Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12

AUTHORS

Jason S Stumhofer, Jonathan S Silver, Arian Laurence, Paige M Porrett, Tajie H Harris, Laurence A Turka, Matthias Ernst, Christiaan J M Saris, John J O'Shea, Christopher A Hunter

ABSTRACT

Interleukin 10 (IL-10) has a prominent function in regulating the balance between protective and pathological T cell responses. Consistent with that activity, many sources of this cytokine are found in vivo, including from myeloid cells and a variety of T cell subsets. However, although there are many pathways that regulate innate production of IL-10, the factors that govern its synthesis by the adaptive response are poorly understood. Here we report that IL-27 and IL-6 induced T helper type 1 and type 2 cells, as well as T helper cells that produce IL-17, to secrete IL-10. This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory responses. More... »

PAGES

1363-1371

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1537

DOI

http://dx.doi.org/10.1038/ni1537

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019516627

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17994025


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