Protein kinase C and beyond View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-08

AUTHORS

Martin Spitaler, Doreen A Cantrell

ABSTRACT

Protein kinase C molecules regulate both positive and negative signal transduction pathways essential for the initiation and homeostasis of immune responses. There are multiple isoforms of protein kinase C that are activated differently by calcium and diacylglycerol, and these are activated mainly by antigen receptors in T cells, B cells and mast cells. Additionally, mammals express several other diacylglycerol binding proteins that are linked to a network of key signal transduction pathways that control lymphocyte biology. Diacylglycerol and protein kinase C regulate a broad range of gene transcription programs but also modulate integrins, chemokine responses and antigen receptors, thereby regulating lymphocyte adhesion, migration, differentiation and proliferation. More... »

PAGES

785-790

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1097

DOI

http://dx.doi.org/10.1038/ni1097

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053440000

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15282562


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