Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-10

AUTHORS

Holly Maier, Rachel Ostraat, Hua Gao, Scott Fields, Susan A Shinton, Kay L Medina, Tomokatsu Ikawa, Cornelis Murre, Harinder Singh, Richard R Hardy, James Hagman

ABSTRACT

Cd79a (called mb-1 here) encodes the Ig-alpha signaling component of the B cell receptor. The early B cell-specific mb-1 promoter was hypermethylated at CpG dinucleotides in hematopoietic stem cells but became progressively unmethylated as B cell development proceeded. The transcription factor Pax5 activated endogenous mb-1 transcription in a plasmacytoma cell line, but could not when the promoter was methylated. In this context, early B cell factor (EBF), a transcription factor required for B lymphopoiesis, potentiated activation of mb-1 by Pax5. EBF and the basic helix-loop-helix transcription factor E47 each contributed to epigenetic modifications of the mb-1 promoter, including CpG demethylation and nucleosomal remodeling. EBF function was enhanced by interaction with the transcription factor Runx1. These data suggest a molecular basis for the hierarchical dependence of Pax5 function on EBF and E2A in B lymphocyte development. More... »

PAGES

1069-1077

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1119

DOI

http://dx.doi.org/10.1038/ni1119

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049335763

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15361869


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