Staging and resetting T cell activation in SMACs View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-10

AUTHORS

Benjamin A Freiberg, Hannah Kupfer, William Maslanik, Joe Delli, John Kappler, Dennis M Zaller, Abraham Kupfer

ABSTRACT

During the productive interaction of T cells with antigen-presenting cells (APCs), engaged receptors, including the T cell antigen receptors and their associated tyrosine kinases, assemble into spatially segregated supramolecular activation clusters (SMACs) at the area of cell contact. Here, we studied intracellular signaling in SMACs by three-dimensional immunofluorescence microscopic localization of CD3, CD45, talin, phosphotyrosine, Lck and phosphorylated ZAP-70 in T cell-APC conjugates. Two distinct phases of spatial-temporal activation, one before and one after SMAC formation, which were separated by a brief state of inactivation caused by CD45, were observed at the T cell-APC contact area. We propose that pre-SMAC signals are sufficient to activate cell adhesion, but not productive T cell responses, which require orchestrated signaling in SMACs. More... »

PAGES

911-917

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni836

DOI

http://dx.doi.org/10.1038/ni836

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017721092

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12244310


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