Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-08

AUTHORS

Christian A J Voßhenrich, Ana Cumano, Werner Müller, James P Di Santo, Paulo Vieira

ABSTRACT

Deletions of interleukin 7 (IL-7) or its receptor components permit fetal but not adult B cell development in mice. Mice deficient in IL-7 receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability of TSLP to support proliferation of fetal or adult precursor B cells. Only fetal-derived pro-B cells were able to respond to TSLP, although pre-B cells from both origins were TSLP-responsive. Fetal but not adult precursors generated a measurable B cell compartment in the absence of IL-7. The residual B cells found in IL-7R alpha-deficient mice required fetal liver kinase 2 (Flk-2) for their development. Thus, IL-7R alpha- and Flk-2-mediated signals account for the generation of almost all mouse B lymphocytes. More... »

PAGES

773-779

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni956

DOI

http://dx.doi.org/10.1038/ni956

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026574751

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12872121


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystatin C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cystatins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Interleukin-7", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thymus Gland", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Cologne", 
          "id": "https://www.grid.ac/institutes/grid.6190.e", 
          "name": [
            "Unit\u00e9 des Cytokines et D\u00e9veloppement Lympho\u00efde, INSERM Equipe, 101 Institut Pasteur, 75724 Paris, France.", 
            "Institute for Genetics, University of Cologne, 50931 Cologne, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vo\u00dfhenrich", 
        "givenName": "Christian A J", 
        "id": "sg:person.01176613253.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176613253.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 du D\u00e9veloppement des Lymphocytes, CNRS URA 1961, Institut Pasteur, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cumano", 
        "givenName": "Ana", 
        "id": "sg:person.0657136000.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657136000.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "GBF German Research Centre for Biotechnology", 
          "id": "https://www.grid.ac/institutes/grid.418123.d", 
          "name": [
            "Institute for Genetics, University of Cologne, 50931 Cologne, Germany.", 
            "Department of Experimental Immunology, GBF, 38124 Braunschweig, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Werner", 
        "id": "sg:person.01261504775.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261504775.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 des Cytokines et D\u00e9veloppement Lympho\u00efde, INSERM Equipe, 101 Institut Pasteur, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di Santo", 
        "givenName": "James P", 
        "id": "sg:person.01202454353.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202454353.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 du D\u00e9veloppement des Lymphocytes, CNRS URA 1961, Institut Pasteur, 75724 Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vieira", 
        "givenName": "Paulo", 
        "id": "sg:person.01077137664.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077137664.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1994.tb00665.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000451565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)90325-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001747744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.5.659", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001838754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90300-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002712862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.192.5.671", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004447169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90047-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004958298"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.189.2.319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009160305"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(92)90029-c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009230025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360225a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011545272", 
          "https://doi.org/10.1038/360225a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(03)00012-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015389230"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1521-4141(200006)30:6<1614::aid-immu1614>3.0.co;2-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015669673"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00419-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019142759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00386-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019304014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/76923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021044896", 
          "https://doi.org/10.1038/76923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/76923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021044896", 
          "https://doi.org/10.1038/76923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-5699(97)01203-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021963075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.173.5.1213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024075750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/3877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024424756", 
          "https://doi.org/10.1038/3877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/3877", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024424756", 
          "https://doi.org/10.1038/3877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044532302000702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025137679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1044532302000702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025137679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1995.tb00095.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025306014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.17.9797", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025945499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830260103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029658979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1998.tb01226.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031499494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.3.773", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034344973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2002.18904.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037856206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90167-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038314822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.5.1955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038785599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.2.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039826657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.194.8.1141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047570829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(01)00087-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048172167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.181.4.1519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052659065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.181.4.1519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052659065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20020784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052965351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8266077", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062653885"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074262632", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074553504", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.7.3288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075018042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078481993", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079044756", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082656383", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082960792", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083379021", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-08", 
    "datePublishedReg": "2003-08-01", 
    "description": "Deletions of interleukin 7 (IL-7) or its receptor components permit fetal but not adult B cell development in mice. Mice deficient in IL-7 receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability of TSLP to support proliferation of fetal or adult precursor B cells. Only fetal-derived pro-B cells were able to respond to TSLP, although pre-B cells from both origins were TSLP-responsive. Fetal but not adult precursors generated a measurable B cell compartment in the absence of IL-7. The residual B cells found in IL-7R alpha-deficient mice required fetal liver kinase 2 (Flk-2) for their development. Thus, IL-7R alpha- and Flk-2-mediated signals account for the generation of almost all mouse B lymphocytes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ni956", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1022778", 
        "issn": [
          "1529-2908", 
          "1529-2916"
        ], 
        "name": "Nature Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development", 
    "pagination": "773-779", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7e99eb53c9dbbce6540f7e940b7f017c93c850d5ff2bcab4a7ab0e650e24995b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12872121"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100941354"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ni956"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026574751"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ni956", 
      "https://app.dimensions.ai/details/publication/pub.1026574751"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:22", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87083_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ni956"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni956'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni956'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni956'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni956'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      79 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ni956 schema:about N1329e5f62219415c9bada62608f6fff8
2 N2fe5e7c8032b4d8eb575424b0438091a
3 N69201ba581cc4935a80ed64a10302115
4 N9c3a2f3ba06f4faba1881fe5d0d0b455
5 Na705e1bdc22e4136bff129122835a2a3
6 Na8319bd2ceaa4814bd56ea862c4f6ab2
7 Ndcf44aa3474640c8a4ec84c655d2dda2
8 Ne055c933f4ac43b5abb7edf9cecca251
9 Nf93163c44ac045c4a86d02d201afb17b
10 Nff794b6380a142869b354b135ad6569d
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N3cc4578871f748d19774bcbf630ec00f
14 schema:citation sg:pub.10.1038/360225a0
15 sg:pub.10.1038/3877
16 sg:pub.10.1038/76923
17 https://app.dimensions.ai/details/publication/pub.1074262632
18 https://app.dimensions.ai/details/publication/pub.1074553504
19 https://app.dimensions.ai/details/publication/pub.1078481993
20 https://app.dimensions.ai/details/publication/pub.1079044756
21 https://app.dimensions.ai/details/publication/pub.1082656383
22 https://app.dimensions.ai/details/publication/pub.1082960792
23 https://app.dimensions.ai/details/publication/pub.1083379021
24 https://doi.org/10.1002/1521-4141(200006)30:6<1614::aid-immu1614>3.0.co;2-i
25 https://doi.org/10.1002/eji.1830260103
26 https://doi.org/10.1016/0092-8674(90)90300-4
27 https://doi.org/10.1016/0092-8674(92)90029-c
28 https://doi.org/10.1016/0092-8674(93)90325-k
29 https://doi.org/10.1016/1074-7613(95)90047-0
30 https://doi.org/10.1016/1074-7613(95)90167-1
31 https://doi.org/10.1016/s0167-5699(97)01203-6
32 https://doi.org/10.1016/s0952-7915(03)00012-8
33 https://doi.org/10.1016/s0960-9822(01)00087-2
34 https://doi.org/10.1016/s1044532302000702
35 https://doi.org/10.1016/s1074-7613(02)00386-2
36 https://doi.org/10.1016/s1074-7613(02)00419-3
37 https://doi.org/10.1034/j.1600-065x.2002.18904.x
38 https://doi.org/10.1073/pnas.92.2.377
39 https://doi.org/10.1073/pnas.92.3.773
40 https://doi.org/10.1073/pnas.96.17.9797
41 https://doi.org/10.1084/jem.173.5.1213
42 https://doi.org/10.1084/jem.180.5.1955
43 https://doi.org/10.1084/jem.181.4.1519
44 https://doi.org/10.1084/jem.189.2.319
45 https://doi.org/10.1084/jem.192.5.659
46 https://doi.org/10.1084/jem.192.5.671
47 https://doi.org/10.1084/jem.194.8.1141
48 https://doi.org/10.1084/jem.20020784
49 https://doi.org/10.1111/j.1600-065x.1994.tb00665.x
50 https://doi.org/10.1111/j.1600-065x.1995.tb00095.x
51 https://doi.org/10.1111/j.1600-065x.1998.tb01226.x
52 https://doi.org/10.1126/science.8266077
53 https://doi.org/10.4049/jimmunol.168.7.3288
54 schema:datePublished 2003-08
55 schema:datePublishedReg 2003-08-01
56 schema:description Deletions of interleukin 7 (IL-7) or its receptor components permit fetal but not adult B cell development in mice. Mice deficient in IL-7 receptor alpha (IL-7R alpha) had 1% the number of B cells of controls and 10% that of mice deficient in the common gamma chain. As IL-7R alpha is also a receptor for thymic stromal-derived lymphopoietin (TSLP), we assayed the ability of TSLP to support proliferation of fetal or adult precursor B cells. Only fetal-derived pro-B cells were able to respond to TSLP, although pre-B cells from both origins were TSLP-responsive. Fetal but not adult precursors generated a measurable B cell compartment in the absence of IL-7. The residual B cells found in IL-7R alpha-deficient mice required fetal liver kinase 2 (Flk-2) for their development. Thus, IL-7R alpha- and Flk-2-mediated signals account for the generation of almost all mouse B lymphocytes.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree false
60 schema:isPartOf N177d2ff39e174521b4d799c1a5ac37fc
61 Nd9d604a0760e4404a0d37984566e64d5
62 sg:journal.1022778
63 schema:name Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development
64 schema:pagination 773-779
65 schema:productId N27ca011c336c4b73bebb3d0e97617503
66 N51663a7d12734f0ba0028dc3d1590c28
67 Nbfc176013eb64ce6a0a3f8f7f2811542
68 Nc4c705c857fe4d17bdcd0debad3bd807
69 Ne4ac481849b74ae989f410faaddf55a0
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026574751
71 https://doi.org/10.1038/ni956
72 schema:sdDatePublished 2019-04-11T12:22
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher Nf5123a13341345faa501558571a090ba
75 schema:url http://www.nature.com/articles/ni956
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N1329e5f62219415c9bada62608f6fff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Cytokines
81 rdf:type schema:DefinedTerm
82 N177d2ff39e174521b4d799c1a5ac37fc schema:issueNumber 8
83 rdf:type schema:PublicationIssue
84 N1950a5388e4f49bb8311ed18d5f2094e rdf:first sg:person.0657136000.86
85 rdf:rest N758a959590ca4724a9e2e0bdf52be27d
86 N27ca011c336c4b73bebb3d0e97617503 schema:name pubmed_id
87 schema:value 12872121
88 rdf:type schema:PropertyValue
89 N2fe5e7c8032b4d8eb575424b0438091a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Receptors, Interleukin-7
91 rdf:type schema:DefinedTerm
92 N3cc4578871f748d19774bcbf630ec00f rdf:first sg:person.01176613253.25
93 rdf:rest N1950a5388e4f49bb8311ed18d5f2094e
94 N51663a7d12734f0ba0028dc3d1590c28 schema:name dimensions_id
95 schema:value pub.1026574751
96 rdf:type schema:PropertyValue
97 N5406431fdd1646c4a4678efd3f28ae58 rdf:first sg:person.01077137664.28
98 rdf:rest rdf:nil
99 N69201ba581cc4935a80ed64a10302115 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N71a37a9fc7fc47eebb996e64712a6e64 rdf:first sg:person.01202454353.33
103 rdf:rest N5406431fdd1646c4a4678efd3f28ae58
104 N758a959590ca4724a9e2e0bdf52be27d rdf:first sg:person.01261504775.94
105 rdf:rest N71a37a9fc7fc47eebb996e64712a6e64
106 N9c3a2f3ba06f4faba1881fe5d0d0b455 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cystatins
108 rdf:type schema:DefinedTerm
109 Na705e1bdc22e4136bff129122835a2a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name B-Lymphocytes
111 rdf:type schema:DefinedTerm
112 Na8319bd2ceaa4814bd56ea862c4f6ab2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Thymus Gland
114 rdf:type schema:DefinedTerm
115 Nbfc176013eb64ce6a0a3f8f7f2811542 schema:name doi
116 schema:value 10.1038/ni956
117 rdf:type schema:PropertyValue
118 Nc4c705c857fe4d17bdcd0debad3bd807 schema:name nlm_unique_id
119 schema:value 100941354
120 rdf:type schema:PropertyValue
121 Nd9d604a0760e4404a0d37984566e64d5 schema:volumeNumber 4
122 rdf:type schema:PublicationVolume
123 Ndcf44aa3474640c8a4ec84c655d2dda2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cell Differentiation
125 rdf:type schema:DefinedTerm
126 Ne055c933f4ac43b5abb7edf9cecca251 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Mice
128 rdf:type schema:DefinedTerm
129 Ne4ac481849b74ae989f410faaddf55a0 schema:name readcube_id
130 schema:value 7e99eb53c9dbbce6540f7e940b7f017c93c850d5ff2bcab4a7ab0e650e24995b
131 rdf:type schema:PropertyValue
132 Nf5123a13341345faa501558571a090ba schema:name Springer Nature - SN SciGraph project
133 rdf:type schema:Organization
134 Nf93163c44ac045c4a86d02d201afb17b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Cystatin C
136 rdf:type schema:DefinedTerm
137 Nff794b6380a142869b354b135ad6569d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Interleukin-7
139 rdf:type schema:DefinedTerm
140 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biological Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
144 schema:name Biochemistry and Cell Biology
145 rdf:type schema:DefinedTerm
146 sg:journal.1022778 schema:issn 1529-2908
147 1529-2916
148 schema:name Nature Immunology
149 rdf:type schema:Periodical
150 sg:person.01077137664.28 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
151 schema:familyName Vieira
152 schema:givenName Paulo
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077137664.28
154 rdf:type schema:Person
155 sg:person.01176613253.25 schema:affiliation https://www.grid.ac/institutes/grid.6190.e
156 schema:familyName Voßhenrich
157 schema:givenName Christian A J
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176613253.25
159 rdf:type schema:Person
160 sg:person.01202454353.33 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
161 schema:familyName Di Santo
162 schema:givenName James P
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202454353.33
164 rdf:type schema:Person
165 sg:person.01261504775.94 schema:affiliation https://www.grid.ac/institutes/grid.418123.d
166 schema:familyName Müller
167 schema:givenName Werner
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261504775.94
169 rdf:type schema:Person
170 sg:person.0657136000.86 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
171 schema:familyName Cumano
172 schema:givenName Ana
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657136000.86
174 rdf:type schema:Person
175 sg:pub.10.1038/360225a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011545272
176 https://doi.org/10.1038/360225a0
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/3877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024424756
179 https://doi.org/10.1038/3877
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/76923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021044896
182 https://doi.org/10.1038/76923
183 rdf:type schema:CreativeWork
184 https://app.dimensions.ai/details/publication/pub.1074262632 schema:CreativeWork
185 https://app.dimensions.ai/details/publication/pub.1074553504 schema:CreativeWork
186 https://app.dimensions.ai/details/publication/pub.1078481993 schema:CreativeWork
187 https://app.dimensions.ai/details/publication/pub.1079044756 schema:CreativeWork
188 https://app.dimensions.ai/details/publication/pub.1082656383 schema:CreativeWork
189 https://app.dimensions.ai/details/publication/pub.1082960792 schema:CreativeWork
190 https://app.dimensions.ai/details/publication/pub.1083379021 schema:CreativeWork
191 https://doi.org/10.1002/1521-4141(200006)30:6<1614::aid-immu1614>3.0.co;2-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1015669673
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1002/eji.1830260103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029658979
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/0092-8674(90)90300-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002712862
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1016/0092-8674(92)90029-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1009230025
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/0092-8674(93)90325-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1001747744
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/1074-7613(95)90047-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004958298
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/1074-7613(95)90167-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038314822
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/s0167-5699(97)01203-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021963075
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/s0952-7915(03)00012-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015389230
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/s0960-9822(01)00087-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048172167
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/s1044532302000702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025137679
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/s1074-7613(02)00386-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019304014
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s1074-7613(02)00419-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019142759
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1034/j.1600-065x.2002.18904.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037856206
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1073/pnas.92.2.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039826657
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1073/pnas.92.3.773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034344973
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1073/pnas.96.17.9797 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025945499
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1084/jem.173.5.1213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024075750
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1084/jem.180.5.1955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038785599
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1084/jem.181.4.1519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052659065
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1084/jem.189.2.319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009160305
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1084/jem.192.5.659 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001838754
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1084/jem.192.5.671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004447169
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1084/jem.194.8.1141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047570829
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1084/jem.20020784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052965351
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/j.1600-065x.1994.tb00665.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000451565
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/j.1600-065x.1995.tb00095.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025306014
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1111/j.1600-065x.1998.tb01226.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031499494
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1126/science.8266077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653885
248 rdf:type schema:CreativeWork
249 https://doi.org/10.4049/jimmunol.168.7.3288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075018042
250 rdf:type schema:CreativeWork
251 https://www.grid.ac/institutes/grid.418123.d schema:alternateName GBF German Research Centre for Biotechnology
252 schema:name Department of Experimental Immunology, GBF, 38124 Braunschweig, Germany.
253 Institute for Genetics, University of Cologne, 50931 Cologne, Germany.
254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
256 schema:name Unité des Cytokines et Développement Lymphoïde, INSERM Equipe, 101 Institut Pasteur, 75724 Paris, France.
257 Unité du Développement des Lymphocytes, CNRS URA 1961, Institut Pasteur, 75724 Paris, France.
258 rdf:type schema:Organization
259 https://www.grid.ac/institutes/grid.6190.e schema:alternateName University of Cologne
260 schema:name Institute for Genetics, University of Cologne, 50931 Cologne, Germany.
261 Unité des Cytokines et Développement Lymphoïde, INSERM Equipe, 101 Institut Pasteur, 75724 Paris, France.
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...