Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-06

AUTHORS

Eva V Acosta-Rodriguez, Laura Rivino, Jens Geginat, David Jarrossay, Marco Gattorno, Antonio Lanzavecchia, Federica Sallusto, Giorgio Napolitani

ABSTRACT

Interleukin 17 (IL-17)-producing T helper cells (T(H)-17 cells) have been characterized in mice as a distinct subset of effector cells, but their identity and properties in humans remain elusive. We report here that expression of CCR6 and CCR4 together identified human memory CD4+ T cells selectively producing IL-17 and expressing mRNA encoding the human ortholog of mouse RORgammat, a transcription factor, whereas CCR6 and CXCR3 identified T(H)1 cells producing interferon-gamma and T helper cells producing both interferon-gamma and IL-17. Memory T cells specific for Candida albicans were present mainly in the CCR6+CCR4+ T(H)-17 subset, whereas memory T cells specific for Mycobacterium tuberculosis were present in CCR6+CXCR3+ T helper type 1 subset. The elicitation of IL-17 responses correlated with the capacity of C. albicans hyphae to stimulate antigen-presenting cells for the priming of T(H)-17 responses in vitro and for the production of IL-23 but not IL-12. Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens. More... »

PAGES

639-646

References to SciGraph publications

  • 2003-02. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain in NATURE
  • 2005-11. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 in NATURE IMMUNOLOGY
  • 2006-05. Transforming growth factor-β induces development of the TH17 lineage in NATURE
  • 2007-04. IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge in NATURE IMMUNOLOGY
  • 2002-12. The lineage decisions of helper T cells in NATURE REVIEWS IMMUNOLOGY
  • 2003-04. Role of Macrophage Inflammatory Protein-3α and Its Ligand CCR6 in Rheumatoid Arthritis in LABORATORY INVESTIGATION
  • 2005-11. Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages in NATURE IMMUNOLOGY
  • 1999-08. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells in NATURE
  • 2004-01. Immunity to fungal infections in NATURE REVIEWS IMMUNOLOGY
  • 2003-01. Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytes in NATURE IMMUNOLOGY
  • 2001-08. CC Chemokine Receptor 4 Expression on Peripheral Blood CD4+ T Cells Reflects Disease Activity of Atopic Dermatitis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2006-11. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease in NATURE IMMUNOLOGY
  • 2005-08. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells in NATURE IMMUNOLOGY
  • Journal

    TITLE

    Nature Immunology

    ISSUE

    6

    VOLUME

    8

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1467

    DOI

    http://dx.doi.org/10.1038/ni1467

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038187346

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17486092


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