T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04

AUTHORS

Robert C Axtell, Brigit A de Jong, Katia Boniface, Laura F van der Voort, Roopa Bhat, Patrizia De Sarno, Rodrigo Naves, May Han, Franklin Zhong, Jim G Castellanos, Robert Mair, Athena Christakos, Ilan Kolkowitz, Liat Katz, Joep Killestein, Chris H Polman, René de Waal Malefyt, Lawrence Steinman, Chander Raman

ABSTRACT

Interferon-beta (IFN-beta) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-beta in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS). IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, the amount of IL-10 was unaltered by treatment, although, unexpectedly, IFN-beta treatment still reduced IL-17 production without benefit. Both inhibition of IL-17 and induction of IL-10 depended on IFN-gamma. In the absence of IFN-gamma signaling, IFN-beta therapy was ineffective in EAE. In RRMS patients, IFN-beta nonresponders had higher IL-17F concentrations in serum compared to responders. Nonresponders had worse disease with more steroid usage and more relapses than did responders. Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta. More... »

PAGES

406

References to SciGraph publications

  • 2006-05. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells in NATURE
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2007-12. TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology in NATURE IMMUNOLOGY
  • 2005-11. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages in NATURE IMMUNOLOGY
  • 2007-09. IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways in NATURE IMMUNOLOGY
  • 2005-05. Mechanisms of type-I- and type-II-interferon-mediated signalling in NATURE REVIEWS IMMUNOLOGY
  • 2009-03. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo in NATURE IMMUNOLOGY
  • 2006-09. At once harmful and beneficial: the dual properties of NF-κB in NATURE IMMUNOLOGY
  • 2000-07. Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox in NATURE IMMUNOLOGY
  • 2006-11. Early Relapse in Multiple Sclerosis-Associated Optic Neuritis Following the Use of Interferon b-1a in Chinese Patients in JAPANESE JOURNAL OF OPHTHALMOLOGY
  • 2008-02. Development of extensive brain lesions following interferon beta therapy in relapsing neuromyelitis optica and longitudinally extensive myelitis in JOURNAL OF NEUROLOGY
  • 2007-12. A dominant function for interleukin 27 in generating interleukin 10–producing anti-inflammatory T cells in NATURE IMMUNOLOGY
  • 2007-12. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27–stimulated T cells in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.2110

    DOI

    http://dx.doi.org/10.1038/nm.2110

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053047527

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20348925


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "CD4-Positive T-Lymphocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Encephalomyelitis, Autoimmune, Experimental", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-Stimulated Gene Factor 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-beta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interferon-gamma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-10", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-17", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multiple Sclerosis, Relapsing-Remitting", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spleen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocyte Subsets", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "T-Lymphocytes, Helper-Inducer", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Th1 Cells", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Axtell", 
            "givenName": "Robert C", 
            "id": "sg:person.0761670435.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761670435.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.", 
                "Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.", 
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Jong", 
            "givenName": "Brigit A", 
            "id": "sg:person.011376273322.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011376273322.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boniface", 
            "givenName": "Katia", 
            "id": "sg:person.0653001422.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653001422.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "van der Voort", 
            "givenName": "Laura F", 
            "id": "sg:person.0753420210.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753420210.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bhat", 
            "givenName": "Roopa", 
            "id": "sg:person.01361140714.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361140714.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "De Sarno", 
            "givenName": "Patrizia", 
            "id": "sg:person.0600015434.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600015434.90"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naves", 
            "givenName": "Rodrigo", 
            "id": "sg:person.0672444730.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672444730.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Han", 
            "givenName": "May", 
            "id": "sg:person.010373541572.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010373541572.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhong", 
            "givenName": "Franklin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Castellanos", 
            "givenName": "Jim G", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mair", 
            "givenName": "Robert", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christakos", 
            "givenName": "Athena", 
            "id": "sg:person.01272413523.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272413523.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kolkowitz", 
            "givenName": "Ilan", 
            "id": "sg:person.01040423451.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040423451.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Katz", 
            "givenName": "Liat", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Killestein", 
            "givenName": "Joep", 
            "id": "sg:person.01306172116.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306172116.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "VU University Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.16872.3a", 
              "name": [
                "Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Polman", 
            "givenName": "Chris H", 
            "id": "sg:person.0651353313.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651353313.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "de Waal Malefyt", 
            "givenName": "Ren\u00e9", 
            "id": "sg:person.0707272673.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707272673.85"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Stanford Medicine", 
              "id": "https://www.grid.ac/institutes/grid.240952.8", 
              "name": [
                "Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Steinman", 
            "givenName": "Lawrence", 
            "id": "sg:person.01317762565.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317762565.74"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Alabama at Birmingham", 
              "id": "https://www.grid.ac/institutes/grid.265892.2", 
              "name": [
                "Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Raman", 
            "givenName": "Chander", 
            "id": "sg:person.01353576730.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353576730.35"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ni1539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001933444", 
              "https://doi.org/10.1038/ni1539"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1488", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002269423", 
              "https://doi.org/10.1038/ni1488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731283", 
              "https://doi.org/10.1038/nri1604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri1604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002731283", 
              "https://doi.org/10.1038/nri1604"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.174.2.609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003814847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3083.2006.01880.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005484957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clineuro.2005.10.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006575627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007751866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2006.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009201806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20041257", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013395893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0906-901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017378366", 
              "https://doi.org/10.1038/ni0906-901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0906-901", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017378366", 
              "https://doi.org/10.1038/ni0906-901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.25.14863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020882317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh453", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021136380"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jns.2006.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025788510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2008.03.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026364890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1352458506070145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1352458506070145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1352458506070145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cyto.2008.12.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028507352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031138082", 
              "https://doi.org/10.1038/ni.1698"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-007-0730-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031748544", 
              "https://doi.org/10.1007/s00415-007-0730-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-007-0730-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031748544", 
              "https://doi.org/10.1007/s00415-007-0730-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031832608", 
              "https://doi.org/10.1038/ni1541"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci33342", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031873795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04753", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037247321", 
              "https://doi.org/10.1038/nature04753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/76940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039589847", 
              "https://doi.org/10.1038/76940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/76940", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039589847", 
              "https://doi.org/10.1038/76940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040134526", 
              "https://doi.org/10.1038/ni1540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10384-006-0359-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040330415", 
              "https://doi.org/10.1007/s10384-006-0359-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10384-006-0359-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040330415", 
              "https://doi.org/10.1007/s10384-006-0359-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10384-006-0359-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040330415", 
              "https://doi.org/10.1007/s10384-006-0359-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.med.50.1.291", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041449659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043278106", 
              "https://doi.org/10.1038/nature04754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2008.06.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045774017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2007.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048775175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awf151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050485749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051485127", 
              "https://doi.org/10.1038/ni1254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1254", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051485127", 
              "https://doi.org/10.1038/ni1254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/stke.4162007pe70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062694143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076195014", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.8.5195", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077303874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.11.7791", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077521327"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.179.12.8274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077528275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083256084", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083268893", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-04", 
        "datePublishedReg": "2010-04-01", 
        "description": "Interferon-beta (IFN-beta) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-beta in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS). IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, the amount of IL-10 was unaltered by treatment, although, unexpectedly, IFN-beta treatment still reduced IL-17 production without benefit. Both inhibition of IL-17 and induction of IL-10 depended on IFN-gamma. In the absence of IFN-gamma signaling, IFN-beta therapy was ineffective in EAE. In RRMS patients, IFN-beta nonresponders had higher IL-17F concentrations in serum compared to responders. Nonresponders had worse disease with more steroid usage and more relapses than did responders. Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm.2110", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2682334", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2458180", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2681759", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2561815", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5153328", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "16"
          }
        ], 
        "name": "T helper type 1 and 17 cells determine efficacy of interferon-\u03b2 in multiple sclerosis and experimental encephalomyelitis", 
        "pagination": "406", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fcadd3ca999e627167bbe6f5e5be87f4a62533bf48260bd61593df0e1484dcd7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20348925"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm.2110"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1053047527"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm.2110", 
          "https://app.dimensions.ai/details/publication/pub.1053047527"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:17", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54307_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/nm.2110"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.2110'


     

    This table displays all metadata directly associated to this object as RDF triples.

    399 TRIPLES      21 PREDICATES      82 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm.2110 schema:about N07d973b1fe944e7c88e1ea61cc0fa48b
    2 N2083e666af9d4a36b1f6487015785695
    3 N2133898e30db4bc08b4df3c821fc738c
    4 N30b457393f1a46bf8707146ec23cfdd3
    5 N3c35ccd65e0b4241b913ef1560667912
    6 N52ab5d14f7b944b0a5e57122f83c011d
    7 N60d06f3b3c4544859514b000d432eb4d
    8 N624c480a27e946218f9fb393e566df19
    9 N746785cc2bd84d6ca1c667d92213b405
    10 Na9f129f46812436483de92fafbed6b3a
    11 Nb6460650761e4e53b91a149936af0351
    12 Nb817f3843e4a4f4ba52131073aa3663d
    13 Nb8283c9111f64932b864344e6cc28c8c
    14 Ncc564e8c4d7844e2a90ed77d736236ff
    15 Nd145cc5ce9b54ad7b334542d20b02926
    16 Nec69544e437c45b780125f11f7ddddd3
    17 anzsrc-for:11
    18 anzsrc-for:1103
    19 schema:author Nbfc31e8d6c444900ab2070ea261617b8
    20 schema:citation sg:pub.10.1007/s00415-007-0730-5
    21 sg:pub.10.1007/s10384-006-0359-4
    22 sg:pub.10.1038/76940
    23 sg:pub.10.1038/nature04753
    24 sg:pub.10.1038/nature04754
    25 sg:pub.10.1038/ni.1698
    26 sg:pub.10.1038/ni0906-901
    27 sg:pub.10.1038/ni1254
    28 sg:pub.10.1038/ni1488
    29 sg:pub.10.1038/ni1539
    30 sg:pub.10.1038/ni1540
    31 sg:pub.10.1038/ni1541
    32 sg:pub.10.1038/nri1604
    33 https://app.dimensions.ai/details/publication/pub.1076195014
    34 https://app.dimensions.ai/details/publication/pub.1083256084
    35 https://app.dimensions.ai/details/publication/pub.1083268893
    36 https://doi.org/10.1016/j.clineuro.2005.10.011
    37 https://doi.org/10.1016/j.cyto.2008.12.019
    38 https://doi.org/10.1016/j.immuni.2006.01.001
    39 https://doi.org/10.1016/j.immuni.2008.03.011
    40 https://doi.org/10.1016/j.jneuroim.2007.01.011
    41 https://doi.org/10.1016/j.jns.2006.10.008
    42 https://doi.org/10.1016/j.molimm.2008.06.006
    43 https://doi.org/10.1073/pnas.95.25.14863
    44 https://doi.org/10.1084/jem.20041257
    45 https://doi.org/10.1093/brain/awf151
    46 https://doi.org/10.1093/brain/awh453
    47 https://doi.org/10.1111/j.1365-3083.2006.01880.x
    48 https://doi.org/10.1126/stke.4162007pe70
    49 https://doi.org/10.1146/annurev.med.50.1.291
    50 https://doi.org/10.1172/jci33342
    51 https://doi.org/10.1172/jci35997
    52 https://doi.org/10.1177/1352458506070145
    53 https://doi.org/10.4049/jimmunol.174.2.609
    54 https://doi.org/10.4049/jimmunol.177.8.5195
    55 https://doi.org/10.4049/jimmunol.179.11.7791
    56 https://doi.org/10.4049/jimmunol.179.12.8274
    57 schema:datePublished 2010-04
    58 schema:datePublishedReg 2010-04-01
    59 schema:description Interferon-beta (IFN-beta) is the major treatment for multiple sclerosis. However, this treatment is not always effective. Here we have found congruence in outcome between responses to IFN-beta in experimental autoimmune encephalomyelitis (EAE) and relapsing-remitting multiple sclerosis (RRMS). IFN-beta was effective in reducing EAE symptoms induced by T helper type 1 (T(H)1) cells but exacerbated disease induced by T(H)17 cells. Effective treatment in T(H)1-induced EAE correlated with increased interleukin-10 (IL-10) production by splenocytes. In T(H)17-induced disease, the amount of IL-10 was unaltered by treatment, although, unexpectedly, IFN-beta treatment still reduced IL-17 production without benefit. Both inhibition of IL-17 and induction of IL-10 depended on IFN-gamma. In the absence of IFN-gamma signaling, IFN-beta therapy was ineffective in EAE. In RRMS patients, IFN-beta nonresponders had higher IL-17F concentrations in serum compared to responders. Nonresponders had worse disease with more steroid usage and more relapses than did responders. Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta.
    60 schema:genre research_article
    61 schema:inLanguage en
    62 schema:isAccessibleForFree true
    63 schema:isPartOf N59fd392690da4060937d2a6beb97fcc9
    64 Nc9c9219a0fd647f89c233b6d1f3b7971
    65 sg:journal.1113716
    66 schema:name T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
    67 schema:pagination 406
    68 schema:productId N39151b0ebb33458e8711dd3e29098a95
    69 N56844f7e2cdd405fbf3fb7630a3f94cf
    70 N5f1dfe866258490890f40d0165b76490
    71 N6aa369da867c492387b0bc93bb645761
    72 Ne98a2afec64640dd8d66c173d2950fc2
    73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053047527
    74 https://doi.org/10.1038/nm.2110
    75 schema:sdDatePublished 2019-04-11T10:17
    76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    77 schema:sdPublisher N01e1c66b39a04b2c948c81fb7a8435ec
    78 schema:url https://www.nature.com/articles/nm.2110
    79 sgo:license sg:explorer/license/
    80 sgo:sdDataset articles
    81 rdf:type schema:ScholarlyArticle
    82 N019aa6d677ba4de39a1253009b230831 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    83 schema:familyName Katz
    84 schema:givenName Liat
    85 rdf:type schema:Person
    86 N01e1c66b39a04b2c948c81fb7a8435ec schema:name Springer Nature - SN SciGraph project
    87 rdf:type schema:Organization
    88 N07d973b1fe944e7c88e1ea61cc0fa48b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Mice
    90 rdf:type schema:DefinedTerm
    91 N08172c2c9e8748c2a66668810ac65dfb rdf:first sg:person.01353576730.35
    92 rdf:rest rdf:nil
    93 N11f2e9fa55204cd585ba3509f6513c86 rdf:first N24d185e655484010823b74a6e72b3ecf
    94 rdf:rest Nb14d2eacb067405e8ffedf10e2bf5be2
    95 N1c3c1e2a70a54a91b6a76b0a1a5a6cdb rdf:first sg:person.0672444730.93
    96 rdf:rest N6582094ad3f84bb2b2a2590a5dbbc32e
    97 N2083e666af9d4a36b1f6487015785695 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Interleukin-10
    99 rdf:type schema:DefinedTerm
    100 N2133898e30db4bc08b4df3c821fc738c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Encephalomyelitis, Autoimmune, Experimental
    102 rdf:type schema:DefinedTerm
    103 N24d185e655484010823b74a6e72b3ecf schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    104 schema:familyName Mair
    105 schema:givenName Robert
    106 rdf:type schema:Person
    107 N2de568b07b6c444fb551da029639aab5 rdf:first sg:person.01306172116.31
    108 rdf:rest Na575a3415a0f47cd8a0c10d91f97bfaf
    109 N3072052a429946ec84a53acc53ee7486 rdf:first sg:person.01361140714.50
    110 rdf:rest N7cfe8837c9e6406886d8f858f12da2f1
    111 N30b457393f1a46bf8707146ec23cfdd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Signal Transduction
    113 rdf:type schema:DefinedTerm
    114 N39151b0ebb33458e8711dd3e29098a95 schema:name nlm_unique_id
    115 schema:value 9502015
    116 rdf:type schema:PropertyValue
    117 N3c35ccd65e0b4241b913ef1560667912 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Humans
    119 rdf:type schema:DefinedTerm
    120 N52ab5d14f7b944b0a5e57122f83c011d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Spleen
    122 rdf:type schema:DefinedTerm
    123 N56844f7e2cdd405fbf3fb7630a3f94cf schema:name pubmed_id
    124 schema:value 20348925
    125 rdf:type schema:PropertyValue
    126 N59fd392690da4060937d2a6beb97fcc9 schema:volumeNumber 16
    127 rdf:type schema:PublicationVolume
    128 N5f1dfe866258490890f40d0165b76490 schema:name readcube_id
    129 schema:value fcadd3ca999e627167bbe6f5e5be87f4a62533bf48260bd61593df0e1484dcd7
    130 rdf:type schema:PropertyValue
    131 N60d06f3b3c4544859514b000d432eb4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name T-Lymphocytes, Helper-Inducer
    133 rdf:type schema:DefinedTerm
    134 N624c480a27e946218f9fb393e566df19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Interferon-Stimulated Gene Factor 3
    136 rdf:type schema:DefinedTerm
    137 N6582094ad3f84bb2b2a2590a5dbbc32e rdf:first sg:person.010373541572.46
    138 rdf:rest N97f9112c371747a184319506e14ac86d
    139 N66bffbf3e41247329c54a36dfb2fbb4c rdf:first sg:person.0707272673.85
    140 rdf:rest N96b32f9311b644c6bc8d09cf5cedc39b
    141 N6aa369da867c492387b0bc93bb645761 schema:name doi
    142 schema:value 10.1038/nm.2110
    143 rdf:type schema:PropertyValue
    144 N746785cc2bd84d6ca1c667d92213b405 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name T-Lymphocyte Subsets
    146 rdf:type schema:DefinedTerm
    147 N7cfe8837c9e6406886d8f858f12da2f1 rdf:first sg:person.0600015434.90
    148 rdf:rest N1c3c1e2a70a54a91b6a76b0a1a5a6cdb
    149 N89b815d79b2f421db99a2e31d0519e4c schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    150 schema:familyName Castellanos
    151 schema:givenName Jim G
    152 rdf:type schema:Person
    153 N96b32f9311b644c6bc8d09cf5cedc39b rdf:first sg:person.01317762565.74
    154 rdf:rest N08172c2c9e8748c2a66668810ac65dfb
    155 N97f9112c371747a184319506e14ac86d rdf:first Ne3ca412791e240e9b8fc8e9f6f237be9
    156 rdf:rest Nf5fc49e9f1cc4feaa1eaff08592e19d7
    157 Na03c4672c4584e0d837388741bcde735 rdf:first sg:person.0753420210.80
    158 rdf:rest N3072052a429946ec84a53acc53ee7486
    159 Na19642d9254042c8b48f0015c4914cca rdf:first sg:person.01040423451.38
    160 rdf:rest Nec11a69cc345442e8b05d1ed567833e6
    161 Na575a3415a0f47cd8a0c10d91f97bfaf rdf:first sg:person.0651353313.70
    162 rdf:rest N66bffbf3e41247329c54a36dfb2fbb4c
    163 Na9f129f46812436483de92fafbed6b3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Multiple Sclerosis, Relapsing-Remitting
    165 rdf:type schema:DefinedTerm
    166 Nb14d2eacb067405e8ffedf10e2bf5be2 rdf:first sg:person.01272413523.10
    167 rdf:rest Na19642d9254042c8b48f0015c4914cca
    168 Nb463379ae1b145589571d5a77d0024fe rdf:first sg:person.0653001422.65
    169 rdf:rest Na03c4672c4584e0d837388741bcde735
    170 Nb6460650761e4e53b91a149936af0351 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    171 schema:name Th1 Cells
    172 rdf:type schema:DefinedTerm
    173 Nb817f3843e4a4f4ba52131073aa3663d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Interferon-beta
    175 rdf:type schema:DefinedTerm
    176 Nb8283c9111f64932b864344e6cc28c8c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Interferon-gamma
    178 rdf:type schema:DefinedTerm
    179 Nbfc31e8d6c444900ab2070ea261617b8 rdf:first sg:person.0761670435.08
    180 rdf:rest Nc68ffcf9b4364beeb13cf92240bc829b
    181 Nc68ffcf9b4364beeb13cf92240bc829b rdf:first sg:person.011376273322.76
    182 rdf:rest Nb463379ae1b145589571d5a77d0024fe
    183 Nc9c9219a0fd647f89c233b6d1f3b7971 schema:issueNumber 4
    184 rdf:type schema:PublicationIssue
    185 Ncc564e8c4d7844e2a90ed77d736236ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Interleukin-17
    187 rdf:type schema:DefinedTerm
    188 Nceb6afffae53484c96728c8ebcfaa82c schema:name Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA.
    189 rdf:type schema:Organization
    190 Nd145cc5ce9b54ad7b334542d20b02926 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name CD4-Positive T-Lymphocytes
    192 rdf:type schema:DefinedTerm
    193 Ne3ca412791e240e9b8fc8e9f6f237be9 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    194 schema:familyName Zhong
    195 schema:givenName Franklin
    196 rdf:type schema:Person
    197 Ne98a2afec64640dd8d66c173d2950fc2 schema:name dimensions_id
    198 schema:value pub.1053047527
    199 rdf:type schema:PropertyValue
    200 Nec11a69cc345442e8b05d1ed567833e6 rdf:first N019aa6d677ba4de39a1253009b230831
    201 rdf:rest N2de568b07b6c444fb551da029639aab5
    202 Nec69544e437c45b780125f11f7ddddd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Animals
    204 rdf:type schema:DefinedTerm
    205 Nf3fc300536414964bce31f02453c3502 schema:name Department of Immunology and Schering-Plough Biopharma, Palo Alto, California, USA.
    206 rdf:type schema:Organization
    207 Nf5fc49e9f1cc4feaa1eaff08592e19d7 rdf:first N89b815d79b2f421db99a2e31d0519e4c
    208 rdf:rest N11f2e9fa55204cd585ba3509f6513c86
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Clinical Sciences
    214 rdf:type schema:DefinedTerm
    215 sg:grant.2458180 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    216 rdf:type schema:MonetaryGrant
    217 sg:grant.2561815 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    218 rdf:type schema:MonetaryGrant
    219 sg:grant.2681759 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    220 rdf:type schema:MonetaryGrant
    221 sg:grant.2682334 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    222 rdf:type schema:MonetaryGrant
    223 sg:grant.5153328 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.2110
    224 rdf:type schema:MonetaryGrant
    225 sg:journal.1113716 schema:issn 1078-8956
    226 1546-170X
    227 schema:name Nature Medicine
    228 rdf:type schema:Periodical
    229 sg:person.010373541572.46 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    230 schema:familyName Han
    231 schema:givenName May
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010373541572.46
    233 rdf:type schema:Person
    234 sg:person.01040423451.38 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    235 schema:familyName Kolkowitz
    236 schema:givenName Ilan
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01040423451.38
    238 rdf:type schema:Person
    239 sg:person.011376273322.76 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    240 schema:familyName de Jong
    241 schema:givenName Brigit A
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011376273322.76
    243 rdf:type schema:Person
    244 sg:person.01272413523.10 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    245 schema:familyName Christakos
    246 schema:givenName Athena
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272413523.10
    248 rdf:type schema:Person
    249 sg:person.01306172116.31 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    250 schema:familyName Killestein
    251 schema:givenName Joep
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306172116.31
    253 rdf:type schema:Person
    254 sg:person.01317762565.74 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    255 schema:familyName Steinman
    256 schema:givenName Lawrence
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317762565.74
    258 rdf:type schema:Person
    259 sg:person.01353576730.35 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    260 schema:familyName Raman
    261 schema:givenName Chander
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353576730.35
    263 rdf:type schema:Person
    264 sg:person.01361140714.50 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    265 schema:familyName Bhat
    266 schema:givenName Roopa
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361140714.50
    268 rdf:type schema:Person
    269 sg:person.0600015434.90 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    270 schema:familyName De Sarno
    271 schema:givenName Patrizia
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600015434.90
    273 rdf:type schema:Person
    274 sg:person.0651353313.70 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    275 schema:familyName Polman
    276 schema:givenName Chris H
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651353313.70
    278 rdf:type schema:Person
    279 sg:person.0653001422.65 schema:affiliation Nceb6afffae53484c96728c8ebcfaa82c
    280 schema:familyName Boniface
    281 schema:givenName Katia
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653001422.65
    283 rdf:type schema:Person
    284 sg:person.0672444730.93 schema:affiliation https://www.grid.ac/institutes/grid.265892.2
    285 schema:familyName Naves
    286 schema:givenName Rodrigo
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0672444730.93
    288 rdf:type schema:Person
    289 sg:person.0707272673.85 schema:affiliation Nf3fc300536414964bce31f02453c3502
    290 schema:familyName de Waal Malefyt
    291 schema:givenName René
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707272673.85
    293 rdf:type schema:Person
    294 sg:person.0753420210.80 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
    295 schema:familyName van der Voort
    296 schema:givenName Laura F
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753420210.80
    298 rdf:type schema:Person
    299 sg:person.0761670435.08 schema:affiliation https://www.grid.ac/institutes/grid.240952.8
    300 schema:familyName Axtell
    301 schema:givenName Robert C
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761670435.08
    303 rdf:type schema:Person
    304 sg:pub.10.1007/s00415-007-0730-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031748544
    305 https://doi.org/10.1007/s00415-007-0730-5
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s10384-006-0359-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040330415
    308 https://doi.org/10.1007/s10384-006-0359-4
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/76940 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039589847
    311 https://doi.org/10.1038/76940
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nature04753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037247321
    314 https://doi.org/10.1038/nature04753
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nature04754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043278106
    317 https://doi.org/10.1038/nature04754
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/ni.1698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031138082
    320 https://doi.org/10.1038/ni.1698
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/ni0906-901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017378366
    323 https://doi.org/10.1038/ni0906-901
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/ni1254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051485127
    326 https://doi.org/10.1038/ni1254
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/ni1488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002269423
    329 https://doi.org/10.1038/ni1488
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1038/ni1539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001933444
    332 https://doi.org/10.1038/ni1539
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/ni1540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040134526
    335 https://doi.org/10.1038/ni1540
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/ni1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031832608
    338 https://doi.org/10.1038/ni1541
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nri1604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002731283
    341 https://doi.org/10.1038/nri1604
    342 rdf:type schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1076195014 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1083256084 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1083268893 schema:CreativeWork
    346 https://doi.org/10.1016/j.clineuro.2005.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006575627
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1016/j.cyto.2008.12.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028507352
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1016/j.immuni.2006.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009201806
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1016/j.immuni.2008.03.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026364890
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1016/j.jneuroim.2007.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048775175
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1016/j.jns.2006.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025788510
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1016/j.molimm.2008.06.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045774017
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1073/pnas.95.25.14863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020882317
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1084/jem.20041257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013395893
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1093/brain/awf151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050485749
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1093/brain/awh453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021136380
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1111/j.1365-3083.2006.01880.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005484957
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1126/stke.4162007pe70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062694143
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1146/annurev.med.50.1.291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041449659
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1172/jci33342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031873795
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1172/jci35997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007751866
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1177/1352458506070145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027687983
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.4049/jimmunol.174.2.609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003814847
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.4049/jimmunol.177.8.5195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077303874
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.4049/jimmunol.179.11.7791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077521327
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.4049/jimmunol.179.12.8274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077528275
    387 rdf:type schema:CreativeWork
    388 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
    389 schema:name Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
    390 Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
    391 Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands.
    392 rdf:type schema:Organization
    393 https://www.grid.ac/institutes/grid.240952.8 schema:alternateName Stanford Medicine
    394 schema:name Department of Neurology and Neurological Sciences, Stanford University, Stanford, California, USA.
    395 rdf:type schema:Organization
    396 https://www.grid.ac/institutes/grid.265892.2 schema:alternateName University of Alabama at Birmingham
    397 schema:name Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
    398 Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
    399 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...