Ontology type: schema:ScholarlyArticle
2003-05
AUTHORSReiko Shinkura, Ming Tian, Michele Smith, Katrin Chua, Yuko Fujiwara, Frederick W. Alt
ABSTRACTImmunoglobulin heavy chain (IgH) class switch recombination (CSR) takes place between large switch (S) regions that precede exons of the constant region. The precise functions of the S region are controversial, although transcription of the S region targets CSR. We have tested the effects of deletion, inversion and replacement of the endogenous 12-kilobase S(gamma1) region on CSR in vivo. Here we show that S(gamma1) is required for CSR, that CSR is effected by a 1-kilobase sequence that generates a G-rich transcript, and that inversion of S(gamma1) or the G-rich sequence decreases CSR. We conclude that S(gamma1) function is dependent on orientation and lacks an absolute requirement for common S region motifs. We propose that single-stranded DNA stabilized by transcription-dependent, higher order structures is a primary substrate of CSR. More... »
PAGES435
http://scigraph.springernature.com/pub.10.1038/ni918
DOIhttp://dx.doi.org/10.1038/ni918
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/12679811
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"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87078_00000000.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ni918"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni918'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni918'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni918'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni918'
This table displays all metadata directly associated to this object as RDF triples.
343 TRIPLES
21 PREDICATES
98 URIs
33 LITERALS
21 BLANK NODES