Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-02

AUTHORS

Stephan Mathas, Martin Janz, Franziska Hummel, Michael Hummel, Brigitte Wollert-Wulf, Simone Lusatis, Ioannis Anagnostopoulos, Andreas Lietz, Mikael Sigvardsson, Franziska Jundt, Korinna Jöhrens, Kurt Bommert, Harald Stein, Bernd Dörken

ABSTRACT

B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype. More... »

PAGES

207-215

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1285

DOI

http://dx.doi.org/10.1038/ni1285

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030452797

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16369535


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