Transcription factor Pax5 (BSAP) transactivates the RAG-mediated VH-to-DJH rearrangement of immunoglobulin genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06

AUTHORS

Zhixin Zhang, Celia R Espinoza, Zhihong Yu, Robert Stephan, Ti He, G Stuart Williams, Peter D Burrows, James Hagman, Ann J Feeney, Max D Cooper

ABSTRACT

Immunoglobulin rearrangement from variable heavy chain (V(H)) to diversity (D)-joining heavy chain (J(H)), which occurs exclusively in B lineage cells, is impaired in mice deficient for the B lineage-specific transcription factor Pax5. Conversely, ectopic Pax5 expression in thymocytes promotes the rearrangement of D(H)-proximal V(H)7183 genes. In exploring the mechanism for Pax5 regulation of V(H)-to-DJ(H) recombination, we have identified multiple Pax5 binding sites in the coding regions of human and mouse V(H) gene segments. Pax5 bound to those sites in vitro and occupied V(H) genes in early human and mouse B lineage cells. Moreover, Pax5 interacted with the recombination-activating gene 1 (RAG1)-RAG2 complex to enhance RAG-mediated V(H) recombination signal sequence cleavage and recombination of a V(H) gene substrate. These findings indicate a direct activating function for Pax5 in RAG-mediated immunoglobulin V(H)-to-DJ(H) recombination. More... »

PAGES

616-624

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1339

DOI

http://dx.doi.org/10.1038/ni1339

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009159323

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16680144


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