Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-05-20

AUTHORS

Takashi Shichita, Eiichi Hasegawa, Akihiro Kimura, Rimpei Morita, Ryota Sakaguchi, Ichiro Takada, Takashi Sekiya, Hiroaki Ooboshi, Takanari Kitazono, Toru Yanagawa, Tetsuro Ishii, Hideo Takahashi, Shuji Mori, Masahiro Nishibori, Kazumichi Kuroda, Shizuo Akira, Kensuke Miyake, Akihiko Yoshimura

ABSTRACT

Brain cells that die after stroke release intracellular proteins into their environment. Akihiko Yoshimura and his colleagues demonstrate that peroxiredoxin proteins released from dying cells induce inflammatory cytokine expression and drive brain damage after stroke.

PAGES

911-917

Journal

TITLE

Nature Medicine

ISSUE

6

VOLUME

18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.2749

DOI

http://dx.doi.org/10.1038/nm.2749

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007752887

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22610280


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Ischemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Encephalitis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HMGB1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-23", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peroxiredoxins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rabbits", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 4", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
            "Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Tokyo, Japan", 
            "Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shichita", 
        "givenName": "Takashi", 
        "id": "sg:person.0610620651.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610620651.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa", 
        "givenName": "Eiichi", 
        "id": "sg:person.01204370040.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204370040.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Akihiro", 
        "id": "sg:person.0636105466.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636105466.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morita", 
        "givenName": "Rimpei", 
        "id": "sg:person.010657364412.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010657364412.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakaguchi", 
        "givenName": "Ryota", 
        "id": "sg:person.01041275651.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041275651.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Ichiro", 
        "id": "sg:person.0631324612.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631324612.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26091.3c", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sekiya", 
        "givenName": "Takashi", 
        "id": "sg:person.01370777172.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370777172.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.418046.f", 
          "name": [
            "Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooboshi", 
        "givenName": "Hiroaki", 
        "id": "sg:person.0765361055.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765361055.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.177174.3", 
          "name": [
            "Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kitazono", 
        "givenName": "Takanari", 
        "id": "sg:person.0720536761.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720536761.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Medicine, University of Tsukuba, Tsukuba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanagawa", 
        "givenName": "Toru", 
        "id": "sg:person.0641614566.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641614566.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Medicine, University of Tsukuba, Tsukuba, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Faculty of Medicine, University of Tsukuba, Tsukuba, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishii", 
        "givenName": "Tetsuro", 
        "id": "sg:person.013222055012.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013222055012.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takahashi", 
        "givenName": "Hideo", 
        "id": "sg:person.015463213204.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015463213204.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mori", 
        "givenName": "Shuji", 
        "id": "sg:person.01314474157.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314474157.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.261356.5", 
          "name": [
            "Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishibori", 
        "givenName": "Masahiro", 
        "id": "sg:person.01043375726.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043375726.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Microbiology, Nihon University School of Medicine, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.260969.2", 
          "name": [
            "Division of Microbiology, Nihon University School of Medicine, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuroda", 
        "givenName": "Kazumichi", 
        "id": "sg:person.01300264457.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300264457.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akira", 
        "givenName": "Shizuo", 
        "id": "sg:person.0731754762.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731754762.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyake", 
        "givenName": "Kensuke", 
        "id": "sg:person.014513702432.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014513702432.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419082.6", 
          "name": [
            "Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan", 
            "Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimura", 
        "givenName": "Akihiko", 
        "id": "sg:person.0702121067.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702121067.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nri2873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007566914", 
          "https://doi.org/10.1038/nri2873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08512", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006302423", 
          "https://doi.org/10.1038/nature08512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsb0598-400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027179789", 
          "https://doi.org/10.1038/nsb0598-400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046174639", 
          "https://doi.org/10.1038/nm1603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2565", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043885234", 
          "https://doi.org/10.1038/nri2565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2226", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000426128", 
          "https://doi.org/10.1038/nm.2226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037388630", 
          "https://doi.org/10.1038/ni.1836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041581353", 
          "https://doi.org/10.1038/nm.2399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007707060", 
          "https://doi.org/10.1038/nm.2507"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature08780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012383431", 
          "https://doi.org/10.1038/nature08780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00018-005-4541-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039894051", 
          "https://doi.org/10.1007/s00018-005-4541-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038047201", 
          "https://doi.org/10.1038/nm.1999"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-05-20", 
    "datePublishedReg": "2012-05-20", 
    "description": "Brain cells that die after stroke release intracellular proteins into their environment. Akihiko Yoshimura and his colleagues demonstrate that peroxiredoxin proteins released from dying cells induce inflammatory cytokine expression and drive brain damage after stroke.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/nm.2749", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6067431", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6079274", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6078008", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6033398", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6086464", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6067169", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6081370", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6072374", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6041371", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6083748", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6006449", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "18"
      }
    ], 
    "keywords": [
      "post-ischemic inflammation", 
      "inflammatory cytokine expression", 
      "cytokine expression", 
      "brain damage", 
      "peroxiredoxin family proteins", 
      "brain cells", 
      "key initiator", 
      "stroke", 
      "intracellular proteins", 
      "cells", 
      "inflammation", 
      "protein", 
      "brain", 
      "family proteins", 
      "expression", 
      "damage", 
      "peroxiredoxin proteins", 
      "colleagues", 
      "initiator", 
      "environment", 
      "Yoshimura"
    ], 
    "name": "Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain", 
    "pagination": "911-917", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1007752887"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.2749"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22610280"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.2749", 
      "https://app.dimensions.ai/details/publication/pub.1007752887"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-08-04T16:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_558.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/nm.2749"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.2749'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.2749'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.2749'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.2749'


 

This table displays all metadata directly associated to this object as RDF triples.

354 TRIPLES      21 PREDICATES      72 URIs      52 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.2749 schema:about N2f7684d630d94e06826857bb9cdf1f78
2 N45695d43b70645f091af24c15e456eb0
3 N472c782fdbfb4b6da5c1eebd2f1b1b4c
4 N5f616d7ae8db4a21a00bb4ca1548569c
5 N6543a216578944eab16e45c5fe4a722c
6 N6632a13694484b33870709e6bc380e49
7 N757cf1f2fda346bd972b18799a7fd281
8 N7c0ce676e08042a8bccb4eaed346c9c0
9 Na27836017d0047d4a2a9fee1ad208a76
10 Nb51db6d9b4bd4ce6a950d6e21387e2a4
11 Nba0a856e5e974e08b3480508823897e6
12 Nc2beff82d819480fb919ea6cd6102053
13 Ncbe0652c8b83428f989ae84d4ee57c1c
14 Ne0b55ce59d0b4d5b8957afe1816de091
15 anzsrc-for:11
16 anzsrc-for:1109
17 schema:author N84c57b70b3914279bbab3e8fb275bad0
18 schema:citation sg:pub.10.1007/s00018-005-4541-5
19 sg:pub.10.1038/nature08512
20 sg:pub.10.1038/nature08780
21 sg:pub.10.1038/ni.1836
22 sg:pub.10.1038/nm.1999
23 sg:pub.10.1038/nm.2226
24 sg:pub.10.1038/nm.2399
25 sg:pub.10.1038/nm.2507
26 sg:pub.10.1038/nm1603
27 sg:pub.10.1038/nri2565
28 sg:pub.10.1038/nri2873
29 sg:pub.10.1038/nsb0598-400
30 schema:datePublished 2012-05-20
31 schema:datePublishedReg 2012-05-20
32 schema:description Brain cells that die after stroke release intracellular proteins into their environment. Akihiko Yoshimura and his colleagues demonstrate that peroxiredoxin proteins released from dying cells induce inflammatory cytokine expression and drive brain damage after stroke.
33 schema:genre article
34 schema:isAccessibleForFree false
35 schema:isPartOf N61107edb06a64e93b1d1fa1a72e585d5
36 Nd3cdc224343f43afa342fe0d14ce3239
37 sg:journal.1113716
38 schema:keywords Yoshimura
39 brain
40 brain cells
41 brain damage
42 cells
43 colleagues
44 cytokine expression
45 damage
46 environment
47 expression
48 family proteins
49 inflammation
50 inflammatory cytokine expression
51 initiator
52 intracellular proteins
53 key initiator
54 peroxiredoxin family proteins
55 peroxiredoxin proteins
56 post-ischemic inflammation
57 protein
58 stroke
59 schema:name Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain
60 schema:pagination 911-917
61 schema:productId N00d13abe94224decaf8bd50f971779dd
62 N8289afc1ef3941ecacbe8d22f334e5ba
63 Nac32508e4c71471fb7fbf5441182d5a8
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007752887
65 https://doi.org/10.1038/nm.2749
66 schema:sdDatePublished 2022-08-04T16:59
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N045147e188274412ad36838d8ddf801e
69 schema:url https://doi.org/10.1038/nm.2749
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N00d13abe94224decaf8bd50f971779dd schema:name dimensions_id
74 schema:value pub.1007752887
75 rdf:type schema:PropertyValue
76 N03ca652d46ca405799b8091e61e35b69 rdf:first sg:person.010657364412.59
77 rdf:rest Na6e22a99fbe3490fae354dc01df96029
78 N0425c73776094042a9a0ed38cfeeca87 rdf:first sg:person.0631324612.21
79 rdf:rest N7d1406c18fdf41dfbdbb472a0d1c41df
80 N045147e188274412ad36838d8ddf801e schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N0a555e77236b4c5c95b673d356dc986d rdf:first sg:person.0731754762.55
83 rdf:rest N84cf7bf167b041909564e340f1c1118b
84 N2f7684d630d94e06826857bb9cdf1f78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Toll-Like Receptor 4
86 rdf:type schema:DefinedTerm
87 N3cfb5b6b00b84db7be75265e935964f1 rdf:first sg:person.0641614566.45
88 rdf:rest N6248c0d4edda4915bad9eb17767e896c
89 N45695d43b70645f091af24c15e456eb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mice
91 rdf:type schema:DefinedTerm
92 N472c782fdbfb4b6da5c1eebd2f1b1b4c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Brain Ischemia
94 rdf:type schema:DefinedTerm
95 N5f616d7ae8db4a21a00bb4ca1548569c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Animals
97 rdf:type schema:DefinedTerm
98 N61107edb06a64e93b1d1fa1a72e585d5 schema:issueNumber 6
99 rdf:type schema:PublicationIssue
100 N6248c0d4edda4915bad9eb17767e896c rdf:first sg:person.013222055012.42
101 rdf:rest Ncd716dcce8814d1fbee47c90c59b4e59
102 N6543a216578944eab16e45c5fe4a722c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Interleukin-23
104 rdf:type schema:DefinedTerm
105 N6632a13694484b33870709e6bc380e49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice, Inbred C57BL
107 rdf:type schema:DefinedTerm
108 N757cf1f2fda346bd972b18799a7fd281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Toll-Like Receptor 2
110 rdf:type schema:DefinedTerm
111 N7c0ce676e08042a8bccb4eaed346c9c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name RNA, Messenger
113 rdf:type schema:DefinedTerm
114 N7d1406c18fdf41dfbdbb472a0d1c41df rdf:first sg:person.01370777172.94
115 rdf:rest Nd961ca1aa83642d2a28bce9b6d604ea5
116 N8289afc1ef3941ecacbe8d22f334e5ba schema:name pubmed_id
117 schema:value 22610280
118 rdf:type schema:PropertyValue
119 N84c57b70b3914279bbab3e8fb275bad0 rdf:first sg:person.0610620651.60
120 rdf:rest N880155344c9746bebe5ac39d826b2a86
121 N84cf7bf167b041909564e340f1c1118b rdf:first sg:person.014513702432.11
122 rdf:rest Na2978e1690954c9084b0299944d4f3c5
123 N880155344c9746bebe5ac39d826b2a86 rdf:first sg:person.01204370040.74
124 rdf:rest Nd4f7a0837fa9406fb94cbe12edb1654b
125 N964e112fcf7c4e67977f1fdc51b62ce8 rdf:first sg:person.01043375726.35
126 rdf:rest N9fe3dd0cbafc44c984b94773736c1176
127 N9fe3dd0cbafc44c984b94773736c1176 rdf:first sg:person.01300264457.40
128 rdf:rest N0a555e77236b4c5c95b673d356dc986d
129 Na27836017d0047d4a2a9fee1ad208a76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Encephalitis
131 rdf:type schema:DefinedTerm
132 Na2978e1690954c9084b0299944d4f3c5 rdf:first sg:person.0702121067.37
133 rdf:rest rdf:nil
134 Na36ac16f9d1b4152be1833aa44501f2f rdf:first sg:person.0720536761.85
135 rdf:rest N3cfb5b6b00b84db7be75265e935964f1
136 Na6e22a99fbe3490fae354dc01df96029 rdf:first sg:person.01041275651.64
137 rdf:rest N0425c73776094042a9a0ed38cfeeca87
138 Nac32508e4c71471fb7fbf5441182d5a8 schema:name doi
139 schema:value 10.1038/nm.2749
140 rdf:type schema:PropertyValue
141 Nb0fbe687dda74b969642c0521ead13f3 rdf:first sg:person.01314474157.39
142 rdf:rest N964e112fcf7c4e67977f1fdc51b62ce8
143 Nb51db6d9b4bd4ce6a950d6e21387e2a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Brain
145 rdf:type schema:DefinedTerm
146 Nba0a856e5e974e08b3480508823897e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Male
148 rdf:type schema:DefinedTerm
149 Nc2beff82d819480fb919ea6cd6102053 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name HMGB1 Protein
151 rdf:type schema:DefinedTerm
152 Ncbe0652c8b83428f989ae84d4ee57c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Rabbits
154 rdf:type schema:DefinedTerm
155 Ncd716dcce8814d1fbee47c90c59b4e59 rdf:first sg:person.015463213204.06
156 rdf:rest Nb0fbe687dda74b969642c0521ead13f3
157 Nd3cdc224343f43afa342fe0d14ce3239 schema:volumeNumber 18
158 rdf:type schema:PublicationVolume
159 Nd4f7a0837fa9406fb94cbe12edb1654b rdf:first sg:person.0636105466.68
160 rdf:rest N03ca652d46ca405799b8091e61e35b69
161 Nd961ca1aa83642d2a28bce9b6d604ea5 rdf:first sg:person.0765361055.07
162 rdf:rest Na36ac16f9d1b4152be1833aa44501f2f
163 Ne0b55ce59d0b4d5b8957afe1816de091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Peroxiredoxins
165 rdf:type schema:DefinedTerm
166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
167 schema:name Medical and Health Sciences
168 rdf:type schema:DefinedTerm
169 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
170 schema:name Neurosciences
171 rdf:type schema:DefinedTerm
172 sg:grant.6006449 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
173 rdf:type schema:MonetaryGrant
174 sg:grant.6033398 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
175 rdf:type schema:MonetaryGrant
176 sg:grant.6041371 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
177 rdf:type schema:MonetaryGrant
178 sg:grant.6067169 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
179 rdf:type schema:MonetaryGrant
180 sg:grant.6067431 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
181 rdf:type schema:MonetaryGrant
182 sg:grant.6072374 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
183 rdf:type schema:MonetaryGrant
184 sg:grant.6078008 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
185 rdf:type schema:MonetaryGrant
186 sg:grant.6079274 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
187 rdf:type schema:MonetaryGrant
188 sg:grant.6081370 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
189 rdf:type schema:MonetaryGrant
190 sg:grant.6083748 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
191 rdf:type schema:MonetaryGrant
192 sg:grant.6086464 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2749
193 rdf:type schema:MonetaryGrant
194 sg:journal.1113716 schema:issn 1078-8956
195 1546-170X
196 schema:name Nature Medicine
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01041275651.64 schema:affiliation grid-institutes:grid.26091.3c
200 schema:familyName Sakaguchi
201 schema:givenName Ryota
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041275651.64
203 rdf:type schema:Person
204 sg:person.01043375726.35 schema:affiliation grid-institutes:grid.261356.5
205 schema:familyName Nishibori
206 schema:givenName Masahiro
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043375726.35
208 rdf:type schema:Person
209 sg:person.010657364412.59 schema:affiliation grid-institutes:grid.26091.3c
210 schema:familyName Morita
211 schema:givenName Rimpei
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010657364412.59
213 rdf:type schema:Person
214 sg:person.01204370040.74 schema:affiliation grid-institutes:grid.26091.3c
215 schema:familyName Hasegawa
216 schema:givenName Eiichi
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01204370040.74
218 rdf:type schema:Person
219 sg:person.01300264457.40 schema:affiliation grid-institutes:grid.260969.2
220 schema:familyName Kuroda
221 schema:givenName Kazumichi
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300264457.40
223 rdf:type schema:Person
224 sg:person.01314474157.39 schema:affiliation grid-institutes:grid.261356.5
225 schema:familyName Mori
226 schema:givenName Shuji
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314474157.39
228 rdf:type schema:Person
229 sg:person.013222055012.42 schema:affiliation grid-institutes:grid.20515.33
230 schema:familyName Ishii
231 schema:givenName Tetsuro
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013222055012.42
233 rdf:type schema:Person
234 sg:person.01370777172.94 schema:affiliation grid-institutes:grid.26091.3c
235 schema:familyName Sekiya
236 schema:givenName Takashi
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370777172.94
238 rdf:type schema:Person
239 sg:person.014513702432.11 schema:affiliation grid-institutes:grid.26999.3d
240 schema:familyName Miyake
241 schema:givenName Kensuke
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014513702432.11
243 rdf:type schema:Person
244 sg:person.015463213204.06 schema:affiliation grid-institutes:grid.261356.5
245 schema:familyName Takahashi
246 schema:givenName Hideo
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015463213204.06
248 rdf:type schema:Person
249 sg:person.0610620651.60 schema:affiliation grid-institutes:grid.177174.3
250 schema:familyName Shichita
251 schema:givenName Takashi
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0610620651.60
253 rdf:type schema:Person
254 sg:person.0631324612.21 schema:affiliation grid-institutes:grid.26091.3c
255 schema:familyName Takada
256 schema:givenName Ichiro
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631324612.21
258 rdf:type schema:Person
259 sg:person.0636105466.68 schema:affiliation grid-institutes:grid.26091.3c
260 schema:familyName Kimura
261 schema:givenName Akihiro
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636105466.68
263 rdf:type schema:Person
264 sg:person.0641614566.45 schema:affiliation grid-institutes:grid.20515.33
265 schema:familyName Yanagawa
266 schema:givenName Toru
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641614566.45
268 rdf:type schema:Person
269 sg:person.0702121067.37 schema:affiliation grid-institutes:grid.419082.6
270 schema:familyName Yoshimura
271 schema:givenName Akihiko
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0702121067.37
273 rdf:type schema:Person
274 sg:person.0720536761.85 schema:affiliation grid-institutes:grid.177174.3
275 schema:familyName Kitazono
276 schema:givenName Takanari
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720536761.85
278 rdf:type schema:Person
279 sg:person.0731754762.55 schema:affiliation grid-institutes:grid.136593.b
280 schema:familyName Akira
281 schema:givenName Shizuo
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731754762.55
283 rdf:type schema:Person
284 sg:person.0765361055.07 schema:affiliation grid-institutes:grid.418046.f
285 schema:familyName Ooboshi
286 schema:givenName Hiroaki
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765361055.07
288 rdf:type schema:Person
289 sg:pub.10.1007/s00018-005-4541-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039894051
290 https://doi.org/10.1007/s00018-005-4541-5
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nature08512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006302423
293 https://doi.org/10.1038/nature08512
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nature08780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012383431
296 https://doi.org/10.1038/nature08780
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/ni.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037388630
299 https://doi.org/10.1038/ni.1836
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/nm.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038047201
302 https://doi.org/10.1038/nm.1999
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nm.2226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000426128
305 https://doi.org/10.1038/nm.2226
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nm.2399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041581353
308 https://doi.org/10.1038/nm.2399
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nm.2507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007707060
311 https://doi.org/10.1038/nm.2507
312 rdf:type schema:CreativeWork
313 sg:pub.10.1038/nm1603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046174639
314 https://doi.org/10.1038/nm1603
315 rdf:type schema:CreativeWork
316 sg:pub.10.1038/nri2565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043885234
317 https://doi.org/10.1038/nri2565
318 rdf:type schema:CreativeWork
319 sg:pub.10.1038/nri2873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007566914
320 https://doi.org/10.1038/nri2873
321 rdf:type schema:CreativeWork
322 sg:pub.10.1038/nsb0598-400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027179789
323 https://doi.org/10.1038/nsb0598-400
324 rdf:type schema:CreativeWork
325 grid-institutes:grid.136593.b schema:alternateName Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
326 schema:name Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
327 rdf:type schema:Organization
328 grid-institutes:grid.177174.3 schema:alternateName Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
329 schema:name Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
330 Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
331 Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Tokyo, Japan
332 rdf:type schema:Organization
333 grid-institutes:grid.20515.33 schema:alternateName Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
334 schema:name Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
335 rdf:type schema:Organization
336 grid-institutes:grid.26091.3c schema:alternateName Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
337 schema:name Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
338 rdf:type schema:Organization
339 grid-institutes:grid.260969.2 schema:alternateName Division of Microbiology, Nihon University School of Medicine, Tokyo, Japan
340 schema:name Division of Microbiology, Nihon University School of Medicine, Tokyo, Japan
341 rdf:type schema:Organization
342 grid-institutes:grid.261356.5 schema:alternateName Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan
343 schema:name Department of Pharmacology, Okayama University Graduate School of Medicine, Okayama, Japan
344 rdf:type schema:Organization
345 grid-institutes:grid.26999.3d schema:alternateName Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
346 schema:name Division of Infectious Genetics, Institute of Medical Science, University of Tokyo, Tokyo, Japan
347 rdf:type schema:Organization
348 grid-institutes:grid.418046.f schema:alternateName Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan
349 schema:name Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Fukuoka, Japan
350 rdf:type schema:Organization
351 grid-institutes:grid.419082.6 schema:alternateName Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan
352 schema:name Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan
353 Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
354 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...