Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-08

AUTHORS

Yeonseok Chung, Shinya Tanaka, Fuliang Chu, Roza I Nurieva, Gustavo J Martinez, Seema Rawal, Yi-Hong Wang, Hoyong Lim, Joseph M Reynolds, Xiao-hui Zhou, Hui-min Fan, Zhong-ming Liu, Sattva S Neelapu, Chen Dong

ABSTRACT

Foxp3(+) regulatory T (T(reg)) cells suppress different types of immune responses to help maintain homeostasis in the body. How T(reg) cells regulate humoral immunity, including germinal center reactions, is unclear. Here we identify a subset of T(reg) cells expressing CXCR5 and Bcl-6 that localize to the germinal centers in mice and humans. The expression of CXCR5 on T(reg) cells depends on Bcl-6. These CXCR5(+)Bcl-6(+) T(reg) cells are absent in the thymus but can be generated de novo from CXCR5(-)Foxp3(+) natural T(reg) precursors. A lack of CXCR5(+) T(reg) cells leads to greater germinal center reactions including germinal center B cells, affinity maturation of antibodies and the differentiation of plasma cells. These results unveil a Bcl-6-CXCR5 axis in T(reg) cells that drives the development of follicular regulatory T (T(FR)) cells that function to inhibit the germinal center reactions. More... »

PAGES

983

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.2426

DOI

http://dx.doi.org/10.1038/nm.2426

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042197765

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21785430


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