Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-03

AUTHORS

Eric Sebzda, Madelon Bracke, Tamara Tugal, Nancy Hogg, Doreen Ann Cantrell

ABSTRACT

T cell receptor (TCR) stimulation activates the small GTPase Rap1A, which is reported to antagonize Ras signaling and induces T cell anergy. To address its role in vivo, we generated transgenic mice that constitutively expressed active Rap1A within the T cell lineage. We found that active Rap1A did not interfere with the Ras signaling pathway or antagonize T cell activation. Instead of anergy, the T lymphocytes that constitutively expressed active Rap1A showed enhanced TCR-mediated responses, both in thymocytes and mature T cells. In addition, Rap1A activation was sufficient to induce strong activation of the beta1 and beta2 integrins via an avidity-modulation mechanism. This shows that, far from playing an inhibitory role during T cell activation, Rap1A positively influences T cells by augmenting lymphocyte responses and directing integrin activation. More... »

PAGES

251-258

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni765

DOI

http://dx.doi.org/10.1038/ni765

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028631372

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11836528


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