Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-05-23

AUTHORS

Siyoung Yang, Jonghwan Kim, Je-Hwang Ryu, Hwanhee Oh, Churl-Hong Chun, Byoung Ju Kim, Byoung Hyun Min, Jang-Soo Chun

ABSTRACT

In two studies from teams led by Hiroshi Kawaguchi and Jang-Soo Chun, a role for HIF-2α in osteoarthritis has been uncovered. Along with identifying the molecular mechanism, the teams found that HIF-2α expression is increased in human osteoarthritic tissue, and mice deficient for the protein are protected in two osteoarthritis models, suggesting that HIF-2A could be a therapeutic target. More... »

PAGES

687-693

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.2153

DOI

http://dx.doi.org/10.1038/nm.2153

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015200169

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20495569


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