53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05

AUTHORS

John P Manis, Julio C Morales, Zhenfang Xia, Jeffery L Kutok, Frederick W Alt, Phillip B Carpenter

ABSTRACT

The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hypermutation (SHM), the processes by which immunoglobulin (Ig) variable region exons are assembled and mutated, it was required for Igh class-switch recombination (CSR), the recombination and deletion process by which Igh constant region genes are exchanged. When stimulated to undergo CSR, 53BP1-deficient cells exhibited no defect in C(H) germline transcription or AID expression, however these cells had a profound decrease in switch junctions. The current findings, in combination with the known 53BP1 functions and how it is activated, implicate the DNA damage response to DSBs in the joining phase of class-switch recombination. More... »

PAGES

481-487

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ni1067

DOI

http://dx.doi.org/10.1038/ni1067

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029417068

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15077110


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Class Switching", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Constant Regions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intracellular Signaling Peptides and Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoproteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Howard Hughes Medical Institute, The Children's Hospital; The Department of Genetics, Harvard Medical School; and The CBR Institute for Biomedical Research; Boston, Massachusetts, 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manis", 
        "givenName": "John P", 
        "id": "sg:person.0601361550.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601361550.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at Houston", 
          "id": "https://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morales", 
        "givenName": "Julio C", 
        "id": "sg:person.0642677273.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642677273.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at Houston", 
          "id": "https://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xia", 
        "givenName": "Zhenfang", 
        "id": "sg:person.01132267204.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132267204.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "The Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kutok", 
        "givenName": "Jeffery L", 
        "id": "sg:person.016364037777.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016364037777.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Howard Hughes Medical Institute, The Children's Hospital; The Department of Genetics, Harvard Medical School; and The CBR Institute for Biomedical Research; Boston, Massachusetts, 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alt", 
        "givenName": "Frederick W", 
        "id": "sg:person.014743374617.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014743374617.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at Houston", 
          "id": "https://www.grid.ac/institutes/grid.267308.8", 
          "name": [
            "Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Carpenter", 
        "givenName": "Phillip B", 
        "id": "sg:person.01111123172.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111123172.57"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1128/mcb.8.4.1849", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001426620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.151.7.1381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002675122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/414660a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002710847", 
          "https://doi.org/10.1038/414660a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/414660a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002710847", 
          "https://doi.org/10.1038/414660a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.19.2411", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003425282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005730946", 
          "https://doi.org/10.1038/ni920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni920", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005730946", 
          "https://doi.org/10.1038/ni920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00706-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006514172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006561770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m212484200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008903063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.3.951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012618716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/25.10.1913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012806956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/23.5.687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013536789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0730835100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017097999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1069398", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017161096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00675-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017581492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00079-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017640960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.12.3484", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018343030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20001871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019610069"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-065x.2003.00060.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026158810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.178.4.1381", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026425912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00078-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027678949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35056049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028620907", 
          "https://doi.org/10.1038/35056049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35056049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028620907", 
          "https://doi.org/10.1038/35056049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029003147", 
          "https://doi.org/10.1038/ncb892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029003147", 
          "https://doi.org/10.1038/ncb892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60866-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030594668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1161904", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032689053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(02)00306-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033862053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2003.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033864801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2003.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033864801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m007665200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034021460"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.23.7.2556-2563.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037081419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m304066200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037118034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.184.1.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038685213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0703-631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039020923", 
          "https://doi.org/10.1038/ni0703-631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni0703-631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039020923", 
          "https://doi.org/10.1038/ni0703-631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.153.3.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039282163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039624151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039958608", 
          "https://doi.org/10.1038/ncb884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncb884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039958608", 
          "https://doi.org/10.1038/ncb884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.10.5858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040536653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.21.5.1719-1729.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041504593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042422670", 
          "https://doi.org/10.1038/nature01574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature01574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042422670", 
          "https://doi.org/10.1038/nature01574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20020380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044810928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(04)00039-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047167528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.122228699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048193879"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4906(01)02111-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049382317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(03)00111-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051393855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0968-0004(03)00111-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051393855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.914401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051908786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051995209", 
          "https://doi.org/10.1038/ni1036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051995209", 
          "https://doi.org/10.1038/ni1036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)01247-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052692643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(02)01247-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052692643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35044005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053296306", 
          "https://doi.org/10.1038/35044005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35044005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053296306", 
          "https://doi.org/10.1038/35044005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1076182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.3.2.684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072297840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.12.6556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076609553"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-05", 
    "datePublishedReg": "2004-05-01", 
    "description": "The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hypermutation (SHM), the processes by which immunoglobulin (Ig) variable region exons are assembled and mutated, it was required for Igh class-switch recombination (CSR), the recombination and deletion process by which Igh constant region genes are exchanged. When stimulated to undergo CSR, 53BP1-deficient cells exhibited no defect in C(H) germline transcription or AID expression, however these cells had a profound decrease in switch junctions. The current findings, in combination with the known 53BP1 functions and how it is activated, implicate the DNA damage response to DSBs in the joining phase of class-switch recombination.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ni1067", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2435766", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1022778", 
        "issn": [
          "1529-2908", 
          "1529-2916"
        ], 
        "name": "Nature Immunology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination", 
    "pagination": "481-487", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "8c235c00d5554da640f7e48f5d81b1232fb92a600477e2d33c33833340fb84b4"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15077110"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100941354"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ni1067"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1029417068"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ni1067", 
      "https://app.dimensions.ai/details/publication/pub.1029417068"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87091_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/ni1067"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ni1067'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ni1067'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ni1067'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ni1067'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      21 PREDICATES      89 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ni1067 schema:about N25fa35c331454eff8f5b64e90f41a264
2 N32c63ce034b640ffa4689149dc302c81
3 N3990f75868be4e3ca4714d4e82513d3e
4 N49974e5efa494161a2b4bab46236a2cb
5 N4d378af0404541fcb5680e2b232fd59a
6 N583b69cfe3b94168b54e47c23e6461ea
7 N82d6d531a8d94671b75cf61e5d32886a
8 N8c497d175772426c9aae8bc3e207cc43
9 N908f6c92f7f74bc9960e431a83bc45a2
10 Nb8e6068fcf1b40d998ae91b0cecd357b
11 Nfeeffa0b43ef4c21bb7cf2e241367abd
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Nc7c23d5033e44894ba02985fc667cbd3
15 schema:citation sg:pub.10.1038/35044005
16 sg:pub.10.1038/35056049
17 sg:pub.10.1038/414660a
18 sg:pub.10.1038/nature01574
19 sg:pub.10.1038/ncb884
20 sg:pub.10.1038/ncb892
21 sg:pub.10.1038/ni0703-631
22 sg:pub.10.1038/ni1036
23 sg:pub.10.1038/ni920
24 https://doi.org/10.1016/j.dnarep.2003.08.010
25 https://doi.org/10.1016/s0065-2776(08)60866-4
26 https://doi.org/10.1016/s0092-8674(00)00078-7
27 https://doi.org/10.1016/s0092-8674(00)00079-9
28 https://doi.org/10.1016/s0092-8674(02)00675-x
29 https://doi.org/10.1016/s0092-8674(02)00706-7
30 https://doi.org/10.1016/s0092-8674(04)00039-x
31 https://doi.org/10.1016/s0960-9822(02)01247-2
32 https://doi.org/10.1016/s0968-0004(03)00111-7
33 https://doi.org/10.1016/s1074-7613(02)00306-0
34 https://doi.org/10.1016/s1471-4906(01)02111-1
35 https://doi.org/10.1034/j.1600-065x.2003.00060.x
36 https://doi.org/10.1073/pnas.0730835100
37 https://doi.org/10.1073/pnas.122228699
38 https://doi.org/10.1074/jbc.273.10.5858
39 https://doi.org/10.1074/jbc.m007665200
40 https://doi.org/10.1074/jbc.m212484200
41 https://doi.org/10.1074/jbc.m304066200
42 https://doi.org/10.1083/jcb.151.7.1381
43 https://doi.org/10.1083/jcb.153.3.613
44 https://doi.org/10.1084/jem.178.3.951
45 https://doi.org/10.1084/jem.178.4.1381
46 https://doi.org/10.1084/jem.184.1.277
47 https://doi.org/10.1084/jem.20001871
48 https://doi.org/10.1084/jem.20020380
49 https://doi.org/10.1084/jem.20030481
50 https://doi.org/10.1084/jem.20030569
51 https://doi.org/10.1093/carcin/23.5.687
52 https://doi.org/10.1093/emboj/18.12.3484
53 https://doi.org/10.1093/nar/25.10.1913
54 https://doi.org/10.1101/gad.10.19.2411
55 https://doi.org/10.1101/gad.1161904
56 https://doi.org/10.1101/gad.914401
57 https://doi.org/10.1126/science.1069398
58 https://doi.org/10.1126/science.1076182
59 https://doi.org/10.1128/mcb.21.5.1719-1729.2001
60 https://doi.org/10.1128/mcb.23.7.2556-2563.2003
61 https://doi.org/10.1128/mcb.8.4.1849
62 https://doi.org/10.4049/jimmunol.171.12.6556
63 https://doi.org/10.4161/cc.3.2.684
64 schema:datePublished 2004-05
65 schema:datePublishedReg 2004-05-01
66 schema:description The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hypermutation (SHM), the processes by which immunoglobulin (Ig) variable region exons are assembled and mutated, it was required for Igh class-switch recombination (CSR), the recombination and deletion process by which Igh constant region genes are exchanged. When stimulated to undergo CSR, 53BP1-deficient cells exhibited no defect in C(H) germline transcription or AID expression, however these cells had a profound decrease in switch junctions. The current findings, in combination with the known 53BP1 functions and how it is activated, implicate the DNA damage response to DSBs in the joining phase of class-switch recombination.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree false
70 schema:isPartOf N4af6cf24f54d4815a6513b791358ebd4
71 N60ce18263ed8471d82b6bdc30ad53062
72 sg:journal.1022778
73 schema:name 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination
74 schema:pagination 481-487
75 schema:productId N5b2db2a8d25f415297b76dafb4ec6c35
76 N8aca11d07b6745309c4896afe4a76541
77 Nb5ac0f4d69ff4c06a871db1d07f2bc80
78 Nd3f422874edc4aeb8b5ca02d3e801e8e
79 Nddd5a7e0e1e8477f837c7c04c1d29e5d
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029417068
81 https://doi.org/10.1038/ni1067
82 schema:sdDatePublished 2019-04-11T12:23
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N9e969dac360142caa466ab6f571e6424
85 schema:url http://www.nature.com/articles/ni1067
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N14b1439b864b4203968caace1589b993 rdf:first sg:person.014743374617.58
90 rdf:rest N3430c0c4dafc4ae7b8bcd3e31c51ca07
91 N25fa35c331454eff8f5b64e90f41a264 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name DNA Damage
93 rdf:type schema:DefinedTerm
94 N32c63ce034b640ffa4689149dc302c81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Intracellular Signaling Peptides and Proteins
96 rdf:type schema:DefinedTerm
97 N3430c0c4dafc4ae7b8bcd3e31c51ca07 rdf:first sg:person.01111123172.57
98 rdf:rest rdf:nil
99 N3990f75868be4e3ca4714d4e82513d3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N4389b41e49824cb98bcf04b671623715 schema:name Howard Hughes Medical Institute, The Children's Hospital; The Department of Genetics, Harvard Medical School; and The CBR Institute for Biomedical Research; Boston, Massachusetts, 02115, USA.
103 rdf:type schema:Organization
104 N45c1c56b9c0344918c1f48e319721c8f rdf:first sg:person.016364037777.97
105 rdf:rest N14b1439b864b4203968caace1589b993
106 N49974e5efa494161a2b4bab46236a2cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name DNA Repair
108 rdf:type schema:DefinedTerm
109 N4af6cf24f54d4815a6513b791358ebd4 schema:issueNumber 5
110 rdf:type schema:PublicationIssue
111 N4d378af0404541fcb5680e2b232fd59a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Mice
113 rdf:type schema:DefinedTerm
114 N583b69cfe3b94168b54e47c23e6461ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Carrier Proteins
116 rdf:type schema:DefinedTerm
117 N5b2db2a8d25f415297b76dafb4ec6c35 schema:name dimensions_id
118 schema:value pub.1029417068
119 rdf:type schema:PropertyValue
120 N60ce18263ed8471d82b6bdc30ad53062 schema:volumeNumber 5
121 rdf:type schema:PublicationVolume
122 N6684ca39515d488db8d6bc0269872d2b rdf:first sg:person.0642677273.03
123 rdf:rest Na4d069d15e294a8fa5b6346fd8ed3103
124 N82d6d531a8d94671b75cf61e5d32886a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name B-Lymphocytes
126 rdf:type schema:DefinedTerm
127 N836c5931ed2046859b9783e5e2dfb63c schema:name Howard Hughes Medical Institute, The Children's Hospital; The Department of Genetics, Harvard Medical School; and The CBR Institute for Biomedical Research; Boston, Massachusetts, 02115, USA.
128 rdf:type schema:Organization
129 N8aca11d07b6745309c4896afe4a76541 schema:name readcube_id
130 schema:value 8c235c00d5554da640f7e48f5d81b1232fb92a600477e2d33c33833340fb84b4
131 rdf:type schema:PropertyValue
132 N8c497d175772426c9aae8bc3e207cc43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Mice, Knockout
134 rdf:type schema:DefinedTerm
135 N908f6c92f7f74bc9960e431a83bc45a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Immunoglobulin Class Switching
137 rdf:type schema:DefinedTerm
138 N9e969dac360142caa466ab6f571e6424 schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Na4d069d15e294a8fa5b6346fd8ed3103 rdf:first sg:person.01132267204.00
141 rdf:rest N45c1c56b9c0344918c1f48e319721c8f
142 Nb5ac0f4d69ff4c06a871db1d07f2bc80 schema:name pubmed_id
143 schema:value 15077110
144 rdf:type schema:PropertyValue
145 Nb8e6068fcf1b40d998ae91b0cecd357b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Phosphoproteins
147 rdf:type schema:DefinedTerm
148 Nc7c23d5033e44894ba02985fc667cbd3 rdf:first sg:person.0601361550.55
149 rdf:rest N6684ca39515d488db8d6bc0269872d2b
150 Nd3f422874edc4aeb8b5ca02d3e801e8e schema:name doi
151 schema:value 10.1038/ni1067
152 rdf:type schema:PropertyValue
153 Nddd5a7e0e1e8477f837c7c04c1d29e5d schema:name nlm_unique_id
154 schema:value 100941354
155 rdf:type schema:PropertyValue
156 Nfeeffa0b43ef4c21bb7cf2e241367abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Immunoglobulin Constant Regions
158 rdf:type schema:DefinedTerm
159 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
160 schema:name Biological Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
163 schema:name Genetics
164 rdf:type schema:DefinedTerm
165 sg:grant.2435766 http://pending.schema.org/fundedItem sg:pub.10.1038/ni1067
166 rdf:type schema:MonetaryGrant
167 sg:journal.1022778 schema:issn 1529-2908
168 1529-2916
169 schema:name Nature Immunology
170 rdf:type schema:Periodical
171 sg:person.01111123172.57 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
172 schema:familyName Carpenter
173 schema:givenName Phillip B
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111123172.57
175 rdf:type schema:Person
176 sg:person.01132267204.00 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
177 schema:familyName Xia
178 schema:givenName Zhenfang
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132267204.00
180 rdf:type schema:Person
181 sg:person.014743374617.58 schema:affiliation N4389b41e49824cb98bcf04b671623715
182 schema:familyName Alt
183 schema:givenName Frederick W
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014743374617.58
185 rdf:type schema:Person
186 sg:person.016364037777.97 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
187 schema:familyName Kutok
188 schema:givenName Jeffery L
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016364037777.97
190 rdf:type schema:Person
191 sg:person.0601361550.55 schema:affiliation N836c5931ed2046859b9783e5e2dfb63c
192 schema:familyName Manis
193 schema:givenName John P
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601361550.55
195 rdf:type schema:Person
196 sg:person.0642677273.03 schema:affiliation https://www.grid.ac/institutes/grid.267308.8
197 schema:familyName Morales
198 schema:givenName Julio C
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642677273.03
200 rdf:type schema:Person
201 sg:pub.10.1038/35044005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053296306
202 https://doi.org/10.1038/35044005
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/35056049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028620907
205 https://doi.org/10.1038/35056049
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/414660a schema:sameAs https://app.dimensions.ai/details/publication/pub.1002710847
208 https://doi.org/10.1038/414660a
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/nature01574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042422670
211 https://doi.org/10.1038/nature01574
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/ncb884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039958608
214 https://doi.org/10.1038/ncb884
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/ncb892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029003147
217 https://doi.org/10.1038/ncb892
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ni0703-631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039020923
220 https://doi.org/10.1038/ni0703-631
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/ni1036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051995209
223 https://doi.org/10.1038/ni1036
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ni920 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005730946
226 https://doi.org/10.1038/ni920
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.dnarep.2003.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033864801
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/s0065-2776(08)60866-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030594668
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0092-8674(00)00078-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027678949
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0092-8674(00)00079-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017640960
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0092-8674(02)00675-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017581492
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0092-8674(02)00706-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006514172
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0092-8674(04)00039-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1047167528
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0960-9822(02)01247-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052692643
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0968-0004(03)00111-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051393855
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/s1074-7613(02)00306-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033862053
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/s1471-4906(01)02111-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049382317
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1034/j.1600-065x.2003.00060.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026158810
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1073/pnas.0730835100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017097999
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.122228699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048193879
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1074/jbc.273.10.5858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040536653
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1074/jbc.m007665200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034021460
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1074/jbc.m212484200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008903063
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1074/jbc.m304066200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037118034
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1083/jcb.151.7.1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002675122
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1083/jcb.153.3.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039282163
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1084/jem.178.3.951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012618716
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1084/jem.178.4.1381 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026425912
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1084/jem.184.1.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038685213
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1084/jem.20001871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019610069
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1084/jem.20020380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044810928
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1084/jem.20030481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039624151
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1084/jem.20030569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006561770
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1093/carcin/23.5.687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013536789
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1093/emboj/18.12.3484 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018343030
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1093/nar/25.10.1913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012806956
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1101/gad.10.19.2411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003425282
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1101/gad.1161904 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032689053
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1101/gad.914401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051908786
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.1069398 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017161096
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1126/science.1076182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446938
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1128/mcb.21.5.1719-1729.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041504593
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1128/mcb.23.7.2556-2563.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037081419
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1128/mcb.8.4.1849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001426620
303 rdf:type schema:CreativeWork
304 https://doi.org/10.4049/jimmunol.171.12.6556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076609553
305 rdf:type schema:CreativeWork
306 https://doi.org/10.4161/cc.3.2.684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072297840
307 rdf:type schema:CreativeWork
308 https://www.grid.ac/institutes/grid.267308.8 schema:alternateName The University of Texas Health Science Center at Houston
309 schema:name Department of Biochemistry and Molecular Biology, University of Texas Health Science Center, Houston, Texas 77030, USA.
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
312 schema:name The Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA.
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...