A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05

AUTHORS

Stephen J Huffaker, Jingshan Chen, Kristin K Nicodemus, Fabio Sambataro, Feng Yang, Venkata Mattay, Barbara K Lipska, Thomas M Hyde, Jian Song, Dan Rujescu, Ina Giegling, Karine Mayilyan, Morgan J Proust, Armen Soghoyan, Grazia Caforio, Joseph H Callicott, Alessandro Bertolino, Andreas Meyer-Lindenberg, Jay Chang, Yuanyuan Ji, Michael F Egan, Terry E Goldberg, Joel E Kleinman, Bai Lu, Daniel R Weinberger

ABSTRACT

Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related K(+) channel KCNH2 that modulates neuronal firing. KCNH2-3.1 messenger RNA levels are comparable to full-length KCNH2 (1A) levels in brain but three orders of magnitude lower in heart. In hippocampus from individuals with schizophrenia, KCNH2-3.1 expression is 2.5-fold greater than KCNH2-1A expression. A meta-analysis of five clinical data sets (367 families, 1,158 unrelated cases and 1,704 controls) shows association of single nucleotide polymorphisms in KCNH2 with schizophrenia. Risk-associated alleles predict lower intelligence quotient scores and speed of cognitive processing, altered memory-linked functional magnetic resonance imaging signals and increased KCNH2-3.1 mRNA levels in postmortem hippocampus. KCNH2-3.1 lacks a domain that is crucial for slow channel deactivation. Overexpression of KCNH2-3.1 in primary cortical neurons induces a rapidly deactivating K(+) current and a high-frequency, nonadapting firing pattern. These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target. More... »

PAGES

509-518

References to SciGraph publications

  • 2007-06-07. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls in NATURE
  • 2008-09. Identification of loci associated with schizophrenia by genome-wide association and follow-up in NATURE GENETICS
  • 2004-07. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress in MOLECULAR PSYCHIATRY
  • 2007-06-07. Replicating genotype–phenotype associations in NATURE
  • 2008-06. Genomewide association for schizophrenia in the CATIE study: results of stage 1 in MOLECULAR PSYCHIATRY
  • 2008-07. Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database in NATURE GENETICS
  • 2006-04. Heterogeneity in the pyramidal network of the medial prefrontal cortex in NATURE NEUROSCIENCE
  • 2003-12. The International HapMap Project in NATURE
  • 2001-04. The family based association test method: strategies for studying general genotype–phenotype associations in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2004-07. Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress in MOLECULAR PSYCHIATRY
  • 2006-03. hERG potassium channels and cardiac arrhythmia in NATURE
  • 2003-03. Neural mechanisms of general fluid intelligence in NATURE NEUROSCIENCE
  • 2004-09. Establishment of genetic associations for complex diseases is independent of early study findings in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2000-10. How many diseases does it take to map a gene with SNPs? in NATURE GENETICS
  • 2008-12. catmap: Case-control And TDT Meta-Analysis Package in BMC BIOINFORMATICS
  • 2001-11. Replication validity of genetic association studies in NATURE GENETICS
  • 2002-12. Biophysical properties of heteromultimeric erg K+ channels in PFLÜGERS ARCHIV - EUROPEAN JOURNAL OF PHYSIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/nm.1962

    DOI

    http://dx.doi.org/10.1038/nm.1962

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033743372

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19412172


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cerebral Cortex", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cognition", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "ERG1 Potassium Channel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ether-A-Go-Go Potassium Channels", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "European Continental Ancestry Group", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurons", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Primates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Schizophrenia", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huffaker", 
            "givenName": "Stephen J", 
            "id": "sg:person.015564743577.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015564743577.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Jingshan", 
            "id": "sg:person.0607673017.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607673017.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nicodemus", 
            "givenName": "Kristin K", 
            "id": "sg:person.01203605077.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203605077.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sambataro", 
            "givenName": "Fabio", 
            "id": "sg:person.01301505757.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301505757.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Neural Development and Plasticity, National Institute of Child Health and Development, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yang", 
            "givenName": "Feng", 
            "id": "sg:person.0777167575.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777167575.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mattay", 
            "givenName": "Venkata", 
            "id": "sg:person.012042065617.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012042065617.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lipska", 
            "givenName": "Barbara K", 
            "id": "sg:person.01254443520.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254443520.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hyde", 
            "givenName": "Thomas M", 
            "id": "sg:person.01322556720.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322556720.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "Jian", 
            "id": "sg:person.0652145117.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652145117.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rujescu", 
            "givenName": "Dan", 
            "id": "sg:person.0733662425.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733662425.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Ludwig Maximilian University of Munich", 
              "id": "https://www.grid.ac/institutes/grid.5252.0", 
              "name": [
                "Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Giegling", 
            "givenName": "Ina", 
            "id": "sg:person.01327771662.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327771662.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yerevan State Medical University", 
              "id": "https://www.grid.ac/institutes/grid.427559.8", 
              "name": [
                "Department of Psychiatry and Medical Psychology, Yerevan State Medical University, Health Ministry of Armenian, Yerevan, Armenia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mayilyan", 
            "givenName": "Karine", 
            "id": "sg:person.01150121071.46", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150121071.46"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Proust", 
            "givenName": "Morgan J", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Yerevan State Medical University", 
              "id": "https://www.grid.ac/institutes/grid.427559.8", 
              "name": [
                "Department of Psychiatry and Medical Psychology, Yerevan State Medical University, Health Ministry of Armenian, Yerevan, Armenia."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soghoyan", 
            "givenName": "Armen", 
            "id": "sg:person.01151277673.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151277673.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bari Aldo Moro", 
              "id": "https://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Caforio", 
            "givenName": "Grazia", 
            "id": "sg:person.01133650463.07", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133650463.07"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Callicott", 
            "givenName": "Joseph H", 
            "id": "sg:person.013756335637.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013756335637.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Bari Aldo Moro", 
              "id": "https://www.grid.ac/institutes/grid.7644.1", 
              "name": [
                "Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bertolino", 
            "givenName": "Alessandro", 
            "id": "sg:person.01067234016.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067234016.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meyer-Lindenberg", 
            "givenName": "Andreas", 
            "id": "sg:person.0700662635.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700662635.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA.", 
                "Section on Neural Development and Plasticity, National Institute of Child Health and Development, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Jay", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Section on Neural Development and Plasticity, National Institute of Child Health and Development, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ji", 
            "givenName": "Yuanyuan", 
            "id": "sg:person.0601521764.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601521764.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Egan", 
            "givenName": "Michael F", 
            "id": "sg:person.0673135654.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673135654.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Goldberg", 
            "givenName": "Terry E", 
            "id": "sg:person.01234200154.52", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234200154.52"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kleinman", 
            "givenName": "Joel E", 
            "id": "sg:person.01243353647.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243353647.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Child Health and Human Development", 
              "id": "https://www.grid.ac/institutes/grid.420089.7", 
              "name": [
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA.", 
                "Section on Neural Development and Plasticity, National Institute of Child Health and Development, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lu", 
            "givenName": "Bai", 
            "id": "sg:person.01146146354.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146146354.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute of Mental Health", 
              "id": "https://www.grid.ac/institutes/grid.416868.5", 
              "name": [
                "Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.", 
                "Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weinberger", 
            "givenName": "Daniel R", 
            "id": "sg:person.013001662311.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013001662311.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.biopsych.2006.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001909765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004487596", 
              "https://doi.org/10.1186/1471-2105-9-130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-9-130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004487596", 
              "https://doi.org/10.1186/1471-2105-9-130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004556449", 
              "https://doi.org/10.1038/nature05911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.8.3438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009152437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00424-002-0936-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009382616", 
              "https://doi.org/10.1007/s00424-002-0936-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btl657", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011699815"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-2999(02)02074-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011853869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.2136650100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011943873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013279900", 
              "https://doi.org/10.1038/nature04710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013279900", 
              "https://doi.org/10.1038/nature04710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04710", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013279900", 
              "https://doi.org/10.1038/nature04710"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3223(01)01133-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015099756"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3223(01)01252-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015321565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cercor/10.11.1078", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016615261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/schbul/sbj058", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017296317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018485980", 
              "https://doi.org/10.1038/nn1014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018485980", 
              "https://doi.org/10.1038/nn1014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2004.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019797353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1192/bjp.182.2.171-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020269907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2008.25", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021812249", 
              "https://doi.org/10.1038/mp.2008.25"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022836479", 
              "https://doi.org/10.1038/ng.201"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5200625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026220336", 
              "https://doi.org/10.1038/sj.ejhg.5200625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5200625", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026220336", 
              "https://doi.org/10.1038/sj.ejhg.5200625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2007.05.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026691703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/447655a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027012183", 
              "https://doi.org/10.1038/447655a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1141634", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027547166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1670", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028111053", 
              "https://doi.org/10.1038/nn1670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-8628(19980710)81:4<275::aid-ajmg1>3.0.co;2-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029683630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ije/dym159", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030056335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033654326", 
              "https://doi.org/10.1038/nature02168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033654326", 
              "https://doi.org/10.1038/nature02168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/122.4.593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033940260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1128115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034069881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036139066", 
              "https://doi.org/10.1038/sj.mp.4001532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036139066", 
              "https://doi.org/10.1038/sj.mp.4001532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/hmg/ddl040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037664300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1469-7793.1997.313bn.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038169684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archpsyc.63.1.18", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039045151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1050-3862(98)00019-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041654045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db07-0856", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042455370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200008173430701", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042711114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.00104.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043769511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.20721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044947727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.20721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044947727"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045063649", 
              "https://doi.org/10.1038/ng749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045063649", 
              "https://doi.org/10.1038/ng749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81635-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047216924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0807322106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047772809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048407583", 
              "https://doi.org/10.1038/sj.mp.4001511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.mp.4001511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048407583", 
              "https://doi.org/10.1038/sj.mp.4001511"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5201227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048648094", 
              "https://doi.org/10.1038/sj.ejhg.5201227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ejhg.5201227", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048648094", 
              "https://doi.org/10.1038/sj.ejhg.5201227"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050097874", 
              "https://doi.org/10.1038/79866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/79866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050097874", 
              "https://doi.org/10.1038/79866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.00529.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050135886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.schres.2006.12.031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052269291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bmb/65.1.259", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053021785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053130114", 
              "https://doi.org/10.1038/ng.171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/303006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058610552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.289.5478.457", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062570363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.78.3.499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063340789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.157.8.1309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063493348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.160.4.709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063495231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/appi.ajp.161.3.490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063495801"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1176/jnp.14.4.377", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063511906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2202/1544-6115.1027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069289261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.19-18-08104.1999", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074518307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.2001.85.6.2590", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074829042"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.23-17-06690.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075324294"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-05", 
        "datePublishedReg": "2009-05-01", 
        "description": "Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related K(+) channel KCNH2 that modulates neuronal firing. KCNH2-3.1 messenger RNA levels are comparable to full-length KCNH2 (1A) levels in brain but three orders of magnitude lower in heart. In hippocampus from individuals with schizophrenia, KCNH2-3.1 expression is 2.5-fold greater than KCNH2-1A expression. A meta-analysis of five clinical data sets (367 families, 1,158 unrelated cases and 1,704 controls) shows association of single nucleotide polymorphisms in KCNH2 with schizophrenia. Risk-associated alleles predict lower intelligence quotient scores and speed of cognitive processing, altered memory-linked functional magnetic resonance imaging signals and increased KCNH2-3.1 mRNA levels in postmortem hippocampus. KCNH2-3.1 lacks a domain that is crucial for slow channel deactivation. Overexpression of KCNH2-3.1 in primary cortical neurons induces a rapidly deactivating K(+) current and a high-frequency, nonadapting firing pattern. These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/nm.1962", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2726104", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2721016", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726085", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726176", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2720998", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726640", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2721175", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726102", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2726641", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1113716", 
            "issn": [
              "1078-8956", 
              "1546-170X"
            ], 
            "name": "Nature Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "15"
          }
        ], 
        "name": "A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia", 
        "pagination": "509-518", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "a0be0baa151a7b6a2bf630dfc97da610bb9dcdef7849be94c3f778c1d9e28dde"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19412172"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9502015"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/nm.1962"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1033743372"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/nm.1962", 
          "https://app.dimensions.ai/details/publication/pub.1033743372"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T09:14", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47997_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/nm.1962"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.1962'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.1962'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.1962'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.1962'


     

    This table displays all metadata directly associated to this object as RDF triples.

    514 TRIPLES      21 PREDICATES      101 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/nm.1962 schema:about N09b5f65550db4a9e886053703f03bff1
    2 N67400eb5aa424230aaa89d5ce2e3c9c7
    3 N752bd48d1d0342a1804cac41f7d8d023
    4 Na165351a854640909f2b6ad4509f0db5
    5 Na1e588cfbe2c45d78b6fb72ee4ce03fc
    6 Nb457377af59e442aba19fd1f8409cf5c
    7 Nbfbc86c4af6a4b4ca0ccd2c9745d0390
    8 Ncc94857a218e4a23982243815f3dd703
    9 Ncd016b8b10fb4ccfb157df016b7aeb0a
    10 Ncf0631bfda594700b2727321d26360cb
    11 Ndca41bce72694c04b697f8917df837a8
    12 Nec20d53e8dbe4873bc76e75c1f08217d
    13 Nf614ecae133d43d5b27ecc0dcf991b35
    14 Nfb53864a4442430389998e5e8c29e180
    15 anzsrc-for:11
    16 anzsrc-for:1109
    17 schema:author N758936968bff40f3bd860ab57d7a606f
    18 schema:citation sg:pub.10.1007/s00424-002-0936-4
    19 sg:pub.10.1038/447655a
    20 sg:pub.10.1038/79866
    21 sg:pub.10.1038/mp.2008.25
    22 sg:pub.10.1038/nature02168
    23 sg:pub.10.1038/nature04710
    24 sg:pub.10.1038/nature05911
    25 sg:pub.10.1038/ng.171
    26 sg:pub.10.1038/ng.201
    27 sg:pub.10.1038/ng749
    28 sg:pub.10.1038/nn1014
    29 sg:pub.10.1038/nn1670
    30 sg:pub.10.1038/sj.ejhg.5200625
    31 sg:pub.10.1038/sj.ejhg.5201227
    32 sg:pub.10.1038/sj.mp.4001511
    33 sg:pub.10.1038/sj.mp.4001532
    34 sg:pub.10.1186/1471-2105-9-130
    35 https://doi.org/10.1001/archpsyc.63.1.18
    36 https://doi.org/10.1002/(sici)1096-8628(19980710)81:4<275::aid-ajmg1>3.0.co;2-t
    37 https://doi.org/10.1002/cne.20721
    38 https://doi.org/10.1016/j.biopsych.2006.06.002
    39 https://doi.org/10.1016/j.biopsych.2007.05.027
    40 https://doi.org/10.1016/j.schres.2006.12.031
    41 https://doi.org/10.1016/j.tins.2004.08.002
    42 https://doi.org/10.1016/s0006-3223(01)01133-7
    43 https://doi.org/10.1016/s0006-3223(01)01252-5
    44 https://doi.org/10.1016/s0014-2999(02)02074-5
    45 https://doi.org/10.1016/s0092-8674(00)81635-9
    46 https://doi.org/10.1016/s1050-3862(98)00019-9
    47 https://doi.org/10.1056/nejm200008173430701
    48 https://doi.org/10.1073/pnas.0807322106
    49 https://doi.org/10.1073/pnas.2136650100
    50 https://doi.org/10.1073/pnas.91.8.3438
    51 https://doi.org/10.1086/303006
    52 https://doi.org/10.1093/bioinformatics/btl657
    53 https://doi.org/10.1093/bmb/65.1.259
    54 https://doi.org/10.1093/brain/122.4.593
    55 https://doi.org/10.1093/cercor/10.11.1078
    56 https://doi.org/10.1093/hmg/ddl040
    57 https://doi.org/10.1093/ije/dym159
    58 https://doi.org/10.1093/schbul/sbj058
    59 https://doi.org/10.1111/j.1469-7793.1997.313bn.x
    60 https://doi.org/10.1126/science.1128115
    61 https://doi.org/10.1126/science.1141634
    62 https://doi.org/10.1126/science.289.5478.457
    63 https://doi.org/10.1152/jn.00104.2003
    64 https://doi.org/10.1152/jn.00529.2003
    65 https://doi.org/10.1152/jn.2001.85.6.2590
    66 https://doi.org/10.1161/01.res.78.3.499
    67 https://doi.org/10.1176/appi.ajp.157.8.1309
    68 https://doi.org/10.1176/appi.ajp.160.4.709
    69 https://doi.org/10.1176/appi.ajp.161.3.490
    70 https://doi.org/10.1176/jnp.14.4.377
    71 https://doi.org/10.1192/bjp.182.2.171-a
    72 https://doi.org/10.1523/jneurosci.19-18-08104.1999
    73 https://doi.org/10.1523/jneurosci.23-17-06690.2003
    74 https://doi.org/10.2202/1544-6115.1027
    75 https://doi.org/10.2337/db07-0856
    76 schema:datePublished 2009-05
    77 schema:datePublishedReg 2009-05-01
    78 schema:description Organized neuronal firing is crucial for cortical processing and is disrupted in schizophrenia. Using rapid amplification of 5' complementary DNA ends in human brain, we identified a primate-specific isoform (3.1) of the ether-a-go-go-related K(+) channel KCNH2 that modulates neuronal firing. KCNH2-3.1 messenger RNA levels are comparable to full-length KCNH2 (1A) levels in brain but three orders of magnitude lower in heart. In hippocampus from individuals with schizophrenia, KCNH2-3.1 expression is 2.5-fold greater than KCNH2-1A expression. A meta-analysis of five clinical data sets (367 families, 1,158 unrelated cases and 1,704 controls) shows association of single nucleotide polymorphisms in KCNH2 with schizophrenia. Risk-associated alleles predict lower intelligence quotient scores and speed of cognitive processing, altered memory-linked functional magnetic resonance imaging signals and increased KCNH2-3.1 mRNA levels in postmortem hippocampus. KCNH2-3.1 lacks a domain that is crucial for slow channel deactivation. Overexpression of KCNH2-3.1 in primary cortical neurons induces a rapidly deactivating K(+) current and a high-frequency, nonadapting firing pattern. These results identify a previously undescribed KCNH2 channel isoform involved in cortical physiology, cognition and psychosis, providing a potential new therapeutic drug target.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree true
    82 schema:isPartOf N1500359e138c499989ed51c558dc7141
    83 Nf0cf578d29154440ba15fd9d815c1b06
    84 sg:journal.1113716
    85 schema:name A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia
    86 schema:pagination 509-518
    87 schema:productId N2d4698a032d94ad1bad4f0e2d89d7483
    88 N37dc1e68d98a4fb6802a7b63b70836fd
    89 N73eabf77d0224ea9b367681e3e878798
    90 N7b862faab351473bb7db6f7823e40d0f
    91 N874a814d5ff345b6bcf2ab98d40e9481
    92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033743372
    93 https://doi.org/10.1038/nm.1962
    94 schema:sdDatePublished 2019-04-11T09:14
    95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    96 schema:sdPublisher N797c9ba2c5c748faa1423f1be2e41cf9
    97 schema:url http://www.nature.com/articles/nm.1962
    98 sgo:license sg:explorer/license/
    99 sgo:sdDataset articles
    100 rdf:type schema:ScholarlyArticle
    101 N09b5f65550db4a9e886053703f03bff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Neurons
    103 rdf:type schema:DefinedTerm
    104 N0b693219c6c143c3ae12b2a5de8b3fab rdf:first sg:person.0652145117.72
    105 rdf:rest Nbd36be1b3b61484d9aa514b729cfead0
    106 N1500359e138c499989ed51c558dc7141 schema:issueNumber 5
    107 rdf:type schema:PublicationIssue
    108 N163bc3f09c3e4f11819d8de62a41c19b rdf:first sg:person.01203605077.08
    109 rdf:rest N56255595e8f54e5a9d4c704ff3e46d45
    110 N183acaf74f664b6dada9efa4d44547fe rdf:first sg:person.01243353647.06
    111 rdf:rest Na9616206e8b9474bac1c148815e57993
    112 N1b80dd42561a47b19fd219daf0c10e9f rdf:first sg:person.0607673017.83
    113 rdf:rest N163bc3f09c3e4f11819d8de62a41c19b
    114 N1d1f004d2f264fff8fc77b8147cae309 rdf:first sg:person.01234200154.52
    115 rdf:rest N183acaf74f664b6dada9efa4d44547fe
    116 N27e8b41cd4254dcf8fc7e17c470eb6e2 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    117 schema:familyName Chang
    118 schema:givenName Jay
    119 rdf:type schema:Person
    120 N2a779fd566ca41179e3e3bc663533e3d rdf:first sg:person.01151277673.32
    121 rdf:rest Nf690fe1aa199476cb82753842c18e657
    122 N2d4698a032d94ad1bad4f0e2d89d7483 schema:name readcube_id
    123 schema:value a0be0baa151a7b6a2bf630dfc97da610bb9dcdef7849be94c3f778c1d9e28dde
    124 rdf:type schema:PropertyValue
    125 N37dc1e68d98a4fb6802a7b63b70836fd schema:name dimensions_id
    126 schema:value pub.1033743372
    127 rdf:type schema:PropertyValue
    128 N56255595e8f54e5a9d4c704ff3e46d45 rdf:first sg:person.01301505757.63
    129 rdf:rest Nd889655ce7684596b02d0d75cbd24e35
    130 N597ab6d3cae54e6696e8949672c44fc1 rdf:first sg:person.0673135654.86
    131 rdf:rest N1d1f004d2f264fff8fc77b8147cae309
    132 N67400eb5aa424230aaa89d5ce2e3c9c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name European Continental Ancestry Group
    134 rdf:type schema:DefinedTerm
    135 N680c358284864661bd2165c6163a9afd rdf:first Ne767bcd08a82436493578f235ec76af2
    136 rdf:rest N2a779fd566ca41179e3e3bc663533e3d
    137 N708ccededee34b0c8a7fd4fe362cc7da rdf:first sg:person.013756335637.08
    138 rdf:rest N82f79d6e19e84bfda1cf20a02b4a2f29
    139 N73eabf77d0224ea9b367681e3e878798 schema:name doi
    140 schema:value 10.1038/nm.1962
    141 rdf:type schema:PropertyValue
    142 N752bd48d1d0342a1804cac41f7d8d023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Schizophrenia
    144 rdf:type schema:DefinedTerm
    145 N758936968bff40f3bd860ab57d7a606f rdf:first sg:person.015564743577.25
    146 rdf:rest N1b80dd42561a47b19fd219daf0c10e9f
    147 N797c9ba2c5c748faa1423f1be2e41cf9 schema:name Springer Nature - SN SciGraph project
    148 rdf:type schema:Organization
    149 N7b862faab351473bb7db6f7823e40d0f schema:name pubmed_id
    150 schema:value 19412172
    151 rdf:type schema:PropertyValue
    152 N814af09237ef444d838acee9dd272b43 rdf:first sg:person.01150121071.46
    153 rdf:rest N680c358284864661bd2165c6163a9afd
    154 N82f79d6e19e84bfda1cf20a02b4a2f29 rdf:first sg:person.01067234016.79
    155 rdf:rest Nddb3dc9d55ec4b97b9a39421a41b189c
    156 N835380ad836843ca86fe456a06d89f4b rdf:first sg:person.01322556720.38
    157 rdf:rest N0b693219c6c143c3ae12b2a5de8b3fab
    158 N874a814d5ff345b6bcf2ab98d40e9481 schema:name nlm_unique_id
    159 schema:value 9502015
    160 rdf:type schema:PropertyValue
    161 N9d4aa0db55ff4c26b444ef417fbeb0a9 rdf:first sg:person.01327771662.24
    162 rdf:rest N814af09237ef444d838acee9dd272b43
    163 Na165351a854640909f2b6ad4509f0db5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Ether-A-Go-Go Potassium Channels
    165 rdf:type schema:DefinedTerm
    166 Na1e588cfbe2c45d78b6fb72ee4ce03fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Cognition
    168 rdf:type schema:DefinedTerm
    169 Na9616206e8b9474bac1c148815e57993 rdf:first sg:person.01146146354.18
    170 rdf:rest Nb594093d14d44f6fa31b8ff265b48354
    171 Nb457377af59e442aba19fd1f8409cf5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Risk Factors
    173 rdf:type schema:DefinedTerm
    174 Nb594093d14d44f6fa31b8ff265b48354 rdf:first sg:person.013001662311.03
    175 rdf:rest rdf:nil
    176 Nb8810eeaffe441979d66bc4a0f3670d7 rdf:first sg:person.0601521764.64
    177 rdf:rest N597ab6d3cae54e6696e8949672c44fc1
    178 Nbd36be1b3b61484d9aa514b729cfead0 rdf:first sg:person.0733662425.46
    179 rdf:rest N9d4aa0db55ff4c26b444ef417fbeb0a9
    180 Nbfbc86c4af6a4b4ca0ccd2c9745d0390 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name ERG1 Potassium Channel
    182 rdf:type schema:DefinedTerm
    183 Nc8679ed48d984febad45b9d684437c6f rdf:first N27e8b41cd4254dcf8fc7e17c470eb6e2
    184 rdf:rest Nb8810eeaffe441979d66bc4a0f3670d7
    185 Ncc94857a218e4a23982243815f3dd703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Animals
    187 rdf:type schema:DefinedTerm
    188 Ncd016b8b10fb4ccfb157df016b7aeb0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Molecular Sequence Data
    190 rdf:type schema:DefinedTerm
    191 Ncf0631bfda594700b2727321d26360cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Humans
    193 rdf:type schema:DefinedTerm
    194 Nd889655ce7684596b02d0d75cbd24e35 rdf:first sg:person.0777167575.16
    195 rdf:rest Nea7f836cb64e40a785e2c091452f4abe
    196 Ndca41bce72694c04b697f8917df837a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Cerebral Cortex
    198 rdf:type schema:DefinedTerm
    199 Nddb3dc9d55ec4b97b9a39421a41b189c rdf:first sg:person.0700662635.66
    200 rdf:rest Nc8679ed48d984febad45b9d684437c6f
    201 Ne4594c63bcb441bcbd7e3d86d9c62bb2 rdf:first sg:person.01254443520.45
    202 rdf:rest N835380ad836843ca86fe456a06d89f4b
    203 Ne767bcd08a82436493578f235ec76af2 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    204 schema:familyName Proust
    205 schema:givenName Morgan J
    206 rdf:type schema:Person
    207 Nea7f836cb64e40a785e2c091452f4abe rdf:first sg:person.012042065617.89
    208 rdf:rest Ne4594c63bcb441bcbd7e3d86d9c62bb2
    209 Nec20d53e8dbe4873bc76e75c1f08217d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Gene Expression Regulation
    211 rdf:type schema:DefinedTerm
    212 Nf0cf578d29154440ba15fd9d815c1b06 schema:volumeNumber 15
    213 rdf:type schema:PublicationVolume
    214 Nf614ecae133d43d5b27ecc0dcf991b35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Primates
    216 rdf:type schema:DefinedTerm
    217 Nf690fe1aa199476cb82753842c18e657 rdf:first sg:person.01133650463.07
    218 rdf:rest N708ccededee34b0c8a7fd4fe362cc7da
    219 Nfb53864a4442430389998e5e8c29e180 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Polymorphism, Single Nucleotide
    221 rdf:type schema:DefinedTerm
    222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    223 schema:name Medical and Health Sciences
    224 rdf:type schema:DefinedTerm
    225 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    226 schema:name Neurosciences
    227 rdf:type schema:DefinedTerm
    228 sg:grant.2720998 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    229 rdf:type schema:MonetaryGrant
    230 sg:grant.2721016 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    231 rdf:type schema:MonetaryGrant
    232 sg:grant.2721175 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    233 rdf:type schema:MonetaryGrant
    234 sg:grant.2726085 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    235 rdf:type schema:MonetaryGrant
    236 sg:grant.2726102 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    237 rdf:type schema:MonetaryGrant
    238 sg:grant.2726104 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    239 rdf:type schema:MonetaryGrant
    240 sg:grant.2726176 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    241 rdf:type schema:MonetaryGrant
    242 sg:grant.2726640 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    243 rdf:type schema:MonetaryGrant
    244 sg:grant.2726641 http://pending.schema.org/fundedItem sg:pub.10.1038/nm.1962
    245 rdf:type schema:MonetaryGrant
    246 sg:journal.1113716 schema:issn 1078-8956
    247 1546-170X
    248 schema:name Nature Medicine
    249 rdf:type schema:Periodical
    250 sg:person.01067234016.79 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
    251 schema:familyName Bertolino
    252 schema:givenName Alessandro
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067234016.79
    254 rdf:type schema:Person
    255 sg:person.01133650463.07 schema:affiliation https://www.grid.ac/institutes/grid.7644.1
    256 schema:familyName Caforio
    257 schema:givenName Grazia
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133650463.07
    259 rdf:type schema:Person
    260 sg:person.01146146354.18 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    261 schema:familyName Lu
    262 schema:givenName Bai
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146146354.18
    264 rdf:type schema:Person
    265 sg:person.01150121071.46 schema:affiliation https://www.grid.ac/institutes/grid.427559.8
    266 schema:familyName Mayilyan
    267 schema:givenName Karine
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150121071.46
    269 rdf:type schema:Person
    270 sg:person.01151277673.32 schema:affiliation https://www.grid.ac/institutes/grid.427559.8
    271 schema:familyName Soghoyan
    272 schema:givenName Armen
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151277673.32
    274 rdf:type schema:Person
    275 sg:person.01203605077.08 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    276 schema:familyName Nicodemus
    277 schema:givenName Kristin K
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203605077.08
    279 rdf:type schema:Person
    280 sg:person.012042065617.89 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    281 schema:familyName Mattay
    282 schema:givenName Venkata
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012042065617.89
    284 rdf:type schema:Person
    285 sg:person.01234200154.52 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    286 schema:familyName Goldberg
    287 schema:givenName Terry E
    288 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234200154.52
    289 rdf:type schema:Person
    290 sg:person.01243353647.06 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    291 schema:familyName Kleinman
    292 schema:givenName Joel E
    293 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243353647.06
    294 rdf:type schema:Person
    295 sg:person.01254443520.45 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    296 schema:familyName Lipska
    297 schema:givenName Barbara K
    298 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254443520.45
    299 rdf:type schema:Person
    300 sg:person.013001662311.03 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    301 schema:familyName Weinberger
    302 schema:givenName Daniel R
    303 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013001662311.03
    304 rdf:type schema:Person
    305 sg:person.01301505757.63 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    306 schema:familyName Sambataro
    307 schema:givenName Fabio
    308 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301505757.63
    309 rdf:type schema:Person
    310 sg:person.01322556720.38 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    311 schema:familyName Hyde
    312 schema:givenName Thomas M
    313 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322556720.38
    314 rdf:type schema:Person
    315 sg:person.01327771662.24 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    316 schema:familyName Giegling
    317 schema:givenName Ina
    318 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327771662.24
    319 rdf:type schema:Person
    320 sg:person.013756335637.08 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    321 schema:familyName Callicott
    322 schema:givenName Joseph H
    323 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013756335637.08
    324 rdf:type schema:Person
    325 sg:person.015564743577.25 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    326 schema:familyName Huffaker
    327 schema:givenName Stephen J
    328 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015564743577.25
    329 rdf:type schema:Person
    330 sg:person.0601521764.64 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    331 schema:familyName Ji
    332 schema:givenName Yuanyuan
    333 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601521764.64
    334 rdf:type schema:Person
    335 sg:person.0607673017.83 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    336 schema:familyName Chen
    337 schema:givenName Jingshan
    338 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607673017.83
    339 rdf:type schema:Person
    340 sg:person.0652145117.72 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    341 schema:familyName Song
    342 schema:givenName Jian
    343 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652145117.72
    344 rdf:type schema:Person
    345 sg:person.0673135654.86 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    346 schema:familyName Egan
    347 schema:givenName Michael F
    348 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673135654.86
    349 rdf:type schema:Person
    350 sg:person.0700662635.66 schema:affiliation https://www.grid.ac/institutes/grid.416868.5
    351 schema:familyName Meyer-Lindenberg
    352 schema:givenName Andreas
    353 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700662635.66
    354 rdf:type schema:Person
    355 sg:person.0733662425.46 schema:affiliation https://www.grid.ac/institutes/grid.5252.0
    356 schema:familyName Rujescu
    357 schema:givenName Dan
    358 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733662425.46
    359 rdf:type schema:Person
    360 sg:person.0777167575.16 schema:affiliation https://www.grid.ac/institutes/grid.420089.7
    361 schema:familyName Yang
    362 schema:givenName Feng
    363 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777167575.16
    364 rdf:type schema:Person
    365 sg:pub.10.1007/s00424-002-0936-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009382616
    366 https://doi.org/10.1007/s00424-002-0936-4
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1038/447655a schema:sameAs https://app.dimensions.ai/details/publication/pub.1027012183
    369 https://doi.org/10.1038/447655a
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1038/79866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050097874
    372 https://doi.org/10.1038/79866
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1038/mp.2008.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021812249
    375 https://doi.org/10.1038/mp.2008.25
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1038/nature02168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033654326
    378 https://doi.org/10.1038/nature02168
    379 rdf:type schema:CreativeWork
    380 sg:pub.10.1038/nature04710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013279900
    381 https://doi.org/10.1038/nature04710
    382 rdf:type schema:CreativeWork
    383 sg:pub.10.1038/nature05911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004556449
    384 https://doi.org/10.1038/nature05911
    385 rdf:type schema:CreativeWork
    386 sg:pub.10.1038/ng.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053130114
    387 https://doi.org/10.1038/ng.171
    388 rdf:type schema:CreativeWork
    389 sg:pub.10.1038/ng.201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022836479
    390 https://doi.org/10.1038/ng.201
    391 rdf:type schema:CreativeWork
    392 sg:pub.10.1038/ng749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045063649
    393 https://doi.org/10.1038/ng749
    394 rdf:type schema:CreativeWork
    395 sg:pub.10.1038/nn1014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018485980
    396 https://doi.org/10.1038/nn1014
    397 rdf:type schema:CreativeWork
    398 sg:pub.10.1038/nn1670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028111053
    399 https://doi.org/10.1038/nn1670
    400 rdf:type schema:CreativeWork
    401 sg:pub.10.1038/sj.ejhg.5200625 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026220336
    402 https://doi.org/10.1038/sj.ejhg.5200625
    403 rdf:type schema:CreativeWork
    404 sg:pub.10.1038/sj.ejhg.5201227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048648094
    405 https://doi.org/10.1038/sj.ejhg.5201227
    406 rdf:type schema:CreativeWork
    407 sg:pub.10.1038/sj.mp.4001511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048407583
    408 https://doi.org/10.1038/sj.mp.4001511
    409 rdf:type schema:CreativeWork
    410 sg:pub.10.1038/sj.mp.4001532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036139066
    411 https://doi.org/10.1038/sj.mp.4001532
    412 rdf:type schema:CreativeWork
    413 sg:pub.10.1186/1471-2105-9-130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004487596
    414 https://doi.org/10.1186/1471-2105-9-130
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1001/archpsyc.63.1.18 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039045151
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1002/(sici)1096-8628(19980710)81:4<275::aid-ajmg1>3.0.co;2-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1029683630
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1002/cne.20721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044947727
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.biopsych.2006.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001909765
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/j.biopsych.2007.05.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026691703
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/j.schres.2006.12.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052269291
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1016/j.tins.2004.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019797353
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1016/s0006-3223(01)01133-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015099756
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1016/s0006-3223(01)01252-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015321565
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1016/s0014-2999(02)02074-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853869
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/s0092-8674(00)81635-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047216924
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/s1050-3862(98)00019-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041654045
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1056/nejm200008173430701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042711114
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1073/pnas.0807322106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047772809
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1073/pnas.2136650100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011943873
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1073/pnas.91.8.3438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009152437
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1086/303006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058610552
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1093/bioinformatics/btl657 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011699815
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1093/bmb/65.1.259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053021785
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1093/brain/122.4.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033940260
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1093/cercor/10.11.1078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016615261
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1093/hmg/ddl040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037664300
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1093/ije/dym159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030056335
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1093/schbul/sbj058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017296317
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1111/j.1469-7793.1997.313bn.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038169684
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1126/science.1128115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034069881
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1126/science.1141634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027547166
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1126/science.289.5478.457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062570363
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1152/jn.00104.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043769511
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1152/jn.00529.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050135886
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1152/jn.2001.85.6.2590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074829042
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1161/01.res.78.3.499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063340789
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1176/appi.ajp.157.8.1309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063493348
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1176/appi.ajp.160.4.709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063495231
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1176/appi.ajp.161.3.490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063495801
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1176/jnp.14.4.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063511906
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1192/bjp.182.2.171-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1020269907
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1523/jneurosci.19-18-08104.1999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074518307
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1523/jneurosci.23-17-06690.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075324294
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.2202/1544-6115.1027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069289261
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.2337/db07-0856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042455370
    497 rdf:type schema:CreativeWork
    498 https://www.grid.ac/institutes/grid.416868.5 schema:alternateName National Institute of Mental Health
    499 schema:name Clinical Brain Disorders Branch, National Institute of Mental Health (NIMH), Bethesda, Maryland, USA.
    500 Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA.
    501 rdf:type schema:Organization
    502 https://www.grid.ac/institutes/grid.420089.7 schema:alternateName National Institute of Child Health and Human Development
    503 schema:name Genes, Cognition and Psychosis Program, NIMH, Bethesda, Maryland, USA.
    504 Section on Neural Development and Plasticity, National Institute of Child Health and Development, Bethesda, Maryland, USA.
    505 rdf:type schema:Organization
    506 https://www.grid.ac/institutes/grid.427559.8 schema:alternateName Yerevan State Medical University
    507 schema:name Department of Psychiatry and Medical Psychology, Yerevan State Medical University, Health Ministry of Armenian, Yerevan, Armenia.
    508 rdf:type schema:Organization
    509 https://www.grid.ac/institutes/grid.5252.0 schema:alternateName Ludwig Maximilian University of Munich
    510 schema:name Molecular and Clinical Neurobiology, Department of Psychiatry, Ludwig Maximilians University, Munich, Germany.
    511 rdf:type schema:Organization
    512 https://www.grid.ac/institutes/grid.7644.1 schema:alternateName University of Bari Aldo Moro
    513 schema:name Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy.
    514 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...