T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04

AUTHORS

Robert C Axtell, Brigit A de Jong, Katia Boniface, Laura F van der Voort, Roopa Bhat, Patrizia De Sarno, Rodrigo Naves, May Han, Franklin Zhong, Jim G Castellanos, Robert Mair, Athena Christakos, Ilan Kolkowitz, Liat Katz, Joep Killestein, Chris H Polman, René de Waal Malefyt, Lawrence Steinman, Chander Raman

ABSTRACT

Interferon-beta (IFN-beta) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-beta in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS). IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, the amount of IL-10 was unaltered by treatment, although, unexpectedly, IFN-beta treatment still reduced IL-17 production without benefit. Both inhibition of IL-17 and induction of IL-10 depended on IFN-gamma. In the absence of IFN-gamma signaling, IFN-beta therapy was ineffective in EAE. In RRMS patients, IFN-beta nonresponders had higher IL-17F concentrations in serum compared to responders. Nonresponders had worse disease with more steroid usage and more relapses than did responders. Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta. More... »

PAGES

406

References to SciGraph publications

  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2007-12. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology in NATURE IMMUNOLOGY
  • 2005-11. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages in NATURE IMMUNOLOGY
  • 2007-09. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways in NATURE IMMUNOLOGY
  • 2005-05. Mechanisms of type-I- and type-II-interferon-mediated signalling in NATURE REVIEWS IMMUNOLOGY
  • 2009-03. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo in NATURE IMMUNOLOGY
  • 2006-09. At once harmful and beneficial: the dual properties of NF-κB in NATURE IMMUNOLOGY
  • 2000-07. Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox in NATURE IMMUNOLOGY
  • 2006-11. Early Relapse in Multiple Sclerosis-Associated Optic Neuritis Following the Use of Interferon b-1a in Chinese Patients in JAPANESE JOURNAL OF OPHTHALMOLOGY
  • 2008-02. Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis in JOURNAL OF NEUROLOGY
  • 2007-12. A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells in NATURE IMMUNOLOGY
  • 2007-12. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.2110

    DOI

    http://dx.doi.org/10.1038/nm.2110

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053047527

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20348925


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Encephalomyelitis, Autoimmune, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-Stimulated Gene Factor 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-beta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-gamma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-10", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-17", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiple Sclerosis, Relapsing-Remitting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spleen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocyte Subsets", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Helper-Inducer", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Th1 Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Axtell", 
            "givenName": "Robert C", 
            "id": "sg:person.0761670435.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761670435.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.", 
                "Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.", 
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Jong", 
            "givenName": "Brigit A", 
            "id": "sg:person.011376273322.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011376273322.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boniface", 
            "givenName": "Katia", 
            "id": "sg:person.0653001422.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653001422.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Voort", 
            "givenName": "Laura F", 
            "id": "sg:person.0753420210.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753420210.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhat", 
            "givenName": "Roopa", 
            "id": "sg:person.01361140714.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361140714.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Sarno", 
            "givenName": "Patrizia", 
            "id": "sg:person.0600015434.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600015434.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naves", 
            "givenName": "Rodrigo", 
            "id": "sg:person.0672444730.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672444730.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Han", 
            "givenName": "May", 
            "id": "sg:person.010373541572.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010373541572.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhong", 
            "givenName": "Franklin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castellanos", 
            "givenName": "Jim G", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mair", 
            "givenName": "Robert", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christakos", 
            "givenName": "Athena", 
            "id": "sg:person.01272413523.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272413523.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolkowitz", 
            "givenName": "Ilan", 
            "id": "sg:person.01040423451.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040423451.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katz", 
            "givenName": "Liat", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Killestein", 
            "givenName": "Joep", 
            "id": "sg:person.01306172116.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306172116.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Polman", 
            "givenName": "Chris H", 
            "id": "sg:person.0651353313.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651353313.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Waal Malefyt", 
            "givenName": "Ren\u00e9", 
            "id": "sg:person.0707272673.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707272673.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steinman", 
            "givenName": "Lawrence", 
            "id": "sg:person.01317762565.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317762565.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raman", 
            "givenName": "Chander", 
            "id": "sg:person.01353576730.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353576730.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ni1539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001933444", 
              "https://doi.org/10.1038/ni1539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002269423", 
              "https://doi.org/10.1038/ni1488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731283", 
              "https://doi.org/10.1038/nri1604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731283", 
              "https://doi.org/10.1038/nri1604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.2.609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003814847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3083.2006.01880.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005484957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clineuro.2005.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006575627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007751866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009201806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20041257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013395893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0906-901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017378366", 
              "https://doi.org/10.1038/ni0906-901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0906-901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017378366", 
              "https://doi.org/10.1038/ni0906-901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.25.14863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020882317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021136380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jns.2006.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025788510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026364890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1352458506070145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1352458506070145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1352458506070145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2008.12.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028507352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031138082", 
              "https://doi.org/10.1038/ni.1698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-007-0730-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031748544", 
              "https://doi.org/10.1007/s00415-007-0730-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-007-0730-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031748544", 
              "https://doi.org/10.1007/s00415-007-0730-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031832608", 
              "https://doi.org/10.1038/ni1541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci33342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031873795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/76940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039589847", 
              "https://doi.org/10.1038/76940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/76940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039589847", 
              "https://doi.org/10.1038/76940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040134526", 
              "https://doi.org/10.1038/ni1540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10384-006-0359-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040330415", 
              "https://doi.org/10.1007/s10384-006-0359-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10384-006-0359-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040330415", 
              "https://doi.org/10.1007/s10384-006-0359-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10384-006-0359-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040330415", 
              "https://doi.org/10.1007/s10384-006-0359-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.med.50.1.291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041449659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2008.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045774017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2007.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048775175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awf151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050485749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051485127", 
              "https://doi.org/10.1038/ni1254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051485127", 
              "https://doi.org/10.1038/ni1254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/stke.4162007pe70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062694143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076195014", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.8.5195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077303874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.11.7791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077521327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.12.8274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077528275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083256084", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083268893", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-04", 
        "datePublishedReg": "2010-04-01", 
        "description": "Interferon-beta (IFN-beta) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-beta in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS). IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, the amount of IL-10 was unaltered by treatment, although, unexpectedly, IFN-beta treatment still reduced IL-17 production without benefit. Both inhibition of IL-17 and induction of IL-10 depended on IFN-gamma. In the absence of IFN-gamma signaling, IFN-beta therapy was ineffective in EAE. In RRMS patients, IFN-beta nonresponders had higher IL-17F concentrations in serum compared to responders. Nonresponders had worse disease with more steroid usage and more relapses than did responders. Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm.2110", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2682334", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2458180", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2681759", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2561815", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5153328", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "T helper type 1 and 17 cells determine efficacy of interferon-\u03b2 in multiple sclerosis and experimental encephalomyelitis", 
        "pagination": "406", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fcadd3ca999e627167bbe6f5e5be87f4a62533bf48260bd61593df0e1484dcd7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20348925"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm.2110"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053047527"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm.2110", 
          "https://app.dimensions.ai/details/publication/pub.1053047527"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54307_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nm.2110"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      82 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm.2110 schema:about N00438b866039497fbe86e455dee4b7f6
    2 N0ba8276f20fc45a8add39112c6f1b4de
    3 N28e57bdf4ae0494fb50d0118ed3ff89f
    4 N52d08f45f21240468200e8db7e4d7bc4
    5 N6f221da1591d4726864d5cefdbccc223
    6 N86a0b310594d4753bf4b18f1b7082d6e
    7 N87984534b71244adb16c97b0f8db8c93
    8 N87b46bb954c643eb8cff27de95e92e94
    9 N8b40af86d5df4575be3df66ede214699
    10 N940f19688b2f489b8f3a3d8b970cc7d7
    11 Na628c3c35ce74c85b20933acd65b6003
    12 Na6a61b7ce78847539c13c9288be4c2e6
    13 Na75a40be4b824f42af94291c52c02af0
    14 Nabe4239eeae7493ca86b1ef16519eb5b
    15 Nafdf37c54db0415abd894a2eb3f89eba
    16 Nb3bd41772c674d05b29cf48e24c77d1a
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author Nc9e99e39aa114e65864b3255f2bb82eb
    20 schema:citation sg:pub.10.1007/s00415-007-0730-5
    21 sg:pub.10.1007/s10384-006-0359-4
    22 sg:pub.10.1038/76940
    23 sg:pub.10.1038/nature04753
    24 sg:pub.10.1038/nature04754
    25 sg:pub.10.1038/ni.1698
    26 sg:pub.10.1038/ni0906-901
    27 sg:pub.10.1038/ni1254
    28 sg:pub.10.1038/ni1488
    29 sg:pub.10.1038/ni1539
    30 sg:pub.10.1038/ni1540
    31 sg:pub.10.1038/ni1541
    32 sg:pub.10.1038/nri1604
    33 https://app.dimensions.ai/details/publication/pub.1076195014
    34 https://app.dimensions.ai/details/publication/pub.1083256084
    35 https://app.dimensions.ai/details/publication/pub.1083268893
    36 https://doi.org/10.1016/j.clineuro.2005.10.011
    37 https://doi.org/10.1016/j.cyto.2008.12.019
    38 https://doi.org/10.1016/j.immuni.2006.01.001
    39 https://doi.org/10.1016/j.immuni.2008.03.011
    40 https://doi.org/10.1016/j.jneuroim.2007.01.011
    41 https://doi.org/10.1016/j.jns.2006.10.008
    42 https://doi.org/10.1016/j.molimm.2008.06.006
    43 https://doi.org/10.1073/pnas.95.25.14863
    44 https://doi.org/10.1084/jem.20041257
    45 https://doi.org/10.1093/brain/awf151
    46 https://doi.org/10.1093/brain/awh453
    47 https://doi.org/10.1111/j.1365-3083.2006.01880.x
    48 https://doi.org/10.1126/stke.4162007pe70
    49 https://doi.org/10.1146/annurev.med.50.1.291
    50 https://doi.org/10.1172/jci33342
    51 https://doi.org/10.1172/jci35997
    52 https://doi.org/10.1177/1352458506070145
    53 https://doi.org/10.4049/jimmunol.174.2.609
    54 https://doi.org/10.4049/jimmunol.177.8.5195
    55 https://doi.org/10.4049/jimmunol.179.11.7791
    56 https://doi.org/10.4049/jimmunol.179.12.8274
    57 schema:datePublished 2010-04
    58 schema:datePublishedReg 2010-04-01
    59 schema:description Interferon-beta (IFN-beta) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-beta in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS). IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, the amount of IL-10 was unaltered by treatment, although, unexpectedly, IFN-beta treatment still reduced IL-17 production without benefit. Both inhibition of IL-17 and induction of IL-10 depended on IFN-gamma. In the absence of IFN-gamma signaling, IFN-beta therapy was ineffective in EAE. In RRMS patients, IFN-beta nonresponders had higher IL-17F concentrations in serum compared to responders. Nonresponders had worse disease with more steroid usage and more relapses than did responders. Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree true
    63 schema:isPartOf N7e8bf8e27c894e179008a81242ebf6ee
    64 Nb4c7f41f4d7f488a96b8a66b0e3d3213
    65 sg:journal.1113716
    66 schema:name T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
    67 schema:pagination 406
    68 schema:productId N23556ec293194113b7e1fe7f4d918875
    69 N3ac2f46d826749fbb128ad72f31ab7c2
    70 N89c56bf9fd544c3c921e1fea5fa92f29
    71 Nbbccda0d781e47edbd3c10c1adfc599c
    72 Ndb6c40df7cea4b42ab2de131ac96ded5
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053047527
    74 https://doi.org/10.1038/nm.2110
    75 schema:sdDatePublished 2019-04-11T10:17
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher Ndf4fe7bffff64a3aa3bc1b010f3af988
    78 schema:url https://www.nature.com/articles/nm.2110
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N00438b866039497fbe86e455dee4b7f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Animals
    84 rdf:type schema:DefinedTerm
    85 N08d70622be8145a7b0a63274c8abd33a rdf:first sg:person.0600015434.90
    86 rdf:rest N5ac52bd1fac341fd811e1890b5f9ed38
    87 N0ba8276f20fc45a8add39112c6f1b4de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Interferon-beta
    89 rdf:type schema:DefinedTerm
    90 N0c5185016fbd4e5c9f7f552036f85536 rdf:first sg:person.01353576730.35
    91 rdf:rest rdf:nil
    92 N0f0c4b53b48a4e668566df1bdb758fcc rdf:first N7ba135c45b294c7bb18ff46a2a231f9b
    93 rdf:rest N6969d1c6ae174f78a1a29efbf3704fd0
    94 N175666b6a7634e47a584585955504d5e schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    95 schema:familyName Castellanos
    96 schema:givenName Jim G
    97 rdf:type schema:Person
    98 N1a1bcee7d3b5446d80e3a1e98e16376f rdf:first sg:person.01272413523.10
    99 rdf:rest N6eab3aba556d4f0f9227de77f36caa33
    100 N23556ec293194113b7e1fe7f4d918875 schema:name doi
    101 schema:value 10.1038/nm.2110
    102 rdf:type schema:PropertyValue
    103 N28e57bdf4ae0494fb50d0118ed3ff89f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Multiple Sclerosis, Relapsing-Remitting
    105 rdf:type schema:DefinedTerm
    106 N2fd7bea3511647e09d78a19fdfc4e491 rdf:first sg:person.0653001422.65
    107 rdf:rest N4b2451afc1134843bac0eca987550fbd
    108 N3116e47304924abfa2b2c72afe56af04 rdf:first sg:person.010373541572.46
    109 rdf:rest N0f0c4b53b48a4e668566df1bdb758fcc
    110 N3ac2f46d826749fbb128ad72f31ab7c2 schema:name nlm_unique_id
    111 schema:value 9502015
    112 rdf:type schema:PropertyValue
    113 N4a08d6280a8f4ed1ab3d017dd0b851f3 rdf:first sg:person.0707272673.85
    114 rdf:rest N6efdeadb0e0a416cb803c4973edaedb6
    115 N4b2451afc1134843bac0eca987550fbd rdf:first sg:person.0753420210.80
    116 rdf:rest N98a3cffaa13c44a4a05f6520bbadd49a
    117 N4b9eec970e74467795e5cb0ce5082bf1 rdf:first N7fa3d915b4c6432dab790aec5c7a1c49
    118 rdf:rest N70488fa489994ba88e8104e3fc5b40b6
    119 N52d08f45f21240468200e8db7e4d7bc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name CD4-Positive T-Lymphocytes
    121 rdf:type schema:DefinedTerm
    122 N5ac52bd1fac341fd811e1890b5f9ed38 rdf:first sg:person.0672444730.93
    123 rdf:rest N3116e47304924abfa2b2c72afe56af04
    124 N6969d1c6ae174f78a1a29efbf3704fd0 rdf:first N175666b6a7634e47a584585955504d5e
    125 rdf:rest N80c5da5b569b4a0c850a7b7af1820e0d
    126 N6eab3aba556d4f0f9227de77f36caa33 rdf:first sg:person.01040423451.38
    127 rdf:rest N4b9eec970e74467795e5cb0ce5082bf1
    128 N6efdeadb0e0a416cb803c4973edaedb6 rdf:first sg:person.01317762565.74
    129 rdf:rest N0c5185016fbd4e5c9f7f552036f85536
    130 N6f221da1591d4726864d5cefdbccc223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Signal Transduction
    132 rdf:type schema:DefinedTerm
    133 N70488fa489994ba88e8104e3fc5b40b6 rdf:first sg:person.01306172116.31
    134 rdf:rest N83530298a9644dd3bca8a069c7e59dd6
    135 N7ba135c45b294c7bb18ff46a2a231f9b schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    136 schema:familyName Zhong
    137 schema:givenName Franklin
    138 rdf:type schema:Person
    139 N7e2b2d08ed5b4cc986b42f1b34c4fd20 rdf:first sg:person.011376273322.76
    140 rdf:rest N2fd7bea3511647e09d78a19fdfc4e491
    141 N7e8bf8e27c894e179008a81242ebf6ee schema:volumeNumber 16
    142 rdf:type schema:PublicationVolume
    143 N7fa3d915b4c6432dab790aec5c7a1c49 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    144 schema:familyName Katz
    145 schema:givenName Liat
    146 rdf:type schema:Person
    147 N80c5da5b569b4a0c850a7b7af1820e0d rdf:first N95d50abde3b547378552533661812637
    148 rdf:rest N1a1bcee7d3b5446d80e3a1e98e16376f
    149 N83530298a9644dd3bca8a069c7e59dd6 rdf:first sg:person.0651353313.70
    150 rdf:rest N4a08d6280a8f4ed1ab3d017dd0b851f3
    151 N86a0b310594d4753bf4b18f1b7082d6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Spleen
    153 rdf:type schema:DefinedTerm
    154 N87984534b71244adb16c97b0f8db8c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Interferon-gamma
    156 rdf:type schema:DefinedTerm
    157 N87b46bb954c643eb8cff27de95e92e94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Th1 Cells
    159 rdf:type schema:DefinedTerm
    160 N89c56bf9fd544c3c921e1fea5fa92f29 schema:name readcube_id
    161 schema:value fcadd3ca999e627167bbe6f5e5be87f4a62533bf48260bd61593df0e1484dcd7
    162 rdf:type schema:PropertyValue
    163 N8b40af86d5df4575be3df66ede214699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name T-Lymphocytes, Helper-Inducer
    165 rdf:type schema:DefinedTerm
    166 N940f19688b2f489b8f3a3d8b970cc7d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Interferon-Stimulated Gene Factor 3
    168 rdf:type schema:DefinedTerm
    169 N95d50abde3b547378552533661812637 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    170 schema:familyName Mair
    171 schema:givenName Robert
    172 rdf:type schema:Person
    173 N98a3cffaa13c44a4a05f6520bbadd49a rdf:first sg:person.01361140714.50
    174 rdf:rest N08d70622be8145a7b0a63274c8abd33a
    175 Na628c3c35ce74c85b20933acd65b6003 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Encephalomyelitis, Autoimmune, Experimental
    177 rdf:type schema:DefinedTerm
    178 Na6a61b7ce78847539c13c9288be4c2e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name T-Lymphocyte Subsets
    180 rdf:type schema:DefinedTerm
    181 Na75a40be4b824f42af94291c52c02af0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Interleukin-17
    183 rdf:type schema:DefinedTerm
    184 Nabe4239eeae7493ca86b1ef16519eb5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Mice
    186 rdf:type schema:DefinedTerm
    187 Nafdf37c54db0415abd894a2eb3f89eba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Interleukin-10
    189 rdf:type schema:DefinedTerm
    190 Nb3bd41772c674d05b29cf48e24c77d1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Humans
    192 rdf:type schema:DefinedTerm
    193 Nb4c7f41f4d7f488a96b8a66b0e3d3213 schema:issueNumber 4
    194 rdf:type schema:PublicationIssue
    195 Nb59c2a1ba72148d1ac43e4e4a38b041e schema:name Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA.
    196 rdf:type schema:Organization
    197 Nbbccda0d781e47edbd3c10c1adfc599c schema:name dimensions_id
    198 schema:value pub.1053047527
    199 rdf:type schema:PropertyValue
    200 Nc9e99e39aa114e65864b3255f2bb82eb rdf:first sg:person.0761670435.08
    201 rdf:rest N7e2b2d08ed5b4cc986b42f1b34c4fd20
    202 Ndb6c40df7cea4b42ab2de131ac96ded5 schema:name pubmed_id
    203 schema:value 20348925
    204 rdf:type schema:PropertyValue
    205 Ndf4fe7bffff64a3aa3bc1b010f3af988 schema:name Springer Nature - SN SciGraph project
    206 rdf:type schema:Organization
    207 Ne7dc79d6f1964e86a654105f037fafd2 schema:name Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA.
    208 rdf:type schema:Organization
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Clinical Sciences
    214 rdf:type schema:DefinedTerm
    215 sg:grant.2458180 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    216 rdf:type schema:MonetaryGrant
    217 sg:grant.2561815 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2681759 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2682334 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.5153328 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    224 rdf:type schema:MonetaryGrant
    225 sg:journal.1113716 schema:issn 1078-8956
    226 1546-170X
    227 schema:name Nature Medicine
    228 rdf:type schema:Periodical
    229 sg:person.010373541572.46 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    230 schema:familyName Han
    231 schema:givenName May
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010373541572.46
    233 rdf:type schema:Person
    234 sg:person.01040423451.38 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    235 schema:familyName Kolkowitz
    236 schema:givenName Ilan
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040423451.38
    238 rdf:type schema:Person
    239 sg:person.011376273322.76 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    240 schema:familyName de Jong
    241 schema:givenName Brigit A
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011376273322.76
    243 rdf:type schema:Person
    244 sg:person.01272413523.10 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    245 schema:familyName Christakos
    246 schema:givenName Athena
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272413523.10
    248 rdf:type schema:Person
    249 sg:person.01306172116.31 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    250 schema:familyName Killestein
    251 schema:givenName Joep
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306172116.31
    253 rdf:type schema:Person
    254 sg:person.01317762565.74 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    255 schema:familyName Steinman
    256 schema:givenName Lawrence
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317762565.74
    258 rdf:type schema:Person
    259 sg:person.01353576730.35 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    260 schema:familyName Raman
    261 schema:givenName Chander
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353576730.35
    263 rdf:type schema:Person
    264 sg:person.01361140714.50 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    265 schema:familyName Bhat
    266 schema:givenName Roopa
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361140714.50
    268 rdf:type schema:Person
    269 sg:person.0600015434.90 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    270 schema:familyName De Sarno
    271 schema:givenName Patrizia
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600015434.90
    273 rdf:type schema:Person
    274 sg:person.0651353313.70 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    275 schema:familyName Polman
    276 schema:givenName Chris H
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651353313.70
    278 rdf:type schema:Person
    279 sg:person.0653001422.65 schema:affiliation Ne7dc79d6f1964e86a654105f037fafd2
    280 schema:familyName Boniface
    281 schema:givenName Katia
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653001422.65
    283 rdf:type schema:Person
    284 sg:person.0672444730.93 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    285 schema:familyName Naves
    286 schema:givenName Rodrigo
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672444730.93
    288 rdf:type schema:Person
    289 sg:person.0707272673.85 schema:affiliation Nb59c2a1ba72148d1ac43e4e4a38b041e
    290 schema:familyName de Waal Malefyt
    291 schema:givenName René
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707272673.85
    293 rdf:type schema:Person
    294 sg:person.0753420210.80 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    295 schema:familyName van der Voort
    296 schema:givenName Laura F
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753420210.80
    298 rdf:type schema:Person
    299 sg:person.0761670435.08 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    300 schema:familyName Axtell
    301 schema:givenName Robert C
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761670435.08
    303 rdf:type schema:Person
    304 sg:pub.10.1007/s00415-007-0730-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031748544
    305 https://doi.org/10.1007/s00415-007-0730-5
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s10384-006-0359-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040330415
    308 https://doi.org/10.1007/s10384-006-0359-4
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/76940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039589847
    311 https://doi.org/10.1038/76940
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    314 https://doi.org/10.1038/nature04753
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    317 https://doi.org/10.1038/nature04754
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/ni.1698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138082
    320 https://doi.org/10.1038/ni.1698
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ni0906-901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017378366
    323 https://doi.org/10.1038/ni0906-901
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/ni1254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051485127
    326 https://doi.org/10.1038/ni1254
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/ni1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269423
    329 https://doi.org/10.1038/ni1488
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/ni1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001933444
    332 https://doi.org/10.1038/ni1539
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/ni1540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040134526
    335 https://doi.org/10.1038/ni1540
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/ni1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031832608
    338 https://doi.org/10.1038/ni1541
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nri1604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002731283
    341 https://doi.org/10.1038/nri1604
    342 rdf:type schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1076195014 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1083256084 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1083268893 schema:CreativeWork
    346 https://doi.org/10.1016/j.clineuro.2005.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006575627
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/j.cyto.2008.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028507352
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.immuni.2008.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026364890
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.jneuroim.2007.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048775175
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.jns.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025788510
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/j.molimm.2008.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045774017
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1084/jem.20041257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395893
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1093/brain/awf151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050485749
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1093/brain/awh453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021136380
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1365-3083.2006.01880.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005484957
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1126/stke.4162007pe70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062694143
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1146/annurev.med.50.1.291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041449659
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1172/jci33342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031873795
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1172/jci35997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007751866
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1177/1352458506070145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027687983
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.4049/jimmunol.174.2.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003814847
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.4049/jimmunol.177.8.5195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077303874
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.4049/jimmunol.179.11.7791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077521327
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.4049/jimmunol.179.12.8274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077528275
    387 rdf:type schema:CreativeWork
    388 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    389 schema:name Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
    390 Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
    391 Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
    392 rdf:type schema:Organization
    393 https://www.grid.ac/institutes/grid.240952.8 schema:alternateName Stanford Medicine
    394 schema:name Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
    395 rdf:type schema:Organization
    396 https://www.grid.ac/institutes/grid.265892.2 schema:alternateName University of Alabama at Birmingham
    397 schema:name Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
    398 Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...