Chromosome instability is common in human cleavage-stage embryos View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-05

AUTHORS

Evelyne Vanneste, Thierry Voet, Cédric Le Caignec, Michèle Ampe, Peter Konings, Cindy Melotte, Sophie Debrock, Mustapha Amyere, Miikka Vikkula, Frans Schuit, Jean-Pierre Fryns, Geert Verbeke, Thomas D'Hooghe, Yves Moreau, Joris R Vermeesch

ABSTRACT

Chromosome instability is a hallmark of tumorigenesis. This study establishes that chromosome instability is also common during early human embryogenesis. A new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells. This revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles. This explains the low human fecundity and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders. More... »

PAGES

577-583

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.1924

DOI

http://dx.doi.org/10.1038/nm.1924

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013820464

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19396175


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aneuploidy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blastomeres", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomal Instability", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryo, Mammalian", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fertilization in Vitro", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Loss of Heterozygosity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Center for Human Genetics, K.U.Leuven, Leuven, Belgium.", 
            "Leuven University Fertility Center, University Hospital Gasthuisberg, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vanneste", 
        "givenName": "Evelyne", 
        "id": "sg:person.01107407422.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107407422.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Center for Human Genetics, K.U.Leuven, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voet", 
        "givenName": "Thierry", 
        "id": "sg:person.01026626365.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026626365.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nantes", 
          "id": "https://www.grid.ac/institutes/grid.277151.7", 
          "name": [
            "Center for Human Genetics, K.U.Leuven, Leuven, Belgium.", 
            "Centre Hospitalier Universitaire de Nantes, Service de G\u00e9n\u00e9tique Medicale, Nantes Cedex, France.", 
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, l'Institut du Thorax, Nantes, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Le Caignec", 
        "givenName": "C\u00e9dric", 
        "id": "sg:person.01072007737.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072007737.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Interuniversity Institute for Biostatistics and Statistical Bioinformatics, K.U.Leuven, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ampe", 
        "givenName": "Mich\u00e8le", 
        "id": "sg:person.0576151365.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576151365.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "ESAT-SISTA, K.U.Leuven, Heverlee, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Konings", 
        "givenName": "Peter", 
        "id": "sg:person.01155522622.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155522622.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Center for Human Genetics, K.U.Leuven, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Melotte", 
        "givenName": "Cindy", 
        "id": "sg:person.0740066342.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740066342.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Leuven University Fertility Center, University Hospital Gasthuisberg, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Debrock", 
        "givenName": "Sophie", 
        "id": "sg:person.01245242111.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245242111.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "de Duve Institute", 
          "id": "https://www.grid.ac/institutes/grid.16549.3f", 
          "name": [
            "de Duve Institute, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amyere", 
        "givenName": "Mustapha", 
        "id": "sg:person.01365755655.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365755655.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "de Duve Institute", 
          "id": "https://www.grid.ac/institutes/grid.16549.3f", 
          "name": [
            "de Duve Institute, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vikkula", 
        "givenName": "Miikka", 
        "id": "sg:person.01123331524.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123331524.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Molecular Cell Biology, Gene Expression Group, University Hospital Gasthuisberg, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schuit", 
        "givenName": "Frans", 
        "id": "sg:person.0736472232.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736472232.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Center for Human Genetics, K.U.Leuven, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fryns", 
        "givenName": "Jean-Pierre", 
        "id": "sg:person.011400630617.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011400630617.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Interuniversity Institute for Biostatistics and Statistical Bioinformatics, K.U.Leuven, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verbeke", 
        "givenName": "Geert", 
        "id": "sg:person.0665273673.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665273673.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universitaire Ziekenhuizen Leuven", 
          "id": "https://www.grid.ac/institutes/grid.410569.f", 
          "name": [
            "Leuven University Fertility Center, University Hospital Gasthuisberg, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "D'Hooghe", 
        "givenName": "Thomas", 
        "id": "sg:person.0633731256.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633731256.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "ESAT-SISTA, K.U.Leuven, Heverlee, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Moreau", 
        "givenName": "Yves", 
        "id": "sg:person.01150150205.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150150205.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KU Leuven", 
          "id": "https://www.grid.ac/institutes/grid.5596.f", 
          "name": [
            "Center for Human Genetics, K.U.Leuven, Leuven, Belgium."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vermeesch", 
        "givenName": "Joris R", 
        "id": "sg:person.0650122077.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650122077.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/humupd/8.4.333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000511093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.2007.054007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007612603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.1411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009429784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.1411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009429784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.957", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009557179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dei291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009655337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dei291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009655337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/17.1.325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011717337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl1030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012191095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012218108", 
          "https://doi.org/10.1038/nature03099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012218108", 
          "https://doi.org/10.1038/nature03099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dem412", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012377927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.1230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012996543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pd.1230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012996543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2005.04.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013136760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2005.04.068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013136760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016489846", 
          "https://doi.org/10.1038/sj.ejhg.5200669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5200669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016489846", 
          "https://doi.org/10.1038/sj.ejhg.5200669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35020592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017226982", 
          "https://doi.org/10.1038/35020592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35020592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017226982", 
          "https://doi.org/10.1038/35020592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0700631104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019133476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dem354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027242049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tig.2007.11.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028304774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000086894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029793223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000086894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029793223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/deg015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029927630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030770649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2005.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030770649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/dem424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030837697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/386623a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036879517", 
          "https://doi.org/10.1038/386623a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl336", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037030378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0000558", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039728985"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.6522707", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042731982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/deh536", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043303930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/332459a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045757747", 
          "https://doi.org/10.1038/332459a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/6.11.1055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046213470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/humrep/12.4.780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048273525"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0001306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048854583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddg231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049522303"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1096-8628(19990129)82:3<265::aid-ajmg14>3.0.co;2-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050687982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:chro.0000036594.38997.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050734211", 
          "https://doi.org/10.1023/b:chro.0000036594.38997.59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jmg.38.8.497", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050900150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molehr/gam087", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052780115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajhg.2007.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053032114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004399900225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054516669", 
          "https://doi.org/10.1007/s004399900225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004399900225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054516669", 
          "https://doi.org/10.1007/s004399900225"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-05", 
    "datePublishedReg": "2009-05-01", 
    "description": "Chromosome instability is a hallmark of tumorigenesis. This study establishes that chromosome instability is also common during early human embryogenesis. A new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells. This revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles. This explains the low human fecundity and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/nm.1924", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1113716", 
        "issn": [
          "1078-8956", 
          "1546-170X"
        ], 
        "name": "Nature Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "Chromosome instability is common in human cleavage-stage embryos", 
    "pagination": "577-583", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "41d66b9d4a278bbb020b3c63edbfa0f864d6e4cfd63c2aee43d4dc3ac21c681a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19396175"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9502015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/nm.1924"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013820464"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/nm.1924", 
      "https://app.dimensions.ai/details/publication/pub.1013820464"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000338_0000000338/records_47995_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/nm.1924"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/nm.1924'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/nm.1924'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/nm.1924'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/nm.1924'


 

This table displays all metadata directly associated to this object as RDF triples.

349 TRIPLES      21 PREDICATES      78 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/nm.1924 schema:about N030e4eb6c2ab483ba28f2eb07dddc6ea
2 N193c7914de1140e38f34bd0faab02099
3 N1ef1142679144e8490dbcfb755add46d
4 N24705d87cace4a4093bd58c799d785c0
5 N38323fdd33634aac86b29cbe74af7026
6 N75ab5ad46a7d4ecf9703500cc230d72e
7 N7ab6e93c9bfa46daa6c79ae946baa6e9
8 Na06c467ba2c94b5396d40d61091017bb
9 Na2fd23fadbfb43e4bb698ccb9dd75f28
10 Na4d7b5eb493844b5bde81e2c8af113e2
11 Nd639a62ee587476e8358959f19c32745
12 Ne40bca9a067841f1a521acbbd904aa28
13 Nea730c126a3a42cab1b6e2a2922d2fb3
14 anzsrc-for:06
15 anzsrc-for:0604
16 schema:author N192447026e1b4684acb083b1cd9c35d2
17 schema:citation sg:pub.10.1007/s004399900225
18 sg:pub.10.1023/b:chro.0000036594.38997.59
19 sg:pub.10.1038/332459a0
20 sg:pub.10.1038/35020592
21 sg:pub.10.1038/386623a0
22 sg:pub.10.1038/nature03099
23 sg:pub.10.1038/sj.ejhg.5200669
24 https://doi.org/10.1002/(sici)1096-8628(19990129)82:3<265::aid-ajmg14>3.0.co;2-6
25 https://doi.org/10.1002/pd.1230
26 https://doi.org/10.1002/pd.1411
27 https://doi.org/10.1002/pd.957
28 https://doi.org/10.1016/j.ajhg.2007.11.009
29 https://doi.org/10.1016/j.fertnstert.2005.04.068
30 https://doi.org/10.1016/j.fertnstert.2005.06.025
31 https://doi.org/10.1016/j.tig.2007.11.006
32 https://doi.org/10.1073/pnas.0700631104
33 https://doi.org/10.1093/emboj/17.1.325
34 https://doi.org/10.1093/hmg/ddg231
35 https://doi.org/10.1093/humrep/12.4.780
36 https://doi.org/10.1093/humrep/deg015
37 https://doi.org/10.1093/humrep/deh536
38 https://doi.org/10.1093/humrep/dei291
39 https://doi.org/10.1093/humrep/dem354
40 https://doi.org/10.1093/humrep/dem412
41 https://doi.org/10.1093/humrep/dem424
42 https://doi.org/10.1093/humupd/8.4.333
43 https://doi.org/10.1093/molehr/6.11.1055
44 https://doi.org/10.1093/molehr/gam087
45 https://doi.org/10.1093/nar/gkl1030
46 https://doi.org/10.1093/nar/gkl336
47 https://doi.org/10.1101/gr.6522707
48 https://doi.org/10.1136/jmg.2007.054007
49 https://doi.org/10.1136/jmg.38.8.497
50 https://doi.org/10.1159/000086894
51 https://doi.org/10.1371/journal.pone.0000558
52 https://doi.org/10.1371/journal.pone.0001306
53 schema:datePublished 2009-05
54 schema:datePublishedReg 2009-05-01
55 schema:description Chromosome instability is a hallmark of tumorigenesis. This study establishes that chromosome instability is also common during early human embryogenesis. A new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells. This revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles. This explains the low human fecundity and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders.
56 schema:genre research_article
57 schema:inLanguage en
58 schema:isAccessibleForFree false
59 schema:isPartOf N3a4865a8a9644eedbcdc1cd196b0053c
60 Nb83d2cc89ed644cebaed8848bd06e978
61 sg:journal.1113716
62 schema:name Chromosome instability is common in human cleavage-stage embryos
63 schema:pagination 577-583
64 schema:productId N07810e680a304812a121a95159120894
65 N4fddc2084d15427aaadf9766985078ef
66 Nbd52c6484ecd413e9a66853c16f500db
67 Nbdf3bcc2b140496baa40850162ad4b49
68 Nc8d0fa5fb1d249fca1f9b63c3c4d2729
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013820464
70 https://doi.org/10.1038/nm.1924
71 schema:sdDatePublished 2019-04-11T09:14
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N9e55571030764438bfd444fe53eb2312
74 schema:url http://www.nature.com/articles/nm.1924
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N030e4eb6c2ab483ba28f2eb07dddc6ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Adult
80 rdf:type schema:DefinedTerm
81 N07810e680a304812a121a95159120894 schema:name doi
82 schema:value 10.1038/nm.1924
83 rdf:type schema:PropertyValue
84 N09127a463436404596ddc5ffcb0936ca rdf:first sg:person.01026626365.10
85 rdf:rest Ne3a4027407b94adcb0edbae98251bc2a
86 N192447026e1b4684acb083b1cd9c35d2 rdf:first sg:person.01107407422.45
87 rdf:rest N09127a463436404596ddc5ffcb0936ca
88 N193c7914de1140e38f34bd0faab02099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Humans
90 rdf:type schema:DefinedTerm
91 N1ef1142679144e8490dbcfb755add46d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name In Situ Hybridization, Fluorescence
93 rdf:type schema:DefinedTerm
94 N24705d87cace4a4093bd58c799d785c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Aneuploidy
96 rdf:type schema:DefinedTerm
97 N3361f8e9e98a4fb48e4a3088e6a9a59f rdf:first sg:person.0650122077.36
98 rdf:rest rdf:nil
99 N38323fdd33634aac86b29cbe74af7026 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Polymorphism, Single Nucleotide
101 rdf:type schema:DefinedTerm
102 N3a4865a8a9644eedbcdc1cd196b0053c schema:issueNumber 5
103 rdf:type schema:PublicationIssue
104 N463cc96e1c7d41058745d64b53aecdca rdf:first sg:person.0665273673.62
105 rdf:rest Nbf9bbff938ad4b1b88d1d50d904dd75f
106 N4fddc2084d15427aaadf9766985078ef schema:name dimensions_id
107 schema:value pub.1013820464
108 rdf:type schema:PropertyValue
109 N5fabbd3678f94469baf6b8b0bedef9f5 rdf:first sg:person.01155522622.89
110 rdf:rest N69fd59e5db1f490eae2f3ef0805f8d9b
111 N69fd59e5db1f490eae2f3ef0805f8d9b rdf:first sg:person.0740066342.50
112 rdf:rest Nc0bc072728494096b708cfe987f077f4
113 N75ab5ad46a7d4ecf9703500cc230d72e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Chromosomal Instability
115 rdf:type schema:DefinedTerm
116 N79acb288dd194e3d8797e1e8e185b384 rdf:first sg:person.01150150205.35
117 rdf:rest N3361f8e9e98a4fb48e4a3088e6a9a59f
118 N7ab6e93c9bfa46daa6c79ae946baa6e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Female
120 rdf:type schema:DefinedTerm
121 N9e55571030764438bfd444fe53eb2312 schema:name Springer Nature - SN SciGraph project
122 rdf:type schema:Organization
123 Na06c467ba2c94b5396d40d61091017bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Embryo, Mammalian
125 rdf:type schema:DefinedTerm
126 Na2fd23fadbfb43e4bb698ccb9dd75f28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Fertilization in Vitro
128 rdf:type schema:DefinedTerm
129 Na4d7b5eb493844b5bde81e2c8af113e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Oligonucleotide Array Sequence Analysis
131 rdf:type schema:DefinedTerm
132 Na5183fb33fc74329b70f48a56fafc732 rdf:first sg:person.011400630617.09
133 rdf:rest N463cc96e1c7d41058745d64b53aecdca
134 Nb83d2cc89ed644cebaed8848bd06e978 schema:volumeNumber 15
135 rdf:type schema:PublicationVolume
136 Nbd52c6484ecd413e9a66853c16f500db schema:name nlm_unique_id
137 schema:value 9502015
138 rdf:type schema:PropertyValue
139 Nbdf3bcc2b140496baa40850162ad4b49 schema:name pubmed_id
140 schema:value 19396175
141 rdf:type schema:PropertyValue
142 Nbf9bbff938ad4b1b88d1d50d904dd75f rdf:first sg:person.0633731256.36
143 rdf:rest N79acb288dd194e3d8797e1e8e185b384
144 Nc0bc072728494096b708cfe987f077f4 rdf:first sg:person.01245242111.14
145 rdf:rest Nd076130bc46747f6b51d93de70e8274e
146 Nc1be2758adf14a239b722b1760b84f75 rdf:first sg:person.0576151365.98
147 rdf:rest N5fabbd3678f94469baf6b8b0bedef9f5
148 Nc8d0fa5fb1d249fca1f9b63c3c4d2729 schema:name readcube_id
149 schema:value 41d66b9d4a278bbb020b3c63edbfa0f864d6e4cfd63c2aee43d4dc3ac21c681a
150 rdf:type schema:PropertyValue
151 Nd05511b09f8e4f10bc57ba0a77deb6f2 rdf:first sg:person.01123331524.12
152 rdf:rest Ndbbf66c7be7946feae10baddf079b232
153 Nd076130bc46747f6b51d93de70e8274e rdf:first sg:person.01365755655.34
154 rdf:rest Nd05511b09f8e4f10bc57ba0a77deb6f2
155 Nd639a62ee587476e8358959f19c32745 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Pregnancy
157 rdf:type schema:DefinedTerm
158 Ndbbf66c7be7946feae10baddf079b232 rdf:first sg:person.0736472232.86
159 rdf:rest Na5183fb33fc74329b70f48a56fafc732
160 Ne3a4027407b94adcb0edbae98251bc2a rdf:first sg:person.01072007737.03
161 rdf:rest Nc1be2758adf14a239b722b1760b84f75
162 Ne40bca9a067841f1a521acbbd904aa28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Loss of Heterozygosity
164 rdf:type schema:DefinedTerm
165 Nea730c126a3a42cab1b6e2a2922d2fb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Blastomeres
167 rdf:type schema:DefinedTerm
168 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
169 schema:name Biological Sciences
170 rdf:type schema:DefinedTerm
171 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
172 schema:name Genetics
173 rdf:type schema:DefinedTerm
174 sg:journal.1113716 schema:issn 1078-8956
175 1546-170X
176 schema:name Nature Medicine
177 rdf:type schema:Periodical
178 sg:person.01026626365.10 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
179 schema:familyName Voet
180 schema:givenName Thierry
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026626365.10
182 rdf:type schema:Person
183 sg:person.01072007737.03 schema:affiliation https://www.grid.ac/institutes/grid.277151.7
184 schema:familyName Le Caignec
185 schema:givenName Cédric
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072007737.03
187 rdf:type schema:Person
188 sg:person.01107407422.45 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
189 schema:familyName Vanneste
190 schema:givenName Evelyne
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107407422.45
192 rdf:type schema:Person
193 sg:person.01123331524.12 schema:affiliation https://www.grid.ac/institutes/grid.16549.3f
194 schema:familyName Vikkula
195 schema:givenName Miikka
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123331524.12
197 rdf:type schema:Person
198 sg:person.011400630617.09 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
199 schema:familyName Fryns
200 schema:givenName Jean-Pierre
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011400630617.09
202 rdf:type schema:Person
203 sg:person.01150150205.35 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
204 schema:familyName Moreau
205 schema:givenName Yves
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150150205.35
207 rdf:type schema:Person
208 sg:person.01155522622.89 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
209 schema:familyName Konings
210 schema:givenName Peter
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155522622.89
212 rdf:type schema:Person
213 sg:person.01245242111.14 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
214 schema:familyName Debrock
215 schema:givenName Sophie
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245242111.14
217 rdf:type schema:Person
218 sg:person.01365755655.34 schema:affiliation https://www.grid.ac/institutes/grid.16549.3f
219 schema:familyName Amyere
220 schema:givenName Mustapha
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365755655.34
222 rdf:type schema:Person
223 sg:person.0576151365.98 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
224 schema:familyName Ampe
225 schema:givenName Michèle
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576151365.98
227 rdf:type schema:Person
228 sg:person.0633731256.36 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
229 schema:familyName D'Hooghe
230 schema:givenName Thomas
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633731256.36
232 rdf:type schema:Person
233 sg:person.0650122077.36 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
234 schema:familyName Vermeesch
235 schema:givenName Joris R
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650122077.36
237 rdf:type schema:Person
238 sg:person.0665273673.62 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
239 schema:familyName Verbeke
240 schema:givenName Geert
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665273673.62
242 rdf:type schema:Person
243 sg:person.0736472232.86 schema:affiliation https://www.grid.ac/institutes/grid.410569.f
244 schema:familyName Schuit
245 schema:givenName Frans
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736472232.86
247 rdf:type schema:Person
248 sg:person.0740066342.50 schema:affiliation https://www.grid.ac/institutes/grid.5596.f
249 schema:familyName Melotte
250 schema:givenName Cindy
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740066342.50
252 rdf:type schema:Person
253 sg:pub.10.1007/s004399900225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054516669
254 https://doi.org/10.1007/s004399900225
255 rdf:type schema:CreativeWork
256 sg:pub.10.1023/b:chro.0000036594.38997.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050734211
257 https://doi.org/10.1023/b:chro.0000036594.38997.59
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/332459a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045757747
260 https://doi.org/10.1038/332459a0
261 rdf:type schema:CreativeWork
262 sg:pub.10.1038/35020592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017226982
263 https://doi.org/10.1038/35020592
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/386623a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036879517
266 https://doi.org/10.1038/386623a0
267 rdf:type schema:CreativeWork
268 sg:pub.10.1038/nature03099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012218108
269 https://doi.org/10.1038/nature03099
270 rdf:type schema:CreativeWork
271 sg:pub.10.1038/sj.ejhg.5200669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016489846
272 https://doi.org/10.1038/sj.ejhg.5200669
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1002/(sici)1096-8628(19990129)82:3<265::aid-ajmg14>3.0.co;2-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050687982
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1002/pd.1230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012996543
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/pd.1411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009429784
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/pd.957 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009557179
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/j.ajhg.2007.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053032114
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/j.fertnstert.2005.04.068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013136760
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/j.fertnstert.2005.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030770649
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.tig.2007.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028304774
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1073/pnas.0700631104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019133476
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1093/emboj/17.1.325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011717337
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/hmg/ddg231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049522303
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1093/humrep/12.4.780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048273525
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1093/humrep/deg015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029927630
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1093/humrep/deh536 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043303930
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/humrep/dei291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009655337
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1093/humrep/dem354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027242049
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1093/humrep/dem412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012377927
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1093/humrep/dem424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030837697
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1093/humupd/8.4.333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000511093
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1093/molehr/6.11.1055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046213470
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1093/molehr/gam087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052780115
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1093/nar/gkl1030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012191095
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1093/nar/gkl336 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037030378
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1101/gr.6522707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042731982
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1136/jmg.2007.054007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007612603
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1136/jmg.38.8.497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050900150
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1159/000086894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029793223
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1371/journal.pone.0000558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039728985
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1371/journal.pone.0001306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048854583
331 rdf:type schema:CreativeWork
332 https://www.grid.ac/institutes/grid.16549.3f schema:alternateName de Duve Institute
333 schema:name de Duve Institute, Université Catholique de Louvain, Brussels, Belgium.
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.277151.7 schema:alternateName Centre Hospitalier Universitaire de Nantes
336 schema:name Center for Human Genetics, K.U.Leuven, Leuven, Belgium.
337 Centre Hospitalier Universitaire de Nantes, Service de Génétique Medicale, Nantes Cedex, France.
338 Institut National de la Santé et de la Recherche Médicale, l'Institut du Thorax, Nantes, France.
339 rdf:type schema:Organization
340 https://www.grid.ac/institutes/grid.410569.f schema:alternateName Universitaire Ziekenhuizen Leuven
341 schema:name Center for Human Genetics, K.U.Leuven, Leuven, Belgium.
342 Leuven University Fertility Center, University Hospital Gasthuisberg, Leuven, Belgium.
343 Molecular Cell Biology, Gene Expression Group, University Hospital Gasthuisberg, Leuven, Belgium.
344 rdf:type schema:Organization
345 https://www.grid.ac/institutes/grid.5596.f schema:alternateName KU Leuven
346 schema:name Center for Human Genetics, K.U.Leuven, Leuven, Belgium.
347 ESAT-SISTA, K.U.Leuven, Heverlee, Belgium.
348 Interuniversity Institute for Biostatistics and Statistical Bioinformatics, K.U.Leuven, Leuven, Belgium.
349 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...