B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-05

AUTHORS

Daniel A Winer, Shawn Winer, Lei Shen, Persis P Wadia, Jason Yantha, Geoffrey Paltser, Hubert Tsui, Ping Wu, Matthew G Davidson, Michael N Alonso, Hwei X Leong, Alec Glassford, Maria Caimol, Justin A Kenkel, Thomas F Tedder, Tracey McLaughlin, David B Miklos, H-Michael Dosch, Edgar G Engleman

ABSTRACT

Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance. Here we show a fundamental pathogenic role for B cells in the development of these metabolic abnormalities. B cells accumulate in VAT in diet-induced obese (DIO) mice, and DIO mice lacking B cells are protected from disease despite weight gain. B cell effects on glucose metabolism are mechanistically linked to the activation of proinflammatory macrophages and T cells and to the production of pathogenic IgG antibodies. Treatment with a B cell-depleting CD20 antibody attenuates disease, whereas transfer of IgG from DIO mice rapidly induces insulin resistance and glucose intolerance. Moreover, insulin resistance in obese humans is associated with a unique profile of IgG autoantibodies. These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease. More... »

PAGES

610

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.2353

DOI

http://dx.doi.org/10.1038/nm.2353

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030246788

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21499269


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmunity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Fats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin mu-Chains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intra-Abdominal Fat", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Depletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA.", 
            "Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winer", 
        "givenName": "Daniel A", 
        "id": "sg:person.01143773222.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143773222.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.", 
            "Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Winer", 
        "givenName": "Shawn", 
        "id": "sg:person.0655032722.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655032722.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Lei", 
        "id": "sg:person.01341002376.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341002376.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Medicine, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wadia", 
        "givenName": "Persis P", 
        "id": "sg:person.0760172055.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760172055.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yantha", 
        "givenName": "Jason", 
        "id": "sg:person.01276656207.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276656207.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paltser", 
        "givenName": "Geoffrey", 
        "id": "sg:person.0624674775.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624674775.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tsui", 
        "givenName": "Hubert", 
        "id": "sg:person.0647511412.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647511412.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Ping", 
        "id": "sg:person.01254454713.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254454713.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davidson", 
        "givenName": "Matthew G", 
        "id": "sg:person.01016332650.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016332650.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso", 
        "givenName": "Michael N", 
        "id": "sg:person.01064446050.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064446050.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Leong", 
        "givenName": "Hwei X", 
        "id": "sg:person.01230415076.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230415076.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Endocrinology, Stanford University School of Medicine, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Glassford", 
        "givenName": "Alec", 
        "id": "sg:person.01276530276.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276530276.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caimol", 
        "givenName": "Maria", 
        "id": "sg:person.01344643476.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344643476.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kenkel", 
        "givenName": "Justin A", 
        "id": "sg:person.01247007650.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247007650.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Duke University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.189509.c", 
          "name": [
            "Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tedder", 
        "givenName": "Thomas F", 
        "id": "sg:person.01320663720.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320663720.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stanford University", 
          "id": "https://www.grid.ac/institutes/grid.168010.e", 
          "name": [
            "Division of Endocrinology, Stanford University School of Medicine, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "McLaughlin", 
        "givenName": "Tracey", 
        "id": "sg:person.013250030337.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013250030337.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Medicine, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miklos", 
        "givenName": "David B", 
        "id": "sg:person.01137616010.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137616010.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Toronto", 
          "id": "https://www.grid.ac/institutes/grid.17063.33", 
          "name": [
            "Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dosch", 
        "givenName": "H-Michael", 
        "id": "sg:person.01111351022.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111351022.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Lucile Packard Children's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.414123.1", 
          "name": [
            "Department of Pathology, Stanford University, Palo Alto, California, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Engleman", 
        "givenName": "Edgar G", 
        "id": "sg:person.01274127110.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274127110.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci36030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000380837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35053000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000422653", 
          "https://doi.org/10.1038/35053000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35053000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000422653", 
          "https://doi.org/10.1038/35053000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0709205105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000626748"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-010-1730-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000967259", 
          "https://doi.org/10.1007/s00125-010-1730-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-010-1730-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000967259", 
          "https://doi.org/10.1007/s00125-010-1730-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-010-1730-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000967259", 
          "https://doi.org/10.1007/s00125-010-1730-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001252705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci38388", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001252705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003810856", 
          "https://doi.org/10.1038/nm.2001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003810856", 
          "https://doi.org/10.1038/nm.2001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.074252", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003975297"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005072972", 
          "https://doi.org/10.1038/nri2206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006257367", 
          "https://doi.org/10.1038/nm.1961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1961", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006257367", 
          "https://doi.org/10.1038/nm.1961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci29881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006797069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1000021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007779929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2009.02911.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009070382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1464-5491.2009.02911.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009070382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.2.336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012873980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80191-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015811014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018401818", 
          "https://doi.org/10.1038/nm.1964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.1964", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018401818", 
          "https://doi.org/10.1038/nm.1964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/350423a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018596250", 
          "https://doi.org/10.1038/350423a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0903009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020381423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.1.361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020390569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-physiol-021909-135846", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020792537"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20100155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021025743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.05.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021566716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1194/jlr.m500294-jlr200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025855230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0908771107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027128137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.05.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028045635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.05.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028045635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2008.08.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030994919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db09-0323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032084369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-02-078071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035190574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2010.02.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038658162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-1759(98)00015-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040286227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db07-0767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044551823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2008.00646.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044885138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047056251", 
          "https://doi.org/10.1038/nm.2002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047056251", 
          "https://doi.org/10.1038/nm.2002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7819-4-89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050525124", 
          "https://doi.org/10.1186/1477-7819-4-89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0904130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050674315"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db06-1076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050697274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.177105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052378051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.108.177105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052378051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jhep.2007.12.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053058293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1061620", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7678183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062648363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci19246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci19451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416401"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2008-2354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064291075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.85.1.309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064301029"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-05", 
    "datePublishedReg": "2011-05-01", 
    "description": "Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance. Here we show a fundamental pathogenic role for B cells in the development of these metabolic abnormalities. B cells accumulate in VAT in diet-induced obese (DIO) mice, and DIO mice lacking B cells are protected from disease despite weight gain. B cell effects on glucose metabolism are mechanistically linked to the activation of proinflammatory macrophages and T cells and to the production of pathogenic IgG antibodies. Treatment with a B cell-depleting CD20 antibody attenuates disease, whereas transfer of IgG from DIO mice rapidly induces insulin resistance and glucose intolerance. Moreover, insulin resistance in obese humans is associated with a unique profile of IgG autoantibodies. These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm.2353", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2681813", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2499745", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2499512", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2689133", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "name": "B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies", 
    "pagination": "610", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "90177b85070146ee074aa28ec9a22295dea36ac78c29edd2c5d0505ce5c0c806"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21499269"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.2353"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030246788"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.2353", 
      "https://app.dimensions.ai/details/publication/pub.1030246788"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/nm.2353"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.2353'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.2353'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.2353'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.2353'


 

This table displays all metadata directly associated to this object as RDF triples.

437 TRIPLES      21 PREDICATES      93 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.2353 schema:about N0d9ad57103c54383b628115faee44fa3
2 N11918b40a9e8499dbaaa23285d6247cd
3 N12c344c50bb6423dbf37868758eb5936
4 N15eabbcd8b5b4a6180eba163656a9d86
5 N355d75c7d7cd4b91981979e346c6aba4
6 N3a713df0f98d4e308560ca1cc283d01d
7 N3c2c4cc7e11d463fa5fc4520b63499ad
8 N3c49a8b3ef254746aadd111f29f9ab35
9 N442c52f278384ab58c8db2319ed1e583
10 N62fdc15d2edd41f28b30172905382a2d
11 N8d2da899b0464dec98a23f64ecb308e7
12 N8ef27a6dbec244f4877788fa1f7530f1
13 N9d5f49fc22aa4a62970cff5b6201d273
14 Nb871f880cc5f46ebbd6a8ab62f8dae5f
15 Nb9b231a1ec75499eb4027797a2d6addd
16 Nc0fc5ddbd4d34f2783d45eb3403eca35
17 Ndbb13df1b4d844539e289adddedd5a3c
18 Ned0b100bb95d41ab8ea0212dc696c4d5
19 Nedc3887b91344b199cbec2b904c1c655
20 Nf2dab426a2b34583b4aadf86b0fae1a7
21 Nf671342cc9d14814b60dde8a986d3e28
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author Nc05c604427454e41ba37da875e77cfb1
25 schema:citation sg:pub.10.1007/s00125-010-1730-z
26 sg:pub.10.1038/350423a0
27 sg:pub.10.1038/35053000
28 sg:pub.10.1038/nm.1961
29 sg:pub.10.1038/nm.1964
30 sg:pub.10.1038/nm.2001
31 sg:pub.10.1038/nm.2002
32 sg:pub.10.1038/nri2206
33 sg:pub.10.1186/1477-7819-4-89
34 https://doi.org/10.1016/j.bbrc.2009.05.002
35 https://doi.org/10.1016/j.cell.2010.02.034
36 https://doi.org/10.1016/j.cmet.2008.08.015
37 https://doi.org/10.1016/j.febslet.2005.05.031
38 https://doi.org/10.1016/j.jhep.2007.12.017
39 https://doi.org/10.1016/s0022-1759(98)00015-5
40 https://doi.org/10.1016/s0092-8674(00)80191-9
41 https://doi.org/10.1056/nejmoa0904130
42 https://doi.org/10.1073/pnas.0709205105
43 https://doi.org/10.1073/pnas.0908771107
44 https://doi.org/10.1074/jbc.m109.074252
45 https://doi.org/10.1084/jem.20100155
46 https://doi.org/10.1111/j.1464-5491.2009.02911.x
47 https://doi.org/10.1111/j.1600-065x.2008.00646.x
48 https://doi.org/10.1126/science.1061620
49 https://doi.org/10.1126/science.7678183
50 https://doi.org/10.1146/annurev-physiol-021909-135846
51 https://doi.org/10.1161/circresaha.108.177105
52 https://doi.org/10.1172/jci19246
53 https://doi.org/10.1172/jci19451
54 https://doi.org/10.1172/jci29881
55 https://doi.org/10.1172/jci36030
56 https://doi.org/10.1172/jci38388
57 https://doi.org/10.1182/blood-2008-02-078071
58 https://doi.org/10.1194/jlr.m500294-jlr200
59 https://doi.org/10.1210/jc.2008-2354
60 https://doi.org/10.1210/jc.85.1.309
61 https://doi.org/10.2337/db06-1076
62 https://doi.org/10.2337/db07-0767
63 https://doi.org/10.2337/db09-0323
64 https://doi.org/10.2337/diabetes.53.2.336
65 https://doi.org/10.4049/jimmunol.0903009
66 https://doi.org/10.4049/jimmunol.1000021
67 https://doi.org/10.4049/jimmunol.180.1.361
68 schema:datePublished 2011-05
69 schema:datePublishedReg 2011-05-01
70 schema:description Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance. Here we show a fundamental pathogenic role for B cells in the development of these metabolic abnormalities. B cells accumulate in VAT in diet-induced obese (DIO) mice, and DIO mice lacking B cells are protected from disease despite weight gain. B cell effects on glucose metabolism are mechanistically linked to the activation of proinflammatory macrophages and T cells and to the production of pathogenic IgG antibodies. Treatment with a B cell-depleting CD20 antibody attenuates disease, whereas transfer of IgG from DIO mice rapidly induces insulin resistance and glucose intolerance. Moreover, insulin resistance in obese humans is associated with a unique profile of IgG autoantibodies. These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N96e4b3c41da1456b8e0f9ceed53eca7f
75 Ne1e5ade3fb454777b334f7ef03fe399f
76 sg:journal.1113716
77 schema:name B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
78 schema:pagination 610
79 schema:productId N1d8ce5bee09840d28c16007a9a616120
80 N66e12976204548e8ab26c7ba427b311a
81 N8776403c82d14218bd14454c621a8620
82 N88d3df68866b4d808e88864551d093d9
83 Na7b693020a2f4908a60a5a17ba4224f7
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030246788
85 https://doi.org/10.1038/nm.2353
86 schema:sdDatePublished 2019-04-10T14:49
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher N4720f8326ca84ff4b14c79d4e9d8fdf0
89 schema:url https://www.nature.com/articles/nm.2353
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N05f2f8add91d4656b2b2f604cc6e6a1d rdf:first sg:person.01320663720.49
94 rdf:rest Nf956c5ff0441409990db5773e5f5d5ff
95 N0d9ad57103c54383b628115faee44fa3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name T-Lymphocytes
97 rdf:type schema:DefinedTerm
98 N11918b40a9e8499dbaaa23285d6247cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N12c344c50bb6423dbf37868758eb5936 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mice, Knockout
103 rdf:type schema:DefinedTerm
104 N15eabbcd8b5b4a6180eba163656a9d86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Insulin Resistance
106 rdf:type schema:DefinedTerm
107 N1d8ce5bee09840d28c16007a9a616120 schema:name doi
108 schema:value 10.1038/nm.2353
109 rdf:type schema:PropertyValue
110 N219d478dd7434ee5b0a040144fbef00f rdf:first sg:person.0624674775.82
111 rdf:rest N43bce277f4564791a02f64afbe81d61e
112 N332ee885f79a4c7a87a9248be66325da rdf:first sg:person.01276656207.46
113 rdf:rest N219d478dd7434ee5b0a040144fbef00f
114 N355d75c7d7cd4b91981979e346c6aba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Lymphocyte Depletion
116 rdf:type schema:DefinedTerm
117 N3a713df0f98d4e308560ca1cc283d01d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Glucose
119 rdf:type schema:DefinedTerm
120 N3c2c4cc7e11d463fa5fc4520b63499ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Immunoglobulin G
122 rdf:type schema:DefinedTerm
123 N3c49a8b3ef254746aadd111f29f9ab35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Autoimmunity
125 rdf:type schema:DefinedTerm
126 N43bce277f4564791a02f64afbe81d61e rdf:first sg:person.0647511412.22
127 rdf:rest Nc2a3c2dc01004d27873537d136ec18bd
128 N442c52f278384ab58c8db2319ed1e583 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Obesity
130 rdf:type schema:DefinedTerm
131 N4720f8326ca84ff4b14c79d4e9d8fdf0 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N47e64c31f0f74fcaa64ac5c12a6abcf1 rdf:first sg:person.01247007650.98
134 rdf:rest N05f2f8add91d4656b2b2f604cc6e6a1d
135 N4cfe3d21f0974219b82c244d247ca4cd rdf:first sg:person.01111351022.23
136 rdf:rest N801d98f78419400d93a7b1984a3afc4c
137 N62fdc15d2edd41f28b30172905382a2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Lymphocyte Activation
139 rdf:type schema:DefinedTerm
140 N66e12976204548e8ab26c7ba427b311a schema:name nlm_unique_id
141 schema:value 9502015
142 rdf:type schema:PropertyValue
143 N801d98f78419400d93a7b1984a3afc4c rdf:first sg:person.01274127110.52
144 rdf:rest rdf:nil
145 N826f810b1a28443fb7c3db68e15176ff rdf:first sg:person.01137616010.60
146 rdf:rest N4cfe3d21f0974219b82c244d247ca4cd
147 N84f297d82a134485bca59879d625bed8 rdf:first sg:person.0760172055.71
148 rdf:rest N332ee885f79a4c7a87a9248be66325da
149 N8776403c82d14218bd14454c621a8620 schema:name pubmed_id
150 schema:value 21499269
151 rdf:type schema:PropertyValue
152 N88d3df68866b4d808e88864551d093d9 schema:name readcube_id
153 schema:value 90177b85070146ee074aa28ec9a22295dea36ac78c29edd2c5d0505ce5c0c806
154 rdf:type schema:PropertyValue
155 N8d2da899b0464dec98a23f64ecb308e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Male
157 rdf:type schema:DefinedTerm
158 N8ef27a6dbec244f4877788fa1f7530f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Intra-Abdominal Fat
160 rdf:type schema:DefinedTerm
161 N96e4b3c41da1456b8e0f9ceed53eca7f schema:issueNumber 5
162 rdf:type schema:PublicationIssue
163 N9d5f49fc22aa4a62970cff5b6201d273 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Autoantibodies
165 rdf:type schema:DefinedTerm
166 Na7b693020a2f4908a60a5a17ba4224f7 schema:name dimensions_id
167 schema:value pub.1030246788
168 rdf:type schema:PropertyValue
169 Nac3e2f7c65474e7b8ef1a4da2b7c996a rdf:first sg:person.01341002376.23
170 rdf:rest N84f297d82a134485bca59879d625bed8
171 Nb871f880cc5f46ebbd6a8ab62f8dae5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Inflammation
173 rdf:type schema:DefinedTerm
174 Nb9b231a1ec75499eb4027797a2d6addd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Autoantigens
176 rdf:type schema:DefinedTerm
177 Nbbf8b36c73014ff5aee9aebb32a3f7e8 rdf:first sg:person.01064446050.11
178 rdf:rest Ncc14b188edf34c1889a5a07396a5dad2
179 Nc05c604427454e41ba37da875e77cfb1 rdf:first sg:person.01143773222.31
180 rdf:rest Necda6fa06d59465cb24022142285d4c4
181 Nc0fc5ddbd4d34f2783d45eb3403eca35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Immunoglobulin mu-Chains
183 rdf:type schema:DefinedTerm
184 Nc2a3c2dc01004d27873537d136ec18bd rdf:first sg:person.01254454713.44
185 rdf:rest Ne7907e2049b642df97bf3a95e888d87f
186 Ncc14b188edf34c1889a5a07396a5dad2 rdf:first sg:person.01230415076.44
187 rdf:rest Nf1947ef200aa46e78f5469e58e4fc472
188 Ndbb13df1b4d844539e289adddedd5a3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Mice
190 rdf:type schema:DefinedTerm
191 Ne1e5ade3fb454777b334f7ef03fe399f schema:volumeNumber 17
192 rdf:type schema:PublicationVolume
193 Ne7907e2049b642df97bf3a95e888d87f rdf:first sg:person.01016332650.31
194 rdf:rest Nbbf8b36c73014ff5aee9aebb32a3f7e8
195 Necda6fa06d59465cb24022142285d4c4 rdf:first sg:person.0655032722.01
196 rdf:rest Nac3e2f7c65474e7b8ef1a4da2b7c996a
197 Ned0b100bb95d41ab8ea0212dc696c4d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name B-Lymphocytes
199 rdf:type schema:DefinedTerm
200 Nedc3887b91344b199cbec2b904c1c655 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Mice, Inbred C57BL
202 rdf:type schema:DefinedTerm
203 Nf1947ef200aa46e78f5469e58e4fc472 rdf:first sg:person.01276530276.51
204 rdf:rest Nf973fb46d25f42c495597e5e85268bac
205 Nf2dab426a2b34583b4aadf86b0fae1a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Animals
207 rdf:type schema:DefinedTerm
208 Nf671342cc9d14814b60dde8a986d3e28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Dietary Fats
210 rdf:type schema:DefinedTerm
211 Nf956c5ff0441409990db5773e5f5d5ff rdf:first sg:person.013250030337.51
212 rdf:rest N826f810b1a28443fb7c3db68e15176ff
213 Nf973fb46d25f42c495597e5e85268bac rdf:first sg:person.01344643476.36
214 rdf:rest N47e64c31f0f74fcaa64ac5c12a6abcf1
215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
216 schema:name Medical and Health Sciences
217 rdf:type schema:DefinedTerm
218 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
219 schema:name Clinical Sciences
220 rdf:type schema:DefinedTerm
221 sg:grant.2499512 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2353
222 rdf:type schema:MonetaryGrant
223 sg:grant.2499745 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2353
224 rdf:type schema:MonetaryGrant
225 sg:grant.2681813 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2353
226 rdf:type schema:MonetaryGrant
227 sg:grant.2689133 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2353
228 rdf:type schema:MonetaryGrant
229 sg:journal.1113716 schema:issn 1078-8956
230 1546-170X
231 schema:name Nature Medicine
232 rdf:type schema:Periodical
233 sg:person.01016332650.31 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
234 schema:familyName Davidson
235 schema:givenName Matthew G
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016332650.31
237 rdf:type schema:Person
238 sg:person.01064446050.11 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
239 schema:familyName Alonso
240 schema:givenName Michael N
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064446050.11
242 rdf:type schema:Person
243 sg:person.01111351022.23 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
244 schema:familyName Dosch
245 schema:givenName H-Michael
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111351022.23
247 rdf:type schema:Person
248 sg:person.01137616010.60 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
249 schema:familyName Miklos
250 schema:givenName David B
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137616010.60
252 rdf:type schema:Person
253 sg:person.01143773222.31 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
254 schema:familyName Winer
255 schema:givenName Daniel A
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143773222.31
257 rdf:type schema:Person
258 sg:person.01230415076.44 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
259 schema:familyName Leong
260 schema:givenName Hwei X
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230415076.44
262 rdf:type schema:Person
263 sg:person.01247007650.98 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
264 schema:familyName Kenkel
265 schema:givenName Justin A
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247007650.98
267 rdf:type schema:Person
268 sg:person.01254454713.44 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
269 schema:familyName Wu
270 schema:givenName Ping
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254454713.44
272 rdf:type schema:Person
273 sg:person.01274127110.52 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
274 schema:familyName Engleman
275 schema:givenName Edgar G
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274127110.52
277 rdf:type schema:Person
278 sg:person.01276530276.51 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
279 schema:familyName Glassford
280 schema:givenName Alec
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276530276.51
282 rdf:type schema:Person
283 sg:person.01276656207.46 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
284 schema:familyName Yantha
285 schema:givenName Jason
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276656207.46
287 rdf:type schema:Person
288 sg:person.01320663720.49 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
289 schema:familyName Tedder
290 schema:givenName Thomas F
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320663720.49
292 rdf:type schema:Person
293 sg:person.013250030337.51 schema:affiliation https://www.grid.ac/institutes/grid.168010.e
294 schema:familyName McLaughlin
295 schema:givenName Tracey
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013250030337.51
297 rdf:type schema:Person
298 sg:person.01341002376.23 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
299 schema:familyName Shen
300 schema:givenName Lei
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341002376.23
302 rdf:type schema:Person
303 sg:person.01344643476.36 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
304 schema:familyName Caimol
305 schema:givenName Maria
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344643476.36
307 rdf:type schema:Person
308 sg:person.0624674775.82 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
309 schema:familyName Paltser
310 schema:givenName Geoffrey
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624674775.82
312 rdf:type schema:Person
313 sg:person.0647511412.22 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
314 schema:familyName Tsui
315 schema:givenName Hubert
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647511412.22
317 rdf:type schema:Person
318 sg:person.0655032722.01 schema:affiliation https://www.grid.ac/institutes/grid.17063.33
319 schema:familyName Winer
320 schema:givenName Shawn
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655032722.01
322 rdf:type schema:Person
323 sg:person.0760172055.71 schema:affiliation https://www.grid.ac/institutes/grid.414123.1
324 schema:familyName Wadia
325 schema:givenName Persis P
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760172055.71
327 rdf:type schema:Person
328 sg:pub.10.1007/s00125-010-1730-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1000967259
329 https://doi.org/10.1007/s00125-010-1730-z
330 rdf:type schema:CreativeWork
331 sg:pub.10.1038/350423a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018596250
332 https://doi.org/10.1038/350423a0
333 rdf:type schema:CreativeWork
334 sg:pub.10.1038/35053000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000422653
335 https://doi.org/10.1038/35053000
336 rdf:type schema:CreativeWork
337 sg:pub.10.1038/nm.1961 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006257367
338 https://doi.org/10.1038/nm.1961
339 rdf:type schema:CreativeWork
340 sg:pub.10.1038/nm.1964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018401818
341 https://doi.org/10.1038/nm.1964
342 rdf:type schema:CreativeWork
343 sg:pub.10.1038/nm.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003810856
344 https://doi.org/10.1038/nm.2001
345 rdf:type schema:CreativeWork
346 sg:pub.10.1038/nm.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047056251
347 https://doi.org/10.1038/nm.2002
348 rdf:type schema:CreativeWork
349 sg:pub.10.1038/nri2206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005072972
350 https://doi.org/10.1038/nri2206
351 rdf:type schema:CreativeWork
352 sg:pub.10.1186/1477-7819-4-89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050525124
353 https://doi.org/10.1186/1477-7819-4-89
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1016/j.bbrc.2009.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021566716
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1016/j.cell.2010.02.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038658162
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1016/j.cmet.2008.08.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030994919
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1016/j.febslet.2005.05.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028045635
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1016/j.jhep.2007.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053058293
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1016/s0022-1759(98)00015-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040286227
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1016/s0092-8674(00)80191-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015811014
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1056/nejmoa0904130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050674315
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1073/pnas.0709205105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000626748
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1073/pnas.0908771107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027128137
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1074/jbc.m109.074252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003975297
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1084/jem.20100155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021025743
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1111/j.1464-5491.2009.02911.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009070382
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1111/j.1600-065x.2008.00646.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044885138
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1126/science.1061620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445120
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1126/science.7678183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648363
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1146/annurev-physiol-021909-135846 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020792537
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1161/circresaha.108.177105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052378051
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1172/jci19246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416393
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1172/jci19451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416401
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1172/jci29881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006797069
396 rdf:type schema:CreativeWork
397 https://doi.org/10.1172/jci36030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000380837
398 rdf:type schema:CreativeWork
399 https://doi.org/10.1172/jci38388 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001252705
400 rdf:type schema:CreativeWork
401 https://doi.org/10.1182/blood-2008-02-078071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035190574
402 rdf:type schema:CreativeWork
403 https://doi.org/10.1194/jlr.m500294-jlr200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025855230
404 rdf:type schema:CreativeWork
405 https://doi.org/10.1210/jc.2008-2354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064291075
406 rdf:type schema:CreativeWork
407 https://doi.org/10.1210/jc.85.1.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064301029
408 rdf:type schema:CreativeWork
409 https://doi.org/10.2337/db06-1076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050697274
410 rdf:type schema:CreativeWork
411 https://doi.org/10.2337/db07-0767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044551823
412 rdf:type schema:CreativeWork
413 https://doi.org/10.2337/db09-0323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032084369
414 rdf:type schema:CreativeWork
415 https://doi.org/10.2337/diabetes.53.2.336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012873980
416 rdf:type schema:CreativeWork
417 https://doi.org/10.4049/jimmunol.0903009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020381423
418 rdf:type schema:CreativeWork
419 https://doi.org/10.4049/jimmunol.1000021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007779929
420 rdf:type schema:CreativeWork
421 https://doi.org/10.4049/jimmunol.180.1.361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020390569
422 rdf:type schema:CreativeWork
423 https://www.grid.ac/institutes/grid.168010.e schema:alternateName Stanford University
424 schema:name Division of Endocrinology, Stanford University School of Medicine, Palo Alto, California, USA.
425 rdf:type schema:Organization
426 https://www.grid.ac/institutes/grid.17063.33 schema:alternateName University of Toronto
427 schema:name Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
428 Department of Pathology, Stanford University, Palo Alto, California, USA.
429 Neuroscience & Mental Health Program, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
430 rdf:type schema:Organization
431 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
432 schema:name Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA.
433 rdf:type schema:Organization
434 https://www.grid.ac/institutes/grid.414123.1 schema:alternateName Lucile Packard Children's Hospital
435 schema:name Department of Medicine, Stanford University, Palo Alto, California, USA.
436 Department of Pathology, Stanford University, Palo Alto, California, USA.
437 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...