Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02

AUTHORS

Jessica Strid, Scott J Roberts, Renata B Filler, Julia M Lewis, Bernice Y Kwong, William Schpero, Daniel H Kaplan, Adrian C Hayday, Michael Girardi

ABSTRACT

The self-encoded ligands MICA (human) and Rae-1 (mouse) for the cytotoxic lymphocyte activating receptor NKG2D are highly expressed in carcinomas and inflammatory lesions and have been linked to immunosurveillance and graft rejection. However, whether NKG2D ligands have an intrinsic ability to acutely regulate tissue-associated immune compartments is not known. Here we show that epidermis-specific upregulation of Rae-1 induced rapid, coincident and reversible changes in the organization of tissue-resident V(gamma)5V(delta)1 TCRgammadelta+ intraepithelial T cells and Langerhans cells, swiftly followed by epithelial infiltration by unconventional alphabeta T cells. Whereas local V(gamma)5V(delta)1+ T cells limited carcinogenesis, Langerhans cells unexpectedly promoted it. These results provide unique insight into the early phases of tissue immunosurveillance and indicate that acute changes in NKG2D ligands may alone initiate a rapid, multifaceted immunosurveillance response in vivo. More... »

PAGES

146-154

References to SciGraph publications

  • 2005-08. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor in NATURE
  • 2006-04. Behavioral Responses of Epidermal Langerhans Cells In Situ to Local Pathological Stimuli in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-09. Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance in NATURE
  • 2002-11. Natural killer and natural killer-T cells in psoriasis in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1997-07. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity in NATURE
  • 2000-08. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages in NATURE IMMUNOLOGY
  • 1998-03. Dendritic cells and the control of immunity in NATURE
  • 1993-10. Mouse Skin Is Particularly Susceptible to Tumor Initiation During Early Anagen of the Hair Cycle: Possible Involvement of Hair Follicle Stem Cells in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2006-08. Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant in NATURE IMMUNOLOGY
  • 2004-03. NKT cells: what's in a name? in NATURE REVIEWS IMMUNOLOGY
  • 2004-01. A cancer immunosurveillance controversy in NATURE IMMUNOLOGY
  • 2005-09. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance in NATURE IMMUNOLOGY
  • 2004-01. Response to 'A cancer immunosurveillance controversy' in NATURE IMMUNOLOGY
  • 2000-12. Immune suppression and skin cancer development: regulation by NKT cells in NATURE IMMUNOLOGY
  • 2002-10. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation in NATURE
  • 2005-02. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function in NATURE IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1556

    DOI

    http://dx.doi.org/10.1038/ni1556

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033450095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18176566


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