Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Taro Fukao, Taketo Yamada, Masanobu Tanabe, Yasuo Terauchi, Takayuki Ota, Tetsuro Takayama, Tomoichiro Asano, Tsutomu Takeuchi, Takashi Kadowaki, Jun-ichi Hata, Shigeo Koyasu

ABSTRACT

Mice that lack the p85alpha regulatory subunit of phosphatidylinositol-3 kinase (PI3K) are deficient in gastrointestinal and peritoneal mast cells but have dermal mast cells. Accordingly, these mice show impaired bacterial clearance in response to acute septic peritonitis and are highly susceptible to infection by the intestinal nematode Strongyloides venezuelensis. Systemic anaphylactic shock responses, however, are intact. We found that although reconstitution of PI3Kminus sign/minus sign mice with bone marrow--derived mast cells (BMMCs) restored anti-bacterial immunity, only T helper type 2 (TH2)-conditioned BMMCs, not "standard" BMMCs, were able to restore anti-nematode immunity. This finding highlights the importance of the TH2 response in the control of nematode infection. Thus, PI3K likely plays an essential role in host immune responses by regulating both the development and induction of mast cells. More... »

PAGES

295-304

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni768

DOI

http://dx.doi.org/10.1038/ni768

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031448210

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11850627


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