Dynamic immune responses maintain cytotoxic T lymphocyte epitope mutations in transmitted simian immunodeficiency virus variants View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-03

AUTHORS

Dan H Barouch, Jennifer Powers, Diana M Truitt, Michael G Kishko, Janelle C Arthur, Fred W Peyerl, Marcelo J Kuroda, Darci A Gorgone, Michelle A Lifton, Carol I Lord, Vanessa M Hirsch, David C Montefiori, Angela Carville, Keith G Mansfield, Kevin J Kunstman, Steven M Wolinsky, Norman L Letvin

ABSTRACT

Viral escape from cytotoxic T lymphocytes (CTLs) can undermine immune control of human immunodeficiency virus 1. It is therefore important to assess the stability of viral mutations in CTL epitopes after transmission to naive hosts. Here we demonstrate the persistence of mutations in a dominant CTL epitope after transmission of simian immunodeficiency virus variants to major histocompatibility complex-matched rhesus monkeys. Transient reversions to wild-type sequences occurred and elicited CTLs specific for the wild-type epitope, resulting in immunological pressure that rapidly reselected the mutant viruses. These data suggest that mutations in dominant human immunodeficiency virus 1 CTL epitopes may accumulate in human populations with limited major histocompatibility complex heterogeneity by a mechanism involving dynamic CTL control of transiently reverted wild-type virus. More... »

PAGES

247-252

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1167

DOI

http://dx.doi.org/10.1038/ni1167

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007623494

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15685174


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Download the RDF metadata as:  json-ld nt turtle xml License info

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