ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-12

AUTHORS

Gisela Weskamp, Jill W Ford, Jamie Sturgill, Steve Martin, Andrew J P Docherty, Steven Swendeman, Neil Broadway, Dieter Hartmann, Paul Saftig, Shelby Umland, Atsuko Sehara-Fujisawa, Roy A Black, Andreas Ludwig, J David Becherer, Daniel H Conrad, Carl P Blobel

ABSTRACT

CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells is considered a key event in the allergic response. Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo. Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies. More... »

PAGES

1293-1298

References to SciGraph publications

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  • 2005-02. Anti-CD23 in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1399

    DOI

    http://dx.doi.org/10.1038/ni1399

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1005898302

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17072319


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