Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02

AUTHORS

Jessica Strid, Scott J Roberts, Renata B Filler, Julia M Lewis, Bernice Y Kwong, William Schpero, Daniel H Kaplan, Adrian C Hayday, Michael Girardi

ABSTRACT

The self-encoded ligands MICA (human) and Rae-1 (mouse) for the cytotoxic lymphocyte activating receptor NKG2D are highly expressed in carcinomas and inflammatory lesions and have been linked to immunosurveillance and graft rejection. However, whether NKG2D ligands have an intrinsic ability to acutely regulate tissue-associated immune compartments is not known. Here we show that epidermis-specific upregulation of Rae-1 induced rapid, coincident and reversible changes in the organization of tissue-resident V(gamma)5V(delta)1 TCRgammadelta+ intraepithelial T cells and Langerhans cells, swiftly followed by epithelial infiltration by unconventional alphabeta T cells. Whereas local V(gamma)5V(delta)1+ T cells limited carcinogenesis, Langerhans cells unexpectedly promoted it. These results provide unique insight into the early phases of tissue immunosurveillance and indicate that acute changes in NKG2D ligands may alone initiate a rapid, multifaceted immunosurveillance response in vivo. More... »

PAGES

146-154

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1556

    DOI

    http://dx.doi.org/10.1038/ni1556

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1033450095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18176566


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