Germline-encoded recognition of diverse glycolipids by natural killer T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-10

AUTHORS

James P Scott-Browne, Jennifer L Matsuda, Thierry Mallevaey, Janice White, Natalie A Borg, James McCluskey, Jamie Rossjohn, John Kappler, Philippa Marrack, Laurent Gapin

ABSTRACT

Natural killer T cells expressing 'invariant' T cell receptor alpha-chains (TCRalpha chains) containing variable (V) and joining (J) region V(alpha)14-J(alpha)18 (V(alpha)14i) rearrangements recognize both endogenous and microbial glycolipids in the context of CD1d. How cells expressing an invariant TCRalpha chain and a restricted set of TCRbeta chains recognize structurally diverse antigens is not clear. Here we show that a V(alpha)14i TCR recognized many alpha-linked glycolipids by means of a 'hot-spot' of germline-encoded amino acids in complementarity-determining regions 3alpha, 1alpha and 2beta. This hot-spot did not shift during the recognition of structurally distinct antigens, suggesting that the V(alpha)14i TCR functions as a pattern-recognition receptor, conferring on natural killer T cells the ability to sense and respond in an innate way to pathogens displaying antigenic alpha-linked glycolipids. More... »

PAGES

1105-1113

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1510

    DOI

    http://dx.doi.org/10.1038/ni1510

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010605813

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17828267


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