Defective T cell activation and autoimmune disorder in Stra13-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

Hong Sun, Binfeng Lu, Rong-Qin Li, Richard A. Flavell, Reshma Taneja

ABSTRACT

Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation. In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia. Consequently, aging Stra13-/- mice develop autoimmune disease characterized by accumulation of spontaneously activated T and B cells, circulating autoantibodies, infiltration of T and B lymphocytes in several organs and immune complex deposition in glomeruli. Our studies identify Stra13 as a key regulator of lymphocyte activation that is vital for maintenance of self-tolerance and for constraint of autoimmunity. More... »

PAGES

1040

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni721

DOI

http://dx.doi.org/10.1038/ni721

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015615236

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11668339


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