Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-11

AUTHORS

Patrick S Costello, Maighread Gallagher, Doreen A Cantrell

ABSTRACT

T cell activation is triggered by several hours of contact with peptide-major histocompatibility (MHC) complexes on the surface of antigen-presenting cells (APCs). The nature and location of the sustained signal transduction pathways required for T cell activation are unknown. We show here that the production of phosphatidylinositol(3,4,5)triphosphate (PIP3) was dynamically sustained for hours as T cells responded to antigen. In addition, sustained elevation of PIP3 was essential for T cell proliferation. There was PIP3 accumulation in the T cell-APC contact zone and at the antipodal pole of the cell. The immune synapse is thus not the sole site of sustained signal transduction in activated T cells. More... »

PAGES

1082-1089

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni848

DOI

http://dx.doi.org/10.1038/ni848

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040598008

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12389042


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