Defective T cell activation and autoimmune disorder in Stra13-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

Hong Sun, Binfeng Lu, Rong-Qin Li, Richard A. Flavell, Reshma Taneja

ABSTRACT

Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation. In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia. Consequently, aging Stra13-/- mice develop autoimmune disease characterized by accumulation of spontaneously activated T and B cells, circulating autoantibodies, infiltration of T and B lymphocytes in several organs and immune complex deposition in glomeruli. Our studies identify Stra13 as a key regulator of lymphocyte activation that is vital for maintenance of self-tolerance and for constraint of autoimmunity. More... »

PAGES

1040

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni721

DOI

http://dx.doi.org/10.1038/ni721

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015615236

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11668339


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoimmune Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basic Helix-Loop-Helix Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chimera", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fas Ligand Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Targeting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homeodomain Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperplasia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immune Complex Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymph Nodes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphoid Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membrane Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spleen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "fas Receptor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Hong", 
        "id": "sg:person.01300102751.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300102751.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Binfeng", 
        "id": "sg:person.0733055410.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733055410.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Rong-Qin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yale University", 
          "id": "https://www.grid.ac/institutes/grid.47100.32", 
          "name": [
            "Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Flavell", 
        "givenName": "Richard A.", 
        "id": "sg:person.013636762157.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013636762157.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taneja", 
        "givenName": "Reshma", 
        "id": "sg:person.01206336126.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206336126.49"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000015470", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001719152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7539157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001882800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90180-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003314530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830251111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004076046"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.24.3136", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008201216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.070526297", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010465521"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90028-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012827151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5312.589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014082032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(01)00085-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015794110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.17.1.149", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016546466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.6.2245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017260851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(93)80067-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020816997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/cimm.1997.1200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025825696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029489540", 
          "https://doi.org/10.1038/sj.onc.1204637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029489540", 
          "https://doi.org/10.1038/sj.onc.1204637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/383787a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030311743", 
          "https://doi.org/10.1038/383787a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80103-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030923499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032437385", 
          "https://doi.org/10.1186/ar85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.14.1.233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036190830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81349-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036294823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81042-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037220363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(00)80054-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038008617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(95)90013-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038358151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90375-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038464532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80566-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038665630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.11.16.2052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039426845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.13.9.1203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040582199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/356314a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041635124", 
          "https://doi.org/10.1038/356314a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0952-7915(98)80175-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041863964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80170-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044876099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/284364a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045652593", 
          "https://doi.org/10.1038/284364a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4889(00)00082-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047369251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0697-161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047492526", 
          "https://doi.org/10.1038/ng0697-161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.immunol.19.1.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049125532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2567.2000.00133.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049702101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.181.1.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053575031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3131876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062593378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7770771", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649206"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074669253", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-11", 
    "datePublishedReg": "2001-11-01", 
    "description": "Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation. In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia. Consequently, aging Stra13-/- mice develop autoimmune disease characterized by accumulation of spontaneously activated T and B cells, circulating autoantibodies, infiltration of T and B lymphocytes in several organs and immune complex deposition in glomeruli. Our studies identify Stra13 as a key regulator of lymphocyte activation that is vital for maintenance of self-tolerance and for constraint of autoimmunity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ni721", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1022778", 
        "issn": [
          "1529-2908", 
          "1529-2916"
        ], 
        "name": "Nature Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "11", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "name": "Defective T cell activation and autoimmune disorder in Stra13-deficient mice", 
    "pagination": "1040", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4a662768cc0e3d67ecbbe26b564a6956f0736bfef2da80acbce7fbd3130816ef"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11668339"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100941354"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ni721"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015615236"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ni721", 
      "https://app.dimensions.ai/details/publication/pub.1015615236"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87082_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ni721"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni721'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni721'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni721'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni721'


 

This table displays all metadata directly associated to this object as RDF triples.

338 TRIPLES      21 PREDICATES      97 URIs      51 LITERALS      39 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ni721 schema:about N02a28a7cd9424d0bab1f700d3806b577
2 N1e99adcea8b94a73860be723672ae6ad
3 N22765e68bcc34ef99adfa23ee2ceb37f
4 N2d42de01bd634222825a2f7435f12dcc
5 N372a58b8d5094b5da8b74312bd28e7e2
6 N3ff7f32ffce541058ab703d9027c7ba7
7 N48795ef19dd24f4f89cb07849dce8d9d
8 N4ce575b632a24800ba39a2e3013586d6
9 N51942b19228444cf96e8f879bba9211b
10 N52f5ed7bd6304c13a6a35f4eb171ed8e
11 N5ef9710158194a51a676a9b390e819f9
12 N6069f1388355447c87814fa7a3c23237
13 N634b4cb15d274c858f3a11bc11978817
14 N72a8f9403af34011af3fe94c70a670ca
15 N8d9ab199f98242679910f11860ce7ad8
16 N992b9a830eb0403c81f60ca94d67541a
17 Na6b3dad7fc1141abb34bd50463daab45
18 Na76c22307e9941128839be05299b0c13
19 Na7beed35466442f58d29126b8273b1a7
20 Nb2d44bc429c54799b9d8d2cba6b20c52
21 Nba12d7de217c47cab1155fc8bfe750a6
22 Nbda2047d81174c2db3f49c3733bfea36
23 Nc16feac1d6df490aabfd418a73a56500
24 Nc71e6bfbabdc47b9913348c64a88ce0b
25 Ndb5272530e71463484149c4e6e42cef9
26 Ne0c8e48cea9b40b486e8faa2a14b0a38
27 Ne0fe1c869b5a45b7b04fb73b20fd848f
28 Nead41f291668461e804d96b2be00a1d4
29 Nf3f0c45989c54e469cca079560300214
30 Nfacc0fd3bcd14261bd3d5777c88d9cfc
31 anzsrc-for:11
32 anzsrc-for:1107
33 schema:author N712f5b56cdba4aa8bd72e90ee4e83b36
34 schema:citation sg:pub.10.1038/284364a0
35 sg:pub.10.1038/356314a0
36 sg:pub.10.1038/383787a0
37 sg:pub.10.1038/ng0697-161
38 sg:pub.10.1038/sj.onc.1204637
39 sg:pub.10.1186/ar85
40 https://app.dimensions.ai/details/publication/pub.1074669253
41 https://doi.org/10.1002/eji.1830251111
42 https://doi.org/10.1006/cimm.1997.1200
43 https://doi.org/10.1016/0092-8674(93)80067-o
44 https://doi.org/10.1016/0092-8674(94)90375-1
45 https://doi.org/10.1016/0092-8674(95)90013-6
46 https://doi.org/10.1016/1074-7613(95)90028-4
47 https://doi.org/10.1016/1074-7613(95)90180-9
48 https://doi.org/10.1016/s0092-8674(00)81042-9
49 https://doi.org/10.1016/s0092-8674(00)81349-5
50 https://doi.org/10.1016/s0167-4889(00)00082-3
51 https://doi.org/10.1016/s0952-7915(98)80175-1
52 https://doi.org/10.1016/s1074-7613(00)80103-x
53 https://doi.org/10.1016/s1074-7613(00)80170-3
54 https://doi.org/10.1016/s1074-7613(00)80566-x
55 https://doi.org/10.1016/s1074-7613(01)00085-1
56 https://doi.org/10.1016/s1097-2765(00)80054-4
57 https://doi.org/10.1046/j.1365-2567.2000.00133.x
58 https://doi.org/10.1073/pnas.070526297
59 https://doi.org/10.1073/pnas.93.6.2245
60 https://doi.org/10.1084/jem.181.1.71
61 https://doi.org/10.1101/gad.11.16.2052
62 https://doi.org/10.1101/gad.13.9.1203
63 https://doi.org/10.1101/gad.9.24.3136
64 https://doi.org/10.1126/science.276.5312.589
65 https://doi.org/10.1126/science.3131876
66 https://doi.org/10.1126/science.7539157
67 https://doi.org/10.1126/science.7770771
68 https://doi.org/10.1146/annurev.immunol.14.1.233
69 https://doi.org/10.1146/annurev.immunol.17.1.149
70 https://doi.org/10.1146/annurev.immunol.19.1.23
71 https://doi.org/10.1159/000015470
72 schema:datePublished 2001-11
73 schema:datePublishedReg 2001-11-01
74 schema:description Stra13, a basic helix-loop-helix transcription factor, is up-regulated upon activation of CD4+ T cells. Here we show that Stra13-deficient mice exhibit defects in several phases of CD4+ T cell activation. In vivo, Stra13 deficiency results in ineffective elimination of activated T and B cells, which accumulate progressively, leading to lymphoid organ hyperplasia. Consequently, aging Stra13-/- mice develop autoimmune disease characterized by accumulation of spontaneously activated T and B cells, circulating autoantibodies, infiltration of T and B lymphocytes in several organs and immune complex deposition in glomeruli. Our studies identify Stra13 as a key regulator of lymphocyte activation that is vital for maintenance of self-tolerance and for constraint of autoimmunity.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree false
78 schema:isPartOf N33a60a6a0ad540099ec5713f7e9763b8
79 N781e96c4b80d45ffa1161cd7fb11b870
80 sg:journal.1022778
81 schema:name Defective T cell activation and autoimmune disorder in Stra13-deficient mice
82 schema:pagination 1040
83 schema:productId N28982d366119415db50b4dd17d71b239
84 N41535001585a47aab44646c1b364a4d0
85 Nd2dbee678fdb4e178f66910a74219ac4
86 Nd3f773c8fa424c34acd988242c612419
87 Nfcbb7efd2f6443f4b3e67f55e3f0febd
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015615236
89 https://doi.org/10.1038/ni721
90 schema:sdDatePublished 2019-04-11T12:21
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N22cc4f39b48b4973b7d7c7a3fc180485
93 schema:url https://www.nature.com/articles/ni721
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N02a28a7cd9424d0bab1f700d3806b577 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Spleen
99 rdf:type schema:DefinedTerm
100 N0c7415fbdd734daba47e8c257919edaa rdf:first sg:person.0733055410.08
101 rdf:rest Nce3c6c82656441588998432d484a921f
102 N1e99adcea8b94a73860be723672ae6ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Membrane Glycoproteins
104 rdf:type schema:DefinedTerm
105 N22765e68bcc34ef99adfa23ee2ceb37f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Gene Targeting
107 rdf:type schema:DefinedTerm
108 N22cc4f39b48b4973b7d7c7a3fc180485 schema:name Springer Nature - SN SciGraph project
109 rdf:type schema:Organization
110 N28982d366119415db50b4dd17d71b239 schema:name readcube_id
111 schema:value 4a662768cc0e3d67ecbbe26b564a6956f0736bfef2da80acbce7fbd3130816ef
112 rdf:type schema:PropertyValue
113 N2d42de01bd634222825a2f7435f12dcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Mice
115 rdf:type schema:DefinedTerm
116 N33a60a6a0ad540099ec5713f7e9763b8 schema:volumeNumber 2
117 rdf:type schema:PublicationVolume
118 N372a58b8d5094b5da8b74312bd28e7e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Hyperplasia
120 rdf:type schema:DefinedTerm
121 N3ff7f32ffce541058ab703d9027c7ba7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Lymphocyte Activation
123 rdf:type schema:DefinedTerm
124 N41535001585a47aab44646c1b364a4d0 schema:name doi
125 schema:value 10.1038/ni721
126 rdf:type schema:PropertyValue
127 N48795ef19dd24f4f89cb07849dce8d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Autoimmune Diseases
129 rdf:type schema:DefinedTerm
130 N4ce575b632a24800ba39a2e3013586d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Animals
132 rdf:type schema:DefinedTerm
133 N51942b19228444cf96e8f879bba9211b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Chimera
135 rdf:type schema:DefinedTerm
136 N52f5ed7bd6304c13a6a35f4eb171ed8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Aging
138 rdf:type schema:DefinedTerm
139 N54664d42406e4a5995b870225a107708 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
140 schema:familyName Li
141 schema:givenName Rong-Qin
142 rdf:type schema:Person
143 N5ef9710158194a51a676a9b390e819f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name B-Lymphocytes
145 rdf:type schema:DefinedTerm
146 N6069f1388355447c87814fa7a3c23237 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Gene Expression Regulation
148 rdf:type schema:DefinedTerm
149 N634b4cb15d274c858f3a11bc11978817 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Mice, Knockout
151 rdf:type schema:DefinedTerm
152 N712f5b56cdba4aa8bd72e90ee4e83b36 rdf:first sg:person.01300102751.77
153 rdf:rest N0c7415fbdd734daba47e8c257919edaa
154 N72a8f9403af34011af3fe94c70a670ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Female
156 rdf:type schema:DefinedTerm
157 N781e96c4b80d45ffa1161cd7fb11b870 schema:issueNumber 11
158 rdf:type schema:PublicationIssue
159 N84333d24b8ca4238bf92454655f36115 rdf:first sg:person.01206336126.49
160 rdf:rest rdf:nil
161 N8d9ab199f98242679910f11860ce7ad8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Fas Ligand Protein
163 rdf:type schema:DefinedTerm
164 N992b9a830eb0403c81f60ca94d67541a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name fas Receptor
166 rdf:type schema:DefinedTerm
167 Na6b3dad7fc1141abb34bd50463daab45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Male
169 rdf:type schema:DefinedTerm
170 Na76c22307e9941128839be05299b0c13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cell Differentiation
172 rdf:type schema:DefinedTerm
173 Na7beed35466442f58d29126b8273b1a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Immune Complex Diseases
175 rdf:type schema:DefinedTerm
176 Nab5190eb9244474d8e8ac28aaf14a3f4 rdf:first sg:person.013636762157.29
177 rdf:rest N84333d24b8ca4238bf92454655f36115
178 Nb2d44bc429c54799b9d8d2cba6b20c52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Cytokines
180 rdf:type schema:DefinedTerm
181 Nba12d7de217c47cab1155fc8bfe750a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Genotype
183 rdf:type schema:DefinedTerm
184 Nbda2047d81174c2db3f49c3733bfea36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name CD4-Positive T-Lymphocytes
186 rdf:type schema:DefinedTerm
187 Nc16feac1d6df490aabfd418a73a56500 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Mice, Inbred C57BL
189 rdf:type schema:DefinedTerm
190 Nc71e6bfbabdc47b9913348c64a88ce0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Basic Helix-Loop-Helix Transcription Factors
192 rdf:type schema:DefinedTerm
193 Nce3c6c82656441588998432d484a921f rdf:first N54664d42406e4a5995b870225a107708
194 rdf:rest Nab5190eb9244474d8e8ac28aaf14a3f4
195 Nd2dbee678fdb4e178f66910a74219ac4 schema:name nlm_unique_id
196 schema:value 100941354
197 rdf:type schema:PropertyValue
198 Nd3f773c8fa424c34acd988242c612419 schema:name pubmed_id
199 schema:value 11668339
200 rdf:type schema:PropertyValue
201 Ndb5272530e71463484149c4e6e42cef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Homeodomain Proteins
203 rdf:type schema:DefinedTerm
204 Ne0c8e48cea9b40b486e8faa2a14b0a38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Lymphoid Tissue
206 rdf:type schema:DefinedTerm
207 Ne0fe1c869b5a45b7b04fb73b20fd848f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Glomerulonephritis
209 rdf:type schema:DefinedTerm
210 Nead41f291668461e804d96b2be00a1d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Autoantibodies
212 rdf:type schema:DefinedTerm
213 Nf3f0c45989c54e469cca079560300214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Lymph Nodes
215 rdf:type schema:DefinedTerm
216 Nfacc0fd3bcd14261bd3d5777c88d9cfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Apoptosis
218 rdf:type schema:DefinedTerm
219 Nfcbb7efd2f6443f4b3e67f55e3f0febd schema:name dimensions_id
220 schema:value pub.1015615236
221 rdf:type schema:PropertyValue
222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
223 schema:name Medical and Health Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
226 schema:name Immunology
227 rdf:type schema:DefinedTerm
228 sg:journal.1022778 schema:issn 1529-2908
229 1529-2916
230 schema:name Nature Immunology
231 rdf:type schema:Periodical
232 sg:person.01206336126.49 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
233 schema:familyName Taneja
234 schema:givenName Reshma
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206336126.49
236 rdf:type schema:Person
237 sg:person.01300102751.77 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
238 schema:familyName Sun
239 schema:givenName Hong
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300102751.77
241 rdf:type schema:Person
242 sg:person.013636762157.29 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
243 schema:familyName Flavell
244 schema:givenName Richard A.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013636762157.29
246 rdf:type schema:Person
247 sg:person.0733055410.08 schema:affiliation https://www.grid.ac/institutes/grid.47100.32
248 schema:familyName Lu
249 schema:givenName Binfeng
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733055410.08
251 rdf:type schema:Person
252 sg:pub.10.1038/284364a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045652593
253 https://doi.org/10.1038/284364a0
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/356314a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041635124
256 https://doi.org/10.1038/356314a0
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/383787a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030311743
259 https://doi.org/10.1038/383787a0
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ng0697-161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047492526
262 https://doi.org/10.1038/ng0697-161
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/sj.onc.1204637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029489540
265 https://doi.org/10.1038/sj.onc.1204637
266 rdf:type schema:CreativeWork
267 sg:pub.10.1186/ar85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032437385
268 https://doi.org/10.1186/ar85
269 rdf:type schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1074669253 schema:CreativeWork
271 https://doi.org/10.1002/eji.1830251111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004076046
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1006/cimm.1997.1200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025825696
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/0092-8674(93)80067-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1020816997
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/0092-8674(94)90375-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038464532
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0092-8674(95)90013-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038358151
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/1074-7613(95)90028-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012827151
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/1074-7613(95)90180-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003314530
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s0092-8674(00)81042-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037220363
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0092-8674(00)81349-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036294823
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s0167-4889(00)00082-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047369251
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1016/s0952-7915(98)80175-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041863964
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/s1074-7613(00)80103-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1030923499
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/s1074-7613(00)80170-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044876099
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/s1074-7613(00)80566-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038665630
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/s1074-7613(01)00085-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015794110
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/s1097-2765(00)80054-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038008617
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1046/j.1365-2567.2000.00133.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049702101
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1073/pnas.070526297 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010465521
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1073/pnas.93.6.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017260851
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1084/jem.181.1.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053575031
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1101/gad.11.16.2052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039426845
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1101/gad.13.9.1203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040582199
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1101/gad.9.24.3136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008201216
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1126/science.276.5312.589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014082032
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1126/science.3131876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062593378
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1126/science.7539157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001882800
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1126/science.7770771 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649206
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1146/annurev.immunol.14.1.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036190830
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1146/annurev.immunol.17.1.149 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016546466
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1146/annurev.immunol.19.1.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049125532
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1159/000015470 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001719152
332 rdf:type schema:CreativeWork
333 https://www.grid.ac/institutes/grid.47100.32 schema:alternateName Yale University
334 schema:name Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.59734.3c schema:alternateName Icahn School of Medicine at Mount Sinai
337 schema:name Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.
338 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...