Development, cytokine profile and function of human interleukin 17–producing helper T cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-09

AUTHORS

Nicholas J Wilson, Katia Boniface, Jason R Chan, Brent S McKenzie, Wendy M Blumenschein, Jeanine D Mattson, Beth Basham, Kathleen Smith, Taiying Chen, Franck Morel, Jean-Claude Lecron, Robert A Kastelein, Daniel J Cua, Terrill K McClanahan, Edward P Bowman, Rene de Waal Malefyt

ABSTRACT

T(H)-17 cells are a distinct lineage of proinflammatory T helper cells that are essential for autoimmune disease. In mice, commitment to the T(H)-17 lineage is dependent on transforming growth factor-beta and interleukin 6 (IL-6). Here we demonstrate that IL-23 and IL-1beta induced the development of human T(H)-17 cells expressing IL-17A, IL-17F, IL-22, IL-26, interferon-gamma, the chemokine CCL20 and transcription factor RORgammat. In situ, T(H)-17 cells were identified by expression of the IL-23 receptor and the memory T cell marker CD45RO. Psoriatic skin lesions contained IL-23-producing dendritic cells and were enriched in the cytokines produced by human T(H)-17 cells that promote the production of antimicrobial peptides in human keratinocytes. Our data collectively indicate that human and mouse T(H)-17 cells require distinct factors during differentiation and that human T(H)-17 cells may regulate innate immunity in epithelial cells. More... »

PAGES

950-957

References to SciGraph publications

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  • Journal

    TITLE

    Nature Immunology

    ISSUE

    9

    VOLUME

    8

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1497

    DOI

    http://dx.doi.org/10.1038/ni1497

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1043435108

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17676044


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