Deliberate removal of T cell help improves virus-neutralizing antibody production View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2004-09

AUTHORS

Mike Recher, Karl S Lang, Lukas Hunziker, Stefan Freigang, Bruno Eschli, Nicola L Harris, Alexander Navarini, Beatrice M Senn, Katja Fink, Marius Lötscher, Lars Hangartner, Raphaël Zellweger, Martin Hersberger, Alexandre Theocharides, Hans Hengartner, Rolf M Zinkernagel

ABSTRACT

The B cell response to lymphocytic choriomeningitis virus is characterized by a CD4(+) T cell-dependent polyclonal hypergammaglobulinemia and delayed formation of virus-specific neutralizing antibodies. Here we provide evidence that, paradoxically, because of polyclonal B cell activation, virus-specific T cell help impairs the induction of neutralizing antibody responses. Experimental reduction in CD4(+) T cell help in vivo resulted in potent neutralizing antibody responses without impairment of CD8(+) T cell activity. These unexpected consequences of polyclonal B cell activation may affect vaccine strategies and the treatment of clinically relevant chronic bacterial, parasitic and viral infections in which hypergammaglobulinemia is regularly found. More... »

PAGES

934-942

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1102

DOI

http://dx.doi.org/10.1038/ni1102

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044078138

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15300247


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