Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance View Full Text


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Article Info

DATE

2002-02

AUTHORS

Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi, Yasumasa Ishida, Shimon Sakaguchi

ABSTRACT

CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gene superfamily--is predominantly expressed on CD25(+)CD4(+) T cells and on CD25(+)CD4(+)CD8(-) thymocytes in normal naïve mice. We found that stimulation of GITR abrogated CD25(+)CD4(+) T cell-mediated suppression. In addition, removal of GITR-expressing T cells or administration of a monoclonal antibody to GITR produced organ-specific autoimmune disease in otherwise normal mice. Thus, GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells and could be a suitable molecular target for preventing or treating autoimmune disease. More... »

PAGES

135-142

Journal

TITLE

Nature Immunology

ISSUE

2

VOLUME

3

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni759

    DOI

    http://dx.doi.org/10.1038/ni759

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021808391

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/11812990


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    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni759'

    Turtle is a human-readable linked data format.

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    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni759'


     

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