Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-07

AUTHORS

Jamie R Schoenborn, Michael O Dorschner, Masayuki Sekimata, Deanna M Santer, Maria Shnyreva, David R Fitzpatrick, John A Stamatoyannopoulos, Christopher B Wilson

ABSTRACT

Unlike the well defined T helper type 2 cytokine locus, little is known about the regulatory elements that govern the expression of Ifng, which encodes the 'signature' T helper type 1 cytokine interferon-gamma. Here our evolutionary analysis showed that the mouse Ifng locus diverged from the ancestral locus as a result of structural rearrangements producing deletion of the neighboring gene encoding interleukin 26 and disrupting synteny 57 kilobases upstream of Ifng. Proximal to that disruption, we identified by high-resolution mapping many regions with CD4+ T cell subset-specific epigenetic modifications. A subset of those regions represented enhancers, whereas others blocked the activity of upstream enhancers or insulated Ifng from neighboring chromatin. Our findings suggest that proper expression of Ifng is maintained through the collective action of multiple distal regulatory elements present in a region of about 100 kilobases flanking Ifng. More... »

PAGES

732-742

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1474

    DOI

    http://dx.doi.org/10.1038/ni1474

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046847727

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17546033


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