Interactions of NF-κB with chromatin: the art of being at the right place at the right time View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-05

AUTHORS

Gioacchino Natoli, Simona Saccani, Daniela Bosisio, Ivan Marazzi

ABSTRACT

Transcription factors of the NF-kappaB family are essential regulators of the inflammatory and immune responses. The main 'switch' in NF-kappaB activation is cytoplasmic and leads to the release of NF-kappaB proteins from IkappaB molecules, specific inhibitors that prevent their nuclear accumulation. However, it is becoming increasingly apparent that in addition to this required activation step, both recruitment of NF-kappaB to target genes and NF-kappaB-induced transcriptional events after recruitment are actively controlled. Regulated recruitment of NF-kappaB to chromatin generates kinetic complexity in NF-kappaB-dependent gene induction and 'wires' NF-kappaB-regulated gene activity to simultaneously activated pathways and transcription factors. More... »

PAGES

439-445

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1196

DOI

http://dx.doi.org/10.1038/ni1196

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039677531

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15843800


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