Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04-07

AUTHORS

Robert A Koeth, Zeneng Wang, Bruce S Levison, Jennifer A Buffa, Elin Org, Brendan T Sheehy, Earl B Britt, Xiaoming Fu, Yuping Wu, Lin Li, Jonathan D Smith, Joseph A DiDonato, Jun Chen, Hongzhe Li, Gary D Wu, James D Lewis, Manya Warrier, J Mark Brown, Ronald M Krauss, W H Wilson Tang, Frederic D Bushman, Aldons J Lusis, Stanley L Hazen

ABSTRACT

The long-noted association of red meat with an increased risk of cardiovascular disease may be due to ingestion of a specific compound found in red meat, l-carnitine. The ability of this compound to promote atherosclerosis in mice requires that it be further metabolized by the gut microbiota. In humans, omnivores but not vegans or vegetarians metabolize l-carnitine in this manner, a difference which may be explained by effects of diet on the presence of specific types of bacteria in the gut. More... »

PAGES

576-585

Journal

TITLE

Nature Medicine

ISSUE

5

VOLUME

19

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.3145

    DOI

    http://dx.doi.org/10.1038/nm.3145

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004485531

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23563705


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