An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-04

AUTHORS

Chyi-Song Hsieh, Ye Zheng, Yuqiong Liang, Jason D Fontenot, Alexander Y Rudensky

ABSTRACT

The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found that the TCR repertoire of thymic T(reg) cells in TCRbeta-transgenic mice was diverse and was more similar to that of peripheral T(reg) cells than that of nonregulatory T cells, suggesting that thymic T(reg) cells make a substantial contribution to the peripheral T(reg) cell population. Activated T cells in Foxp3-deficient mice, which lack T(reg) cells, 'preferentially' used TCRs found in the TCR repertoire of T(reg) cells in Foxp3-sufficient TCRbeta-transgenic mice, suggesting that these self-reactive TCRs contribute to the pathology of Foxp3-deficient mice. Our analyses suggest that T(reg) cells and potentially pathogenic autoimmune T cells use overlapping pools of self-reactive TCRs. More... »

PAGES

401-410

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1318

DOI

http://dx.doi.org/10.1038/ni1318

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049159396

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16532000


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Turtle is a human-readable linked data format.

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curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni1318'


 

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