The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2008-10-05

AUTHORS

Przemyslaw Sapieha, Mirna Sirinyan, David Hamel, Karine Zaniolo, Jean-Sébastien Joyal, Jang-Hyeon Cho, Jean-Claude Honoré, Elsa Kermorvant-Duchemin, Daya R Varma, Sophie Tremblay, Martin Leduc, Lenka Rihakova, Pierre Hardy, William H Klein, Xiuqian Mu, Orval Mamer, Pierre Lachapelle, Adriana Di Polo, Christian Beauséjour, Gregor Andelfinger, Grant Mitchell, Florian Sennlaub, Sylvain Chemtob

ABSTRACT

The mechanisms that control blood vessel formation are incompletely understood. Sylvain Chemtob and his colleagues now find that blood vessel formation in mouse and rat retinas is controlled by succinate generated during hypoxic and ischemic conditions. Succinate acting through its receptor, GPR91, on retinal ganglion neurons, triggers secretion of canonical proangiogenic factors and the formation of new blood vessels to reinstate adequate tissue supply. This work also identifies GPR91 as a potential therapeutic target for the treatment of ischemic retinopathies. More... »

PAGES

1067-1076

Journal

TITLE

Nature Medicine

ISSUE

10

VOLUME

14

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/nm.1873

DOI

http://dx.doi.org/10.1038/nm.1873

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005736593

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18836459


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