Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04

AUTHORS

Siyuan Zhang, Wen-Chien Huang, Ping Li, Hua Guo, Say-Bee Poh, Samuel W Brady, Yan Xiong, Ling-Ming Tseng, Shau-Hsuan Li, Zhaoxi Ding, Aysegul A Sahin, Francisco J Esteva, Gabriel N Hortobagyi, Dihua Yu

ABSTRACT

Trastuzumab is a successful rationally designed ERBB2-targeted therapy. However, about half of individuals with ERBB2-overexpressing breast cancer do not respond to trastuzumab-based therapies, owing to various resistance mechanisms. Clinically applicable regimens for overcoming trastuzumab resistance of different mechanisms are not yet available. We show that the nonreceptor tyrosine kinase c-SRC (SRC) is a key modulator of trastuzumab response and a common node downstream of multiple trastuzumab resistance pathways. We find that SRC is activated in both acquired and de novo trastuzumab-resistant cells and uncover a novel mechanism of SRC regulation involving dephosphorylation by PTEN. Increased SRC activation conferred considerable trastuzumab resistance in breast cancer cells and correlated with trastuzumab resistance in patients. Targeting SRC in combination with trastuzumab sensitized multiple lines of trastuzumab-resistant cells to trastuzumab and eliminated trastuzumab-resistant tumors in vivo, suggesting the potential clinical application of this strategy to overcome trastuzumab resistance. More... »

PAGES

461

References to SciGraph publications

  • 2002-04. Src kinase contributes to the metastatic spread of carcinoma cells in ONCOGENE
  • 2008-02. STAT3 as a target for inducing apoptosis in solid and hematological tumors in CELL RESEARCH
  • 2000-08. Regulation of both apoptosis and cell survival by the v-Src oncoprotein in CELL DEATH & DIFFERENTIATION
  • 2004-02. FAK–Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly in NATURE CELL BIOLOGY
  • 2003-12. PI3K/Akt and apoptosis: size matters in ONCOGENE
  • 2001-03. Src family kinases and HER2 interactions in human breast cancer cell growth and survival in ONCOGENE
  • 2006-06. Upregulation and activation of PKCα by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKCα and Src inhibitors in ONCOGENE
  • 2007-04. Three-dimensional culture models of normal and malignant breast epithelial cells in NATURE METHODS
  • 1997-05. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome in NATURE GENETICS
  • 2007-05. c-Src modulates ErbB2 and ErbB3 heterocomplex formation and function in ONCOGENE
  • 2010-08. EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance in BREAST CANCER RESEARCH AND TREATMENT
  • 2004-10. The interplay between Src family kinases and receptor tyrosine kinases in ONCOGENE
  • 2009-07. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3 in NATURE REVIEWS CANCER
  • 1999-08. Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.2309

    DOI

    http://dx.doi.org/10.1038/nm.2309

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1025284851

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21399647


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