34 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.3175 schema:about N4fdbee7c3e5a430387ce671cbfb097d2
2 N60b7145ac8674121b1cac20b3c334fb7
3 N6397f9c41e2a466ab46cb73fbc3f3548
4 N643537ace8f1497aad657c6c2e6be9be
5 N72338a3de9214c4a838a170ef658d0bf
6 Na22f38307a6f414cb689c10079652ca9
7 Naa34206650914a96b9337f9e2203f341
8 Nb14653225d8f4c14b1900adc6b0a50cb
9 Nb5dd142d236f4af4a3b2b453a1ebbbcd
10 Nb6913f70a1884acca1dcb6329e98fbfe
11 Nb8e8e1c7c1bb4d0a8daf88700ff2070b
12 Nd5fe3ec744184e92830d8eeeec648b91
13 Nd957493744c1432d9293d4f147db68ef
14 Nfd1913fa23064b1ab3b453be94f479d4
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N1935b62204a44d0d983e6ecfef00aa5b
18 schema:citation sg:pub.10.1038/35000501
19 sg:pub.10.1038/35021093
20 sg:pub.10.1038/nature10166
21 sg:pub.10.1038/nature11003
22 sg:pub.10.1038/nature11252
23 sg:pub.10.1038/nbt.2038
24 sg:pub.10.1038/ncb2048
25 sg:pub.10.1038/nm.2344
26 sg:pub.10.1038/nrc2392
27 sg:pub.10.1186/1471-2407-12-260
28 sg:pub.10.1186/1476-4598-3-21
29 sg:pub.10.1186/gb-2006-7-3-r19
30 https://doi.org/10.1002/ijc.25417
31 https://doi.org/10.1016/0377-0427(87)90125-7
32 https://doi.org/10.1016/j.ccr.2009.12.020
33 https://doi.org/10.1016/j.cell.2012.12.012
34 https://doi.org/10.1016/s0959-8049(99)00150-1
35 https://doi.org/10.1016/s1470-2045(10)70087-5
36 https://doi.org/10.1056/nejmoa033025
37 https://doi.org/10.1073/pnas.0308531101
38 https://doi.org/10.1073/pnas.051629398
39 https://doi.org/10.1073/pnas.0707210104
40 https://doi.org/10.1073/pnas.082099299
41 https://doi.org/10.1073/pnas.091062498
42 https://doi.org/10.1073/pnas.1018854108
43 https://doi.org/10.1073/pnas.1117029108
44 https://doi.org/10.1093/annonc/mdm496
45 https://doi.org/10.1093/annonc/mdp126
46 https://doi.org/10.1093/bioinformatics/btg385
47 https://doi.org/10.1158/0008-5472.can-09-3788
48 https://doi.org/10.1158/1078-0432.ccr-08-0196
49 https://doi.org/10.1158/1078-0432.ccr-08-1431
50 https://doi.org/10.1158/1078-0432.ccr-09-1431
51 https://doi.org/10.1158/1078-0432.ccr-09-1570
52 https://doi.org/10.1200/jco.2006.07.4187
53 https://doi.org/10.1200/jco.2006.10.5437
54 https://doi.org/10.1200/jco.2008.21.6663
55 https://doi.org/10.1371/journal.pone.0015543
56 schema:datePublished 2013-04-14
57 schema:datePublishedReg 2013-04-14
58 schema:description Colorectal cancer (CRC) is a major cause of cancer mortality. Whereas some patients respond well to therapy, others do not, and thus more precise, individualized treatment strategies are needed. To that end, we analyzed gene expression profiles from 1,290 CRC tumors using consensus-based unsupervised clustering. The resultant clusters were then associated with therapeutic response data to the epidermal growth factor receptor-targeted drug cetuximab in 80 patients. The results of these studies define six clinically relevant CRC subtypes. Each subtype shares similarities to distinct cell types within the normal colon crypt and shows differing degrees of 'stemness' and Wnt signaling. Subtype-specific gene signatures are proposed to identify these subtypes. Three subtypes have markedly better disease-free survival (DFS) after surgical resection, suggesting these patients might be spared from the adverse effects of chemotherapy when they have localized disease. One of these three subtypes, identified by filamin A expression, does not respond to cetuximab but may respond to cMET receptor tyrosine kinase inhibitors in the metastatic setting. Two other subtypes, with poor and intermediate DFS, associate with improved response to the chemotherapy regimen FOLFIRI in adjuvant or metastatic settings. Development of clinically deployable assays for these subtypes and of subtype-specific therapies may contribute to more effective management of this challenging disease.
59 schema:genre research_article
60 schema:inLanguage en
61 schema:isAccessibleForFree true
62 schema:isPartOf Nc5446daf098146008ff3b229442f3ffa
63 Nf396ed8b4d9147178a4ee18dd9b6d988
64 sg:journal.1113716
65 schema:name A colorectal cancer classification system that associates cellular phenotype and responses to therapy
66 schema:pagination 619-625
67 schema:productId N299dd5ec406b44099ad0e3937e3ccf3d
68 N652070b9dfba44bea760aba6b0fd5701
69 N7639544e0ca7408d951fce9a7a6f8c5a
70 N77e3ac985971432f97bec04747ca4473
71 N995156e61cd646d1bc7ad64de723d7ef
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031452671
73 https://doi.org/10.1038/nm.3175
74 schema:sdDatePublished 2019-04-10T22:19
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N886c18c67d12429fb1884d2110fdc69c
77 schema:url http://www.nature.com/articles/nm.3175
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N1935b62204a44d0d983e6ecfef00aa5b rdf:first sg:person.01052433537.19
82 rdf:rest N67f54dfd00614d728e8da2d590393f83
83 N299dd5ec406b44099ad0e3937e3ccf3d schema:name readcube_id
84 schema:value 95d578f65bc392650187307ba253f84bb1763fe7a26a90f42b9e5067a0aec808
85 rdf:type schema:PropertyValue
86 N35c30de0c491404c807c03a7abe3b17b rdf:first sg:person.01305063722.20
87 rdf:rest N41b43091572a498e9fe77329e6e9419e
88 N41b43091572a498e9fe77329e6e9419e rdf:first sg:person.016364317617.64
89 rdf:rest N5e94bbb4075d4cd1a1adf2f3e661a0e9
90 N4fdbee7c3e5a430387ce671cbfb097d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Genetic Markers
92 rdf:type schema:DefinedTerm
93 N55543b3392564d20ae51d1c4699afe7b rdf:first sg:person.014525340267.00
94 rdf:rest Nb8e1ee23281242629201cc1ef15c8ab2
95 N57007c25c3774fb599e1988708243b34 rdf:first sg:person.01154314560.39
96 rdf:rest Nd59f03328aae47aa829f987fd42edb48
97 N5e94bbb4075d4cd1a1adf2f3e661a0e9 rdf:first sg:person.0627573022.69
98 rdf:rest Nd0810a0bff5942efa0beb2407befc1fd
99 N60b7145ac8674121b1cac20b3c334fb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Oligonucleotide Array Sequence Analysis
101 rdf:type schema:DefinedTerm
102 N61079aafb3444eb3ac54edea2296e9ea schema:name Institut de Recherche en Cancérologie de Montpellier, Institut National de la Santé et de la Recherche Médicale, U896, Université Montpellier, Centre Régional de Lutte contre le Cancer Val d'Aurelle Paul Lamarque, Montpellier, France.
103 rdf:type schema:Organization
104 N6397f9c41e2a466ab46cb73fbc3f3548 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Phenotype
106 rdf:type schema:DefinedTerm
107 N643537ace8f1497aad657c6c2e6be9be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Humans
109 rdf:type schema:DefinedTerm
110 N652070b9dfba44bea760aba6b0fd5701 schema:name pubmed_id
111 schema:value 23584089
112 rdf:type schema:PropertyValue
113 N67f54dfd00614d728e8da2d590393f83 rdf:first sg:person.01326033556.41
114 rdf:rest N35c30de0c491404c807c03a7abe3b17b
115 N69359ed6ec2542d89770867bb24a84c2 rdf:first sg:person.01012134622.84
116 rdf:rest N725a103978cb4911b52cdb2305b47059
117 N6c5206e35de742d5b4405df9ea4f6edf rdf:first sg:person.013560615677.26
118 rdf:rest N55543b3392564d20ae51d1c4699afe7b
119 N70ac61b1ec2d4e08937c52bcd582e26c rdf:first sg:person.0703447776.87
120 rdf:rest N57007c25c3774fb599e1988708243b34
121 N72338a3de9214c4a838a170ef658d0bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Colon
123 rdf:type schema:DefinedTerm
124 N725a103978cb4911b52cdb2305b47059 rdf:first sg:person.0726415225.77
125 rdf:rest N72a3c2c8f87045c6a83b8069c5e7d74c
126 N72a3c2c8f87045c6a83b8069c5e7d74c rdf:first sg:person.01077111010.61
127 rdf:rest N70ac61b1ec2d4e08937c52bcd582e26c
128 N7639544e0ca7408d951fce9a7a6f8c5a schema:name doi
129 schema:value 10.1038/nm.3175
130 rdf:type schema:PropertyValue
131 N77e3ac985971432f97bec04747ca4473 schema:name dimensions_id
132 schema:value pub.1031452671
133 rdf:type schema:PropertyValue
134 N886c18c67d12429fb1884d2110fdc69c schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 N995156e61cd646d1bc7ad64de723d7ef schema:name nlm_unique_id
137 schema:value 9502015
138 rdf:type schema:PropertyValue
139 Na22f38307a6f414cb689c10079652ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Gene Expression Regulation, Neoplastic
141 rdf:type schema:DefinedTerm
142 Naa34206650914a96b9337f9e2203f341 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Signal Transduction
144 rdf:type schema:DefinedTerm
145 Nab9a01fb1d294ea1852e7cd6c1bcadf4 rdf:first Nef49da0d64144d49923946dd7bda1da8
146 rdf:rest N69359ed6ec2542d89770867bb24a84c2
147 Nb14653225d8f4c14b1900adc6b0a50cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Antineoplastic Agents
149 rdf:type schema:DefinedTerm
150 Nb5dd142d236f4af4a3b2b453a1ebbbcd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Neoplasm Metastasis
152 rdf:type schema:DefinedTerm
153 Nb6913f70a1884acca1dcb6329e98fbfe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Cetuximab
155 rdf:type schema:DefinedTerm
156 Nb8e1ee23281242629201cc1ef15c8ab2 rdf:first sg:person.01002110407.64
157 rdf:rest rdf:nil
158 Nb8e8e1c7c1bb4d0a8daf88700ff2070b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Antibodies, Monoclonal, Humanized
160 rdf:type schema:DefinedTerm
161 Nc5446daf098146008ff3b229442f3ffa schema:volumeNumber 19
162 rdf:type schema:PublicationVolume
163 Nd0810a0bff5942efa0beb2407befc1fd rdf:first sg:person.0675706222.06
164 rdf:rest Nab9a01fb1d294ea1852e7cd6c1bcadf4
165 Nd59f03328aae47aa829f987fd42edb48 rdf:first sg:person.010162355177.30
166 rdf:rest N6c5206e35de742d5b4405df9ea4f6edf
167 Nd5fe3ec744184e92830d8eeeec648b91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Expression Profiling
169 rdf:type schema:DefinedTerm
170 Nd957493744c1432d9293d4f147db68ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Colorectal Neoplasms
172 rdf:type schema:DefinedTerm
173 Nef49da0d64144d49923946dd7bda1da8 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
174 schema:familyName Ostos
175 schema:givenName Liliane C Gonzalez
176 rdf:type schema:Person
177 Nf396ed8b4d9147178a4ee18dd9b6d988 schema:issueNumber 5
178 rdf:type schema:PublicationIssue
179 Nfd1913fa23064b1ab3b453be94f479d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Treatment Outcome
181 rdf:type schema:DefinedTerm
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
186 schema:name Oncology and Carcinogenesis
187 rdf:type schema:DefinedTerm
188 sg:grant.2411208 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3175
189 rdf:type schema:MonetaryGrant
190 sg:grant.2699025 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3175
191 rdf:type schema:MonetaryGrant
192 sg:grant.7745425 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.3175
193 rdf:type schema:MonetaryGrant
194 sg:journal.1113716 schema:issn 1078-8956
195 1546-170X
196 schema:name Nature Medicine
197 rdf:type schema:Periodical
198 sg:person.01002110407.64 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
199 schema:familyName Hanahan
200 schema:givenName Douglas
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002110407.64
202 rdf:type schema:Person
203 sg:person.01012134622.84 schema:affiliation https://www.grid.ac/institutes/grid.239395.7
204 schema:familyName Lannon
205 schema:givenName William A
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012134622.84
207 rdf:type schema:Person
208 sg:person.010162355177.30 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
209 schema:familyName Wiedenmann
210 schema:givenName Bertram
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010162355177.30
212 rdf:type schema:Person
213 sg:person.01052433537.19 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
214 schema:familyName Sadanandam
215 schema:givenName Anguraj
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052433537.19
217 rdf:type schema:Person
218 sg:person.01077111010.61 schema:affiliation N61079aafb3444eb3ac54edea2296e9ea
219 schema:familyName Del Rio
220 schema:givenName Maguy
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077111010.61
222 rdf:type schema:Person
223 sg:person.01154314560.39 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
224 schema:familyName Olshen
225 schema:givenName Adam B
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154314560.39
227 rdf:type schema:Person
228 sg:person.01305063722.20 schema:affiliation https://www.grid.ac/institutes/grid.8515.9
229 schema:familyName Homicsko
230 schema:givenName Krisztian
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305063722.20
232 rdf:type schema:Person
233 sg:person.01326033556.41 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
234 schema:familyName Lyssiotis
235 schema:givenName Costas A
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326033556.41
237 rdf:type schema:Person
238 sg:person.013560615677.26 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
239 schema:familyName Cantley
240 schema:givenName Lewis C
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013560615677.26
242 rdf:type schema:Person
243 sg:person.014525340267.00 schema:affiliation https://www.grid.ac/institutes/grid.5288.7
244 schema:familyName Gray
245 schema:givenName Joe W
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014525340267.00
247 rdf:type schema:Person
248 sg:person.016364317617.64 schema:affiliation https://www.grid.ac/institutes/grid.266102.1
249 schema:familyName Collisson
250 schema:givenName Eric A
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016364317617.64
252 rdf:type schema:Person
253 sg:person.0627573022.69 schema:affiliation https://www.grid.ac/institutes/grid.467415.5
254 schema:familyName Gibb
255 schema:givenName William J
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627573022.69
257 rdf:type schema:Person
258 sg:person.0675706222.06 schema:affiliation https://www.grid.ac/institutes/grid.5333.6
259 schema:familyName Wullschleger
260 schema:givenName Stephan
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675706222.06
262 rdf:type schema:Person
263 sg:person.0703447776.87 schema:affiliation https://www.grid.ac/institutes/grid.9851.5
264 schema:familyName Lhermitte
265 schema:givenName Benoit
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703447776.87
267 rdf:type schema:Person
268 sg:person.0726415225.77 schema:affiliation https://www.grid.ac/institutes/grid.418434.e
269 schema:familyName Grotzinger
270 schema:givenName Carsten
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726415225.77
272 rdf:type schema:Person
273 sg:pub.10.1038/35000501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010898206
274 https://doi.org/10.1038/35000501
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
277 https://doi.org/10.1038/35021093
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nature10166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000736346
280 https://doi.org/10.1038/nature10166
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nature11003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036060000
283 https://doi.org/10.1038/nature11003
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nature11252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010619765
286 https://doi.org/10.1038/nature11252
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nbt.2038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029818016
289 https://doi.org/10.1038/nbt.2038
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/ncb2048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041002524
292 https://doi.org/10.1038/ncb2048
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/nm.2344 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017392354
295 https://doi.org/10.1038/nm.2344
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/nrc2392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053042364
298 https://doi.org/10.1038/nrc2392
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/1471-2407-12-260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002290143
301 https://doi.org/10.1186/1471-2407-12-260
302 rdf:type schema:CreativeWork
303 sg:pub.10.1186/1476-4598-3-21 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049362447
304 https://doi.org/10.1186/1476-4598-3-21
305 rdf:type schema:CreativeWork
306 sg:pub.10.1186/gb-2006-7-3-r19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026127042
307 https://doi.org/10.1186/gb-2006-7-3-r19
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1002/ijc.25417 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026310472
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/0377-0427(87)90125-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041584630
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.ccr.2009.12.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009110560
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.cell.2012.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012347371
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s0959-8049(99)00150-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008635416
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/s1470-2045(10)70087-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044058214
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1056/nejmoa033025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035161767
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1073/pnas.0308531101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001366510
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1073/pnas.051629398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010092611
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1073/pnas.0707210104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018480428
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1073/pnas.082099299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037994416
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1073/pnas.091062498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001631710
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1073/pnas.1018854108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004692269
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1073/pnas.1117029108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037133216
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1093/annonc/mdm496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045547866
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1093/annonc/mdp126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030083091
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1093/bioinformatics/btg385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043809080
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1158/0008-5472.can-09-3788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021328466
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1158/1078-0432.ccr-08-0196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049534215
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1158/1078-0432.ccr-08-1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036636512
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1158/1078-0432.ccr-09-1431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035200906
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1158/1078-0432.ccr-09-1570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000822037
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1200/jco.2006.07.4187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038214181
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1200/jco.2006.10.5437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024397161
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1200/jco.2008.21.6663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010862676
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0015543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023003991
360 rdf:type schema:CreativeWork
361 https://www.grid.ac/institutes/grid.239395.7 schema:alternateName Beth Israel Deaconess Medical Center
362 schema:name Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
363 rdf:type schema:Organization
364 https://www.grid.ac/institutes/grid.266102.1 schema:alternateName University of California, San Francisco
365 schema:name Department of Epidemiology and Biostatistics, University of California–San Francisco, San Francisco, California, USA.
366 Division of Hematology and Oncology, University of California–San Francisco, San Francisco, California, USA.
367 Helen Diller Comprehensive Cancer Center, University of California–San Francisco, San Francisco, California, USA.
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
370 schema:name Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
371 Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.418434.e schema:alternateName Virchow Klinikum
374 schema:name Department of Hepatology and Gastroenterology, Charité, Campus Virchow-Klinikum, University Medicine Berlin, Berlin, Germany.
375 rdf:type schema:Organization
376 https://www.grid.ac/institutes/grid.467415.5 schema:alternateName Genomic Health (United States)
377 schema:name Genomic Health, Redwood City, California, USA.
378 rdf:type schema:Organization
379 https://www.grid.ac/institutes/grid.5288.7 schema:alternateName Oregon Health & Science University
380 schema:name Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon, USA.
381 rdf:type schema:Organization
382 https://www.grid.ac/institutes/grid.5333.6 schema:alternateName École Polytechnique Fédérale de Lausanne
383 schema:name Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
384 Swiss Institute of Bioinformatics, Lausanne, Switzerland.
385 rdf:type schema:Organization
386 https://www.grid.ac/institutes/grid.8515.9 schema:alternateName University Hospital of Lausanne
387 schema:name Service of Medical Oncology, Department of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
388 Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
389 rdf:type schema:Organization
390 https://www.grid.ac/institutes/grid.9851.5 schema:alternateName University of Lausanne
391 schema:name University Institute of Pathology, CHUV, Lausanne, Switzerland.
392 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...