Bacterial strategies for overcoming host innate and adaptive immune responses View Full Text


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Article Info

DATE

2002-11-01

AUTHORS

Mathias W. Hornef, Mary Jo Wick, Mikael Rhen, Staffan Normark

ABSTRACT

In higher organisms a variety of host defense mechanisms control the resident microflora and, in most cases, effectively prevent invasive microbial disease. However, it appears that microbial organisms have coevolved with their hosts to overcome protective host barriers and, in selected cases, actually take advantage of innate host responses. Many microbial pathogens avoid host recognition or dampen the subsequent immune activation through sophisticated interactions with host responses, but some pathogens benefit from the stimulation of inflammatory reactions. This review will describe the spectrum of strategies used by microbes to avoid or provoke activation of the host's immune response as well as our current understanding of the role this immunomodulatory interference plays during microbial pathogenesis. More... »

PAGES

1033-1040

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ni1102-1033

    DOI

    http://dx.doi.org/10.1038/ni1102-1033

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038464800

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/12407412


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