The influence of transcriptional orientation on endogenous switch region function View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-05

AUTHORS

Reiko Shinkura, Ming Tian, Michele Smith, Katrin Chua, Yuko Fujiwara, Frederick W. Alt

ABSTRACT

Immunoglobulin heavy chain (IgH) class switch recombination (CSR) takes place between large switch (S) regions that precede exons of the constant region. The precise functions of the S region are controversial, although transcription of the S region targets CSR. We have tested the effects of deletion, inversion and replacement of the endogenous 12-kilobase S(gamma1) region on CSR in vivo. Here we show that S(gamma1) is required for CSR, that CSR is effected by a 1-kilobase sequence that generates a G-rich transcript, and that inversion of S(gamma1) or the G-rich sequence decreases CSR. We conclude that S(gamma1) function is dependent on orientation and lacks an absolute requirement for common S region motifs. We propose that single-stranded DNA stabilized by transcription-dependent, higher order structures is a primary substrate of CSR. More... »

PAGES

435

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni918

DOI

http://dx.doi.org/10.1038/ni918

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028603147

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12679811


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