Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-04

AUTHORS

Shimon Sakaguchi

ABSTRACT

Naturally arising CD25(+)CD4(+) regulatory T cells actively maintain immunological self-tolerance. Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. A reduction in their number or function can also elicit tumor immunity, whereas their antigen-specific population expansion can establish transplantation tolerance. They are therefore a good target for designing ways to induce or abrogate immunological tolerance to self and non-self antigens. More... »

PAGES

345-352

References to SciGraph publications

Journal

TITLE

Nature Immunology

ISSUE

4

VOLUME

6

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1178

DOI

http://dx.doi.org/10.1038/ni1178

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034654370

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15785760


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