ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05-13

AUTHORS

Inbal Avraham-Davidi, Yona Ely, Van N Pham, Daniel Castranova, Moshe Grunspan, Guy Malkinson, Liron Gibbs-Bar, Oded Mayseless, Gabriella Allmog, Brigid Lo, Carmen M Warren, Tom T Chen, Josette Ungos, Kameha Kidd, Kenna Shaw, Ilana Rogachev, Wuzhou Wan, Philip M Murphy, Steven A Farber, Liran Carmel, Gregory S Shelness, M Luisa Iruela-Arispe, Brant M Weinstein, Karina Yaniv

ABSTRACT

High concentrations of some types of plasma lipoproteins, such as low-density lipoprotein, promote atherosclerosis and a wide range of vascular-related diseases. These pathogenic lipoproteins have in common the protein component apolipoprotein B. Through study of the effects of modulating lipoprotein levels in experiments involving zebrafish, mice and cultured human endothelial cells, Inbal Avraham-Davidi et al. uncover a potentially deleterious role of apolipoprotein B–containing lipoproteins as direct inhibitors of the angiogenic behavior of vascular endothelial cells. More... »

PAGES

967-973

Journal

TITLE

Nature Medicine

ISSUE

6

VOLUME

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.2759

DOI

http://dx.doi.org/10.1038/nm.2759

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035300526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22581286


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