Dynamic programming of CD8+ T lymphocyte responses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04

AUTHORS

Marianne J.B. van Stipdonk, Gijs Hardenberg, Martijn S. Bijker, Edward E. Lemmens, Nathalie M. Droin, Douglas R. Green, Stephen P. Schoenberger

ABSTRACT

The initial encounter with an antigen-presenting cell (APC) is the primary force behind the expansion, differentiation and survival of naive T cells. Using an APC that permits temporal control of priming, we examined whether the duration of antigenic stimulation can influence the functional development of CD8+ cytotoxic T lymphocytes (CTLs) in vivo. Whereas CTLs given a 4-h stimulus underwent an abortive clonal expansion with transient surface CD25 expression, those given a 20-h stimulus sustained CD25 up-regulation, proliferated extensively, and efficiently mediated destruction of peripheral target tissues. Our results show that an instructional program preceding the first cell division integrates differences in signal strength into the decision to activate versus tolerize specific CTL clones. More... »

PAGES

361-365

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni912

DOI

http://dx.doi.org/10.1038/ni912

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015434230

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12640451


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