HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10-07

AUTHORS

Stephen A. Migueles, Alisha C. Laborico, W. Lesley Shupert, M. Shirin Sabbaghian, Ronald Rabin, Claire W. Hallahan, Debbie Van Baarle, Stefan Kostense, Frank Miedema, Mary McLaughlin, Linda Ehler, Julia Metcalf, Shuying Liu, Mark Connors

ABSTRACT

It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This proliferation was coupled to increases in perforin expression. These results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function. In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control. More... »

PAGES

1061-1068

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni845

DOI

http://dx.doi.org/10.1038/ni845

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030023651

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12368910


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43 schema:description It is unclear why immunological control of HIV replication is incomplete in most infected individuals. We examined here the CD8+ T cell response to HIV-infected CD4+ T cells in rare patients with immunological control of HIV. Although high frequencies of HIV-specific CD8+ T cells were present in nonprogressors and progressors, only those of nonprogressors maintained a high proliferative capacity. This proliferation was coupled to increases in perforin expression. These results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function. In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.
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