The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-03

AUTHORS

Arlene H Sharpe, E John Wherry, Rafi Ahmed, Gordon J Freeman

ABSTRACT

The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-L2. Studies have shown that PD-1-PD-L interactions control the induction and maintenance of peripheral T cell tolerance and indicate a previously unknown function for PD-L1 on nonhematopoietic cells in protecting tissues from autoimmune attack. PD-1 and its ligands have also been exploited by a variety of microorganisms to attenuate antimicrobial immunity and facilitate chronic infection. Here we examine the functions of PD-1 and its ligands in regulating antimicrobial and self-reactive T cell responses and discuss the therapeutic potential of manipulating this pathway. More... »

PAGES

239-245

References to SciGraph publications

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  • 2005-09. T cells and viral persistence: lessons from diverse infections in NATURE IMMUNOLOGY
  • 2002-04. Effector and memory T-cell differentiation: implications for vaccine development in NATURE REVIEWS IMMUNOLOGY
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  • 2006-09. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression in NATURE
  • 2002-12. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans in NATURE GENETICS
  • 1999-12. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion in NATURE MEDICINE
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  • 2005-08. PDCD1: a tissue-specific susceptibility locus for inherited inflammatory disorders in GENES & IMMUNITY
  • 2005-03. Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 in NATURE IMMUNOLOGY
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  • Journal

    TITLE

    Nature Immunology

    ISSUE

    3

    VOLUME

    8

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1443

    DOI

    http://dx.doi.org/10.1038/ni1443

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022269907

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17304234


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